Q9XLW8 (COX2_LACK1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COX2

Encoded on

Mitochondrion

Organism

Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) (Yeast) (Saccharomyces kluyveri)

Taxonomic identifier

226302 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Lachancea › Lachancea kluyveri

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Post-translational modification	The signal sequence of COX2 is processed by IMP1 By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	By similarity
	Chain	16 – 251	236	Cytochrome c oxidase subunit 2		PRO_0000006042
Regions
	Topological domain	16 – 42	27	Mitochondrial intermembrane Potential
	Transmembrane	43 – 64	22	Helical; Potential
	Topological domain	65 – 82	18	Mitochondrial matrix Potential
	Transmembrane	83 – 107	25	Helical; Potential
	Topological domain	108 – 251	144	Mitochondrial intermembrane Potential
Sites
	Metal binding	186	1	Copper A By similarity
	Metal binding	221	1	Copper A By similarity
	Metal binding	225	1	Copper A By similarity
	Metal binding	229	1	Copper A By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9XLW8 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: AF944785291AA7F0	FASTA	251	28,410
	10 20 30 40 50 60 MLTFLSNLNN MIIMNDVPTP YGVYFQDSAT PNQEGILELH DNIMFYLLVI LGLVSWLLFT 70 80 90 100 110 120 ITRTYSKNPI AYKYIKHGQT IEIIWTIFPA VVLLIIAFPS FILLYLCDEV ISPAMTIKAI 130 140 150 160 170 180 GLQWYWKYEY SDFINESGET VEFESYVIPE DLLEDGQLRL LDTDTSVVVP VDTHIRFVVT 190 200 210 220 230 240 AADVIHDFAI PSLGIKVDAT PGRLNQVSAL IQREGVFYGQ CSELCGTAHS AMPIKIEAVS 250 LPSFLEWLNE Q

References

[1]

"Highly diverged homologs of Saccharomyces cerevisiae mitochondrial mRNA-specific translational activators have orthologous functions in other budding yeasts." Costanzo M.C., Bonnefoy N., Williams E.H., Clark-Walker G.D., Fox T.D. Genetics 154:999-1012(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF120715 Genomic DNA. Translation: AAD29122.1.
RefSeq	YP_006460459.1. NC_018056.1.
3D structure databases
ProteinModelPortal	Q9XLW8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	13083818.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_LACK1

Accession

Primary (citable) accession number: Q9XLW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program