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Q9XLW8 (COX2_LACK1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismLachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) (Yeast) (Saccharomyces kluyveri)
Taxonomic identifier226302 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Post-translational modification

The signal sequence of COX2 is processed by IMP1 By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 By similarity
Chain16 – 251236Cytochrome c oxidase subunit 2
PRO_0000006042

Regions

Topological domain16 – 4227Mitochondrial intermembrane Potential
Transmembrane43 – 6422Helical; Potential
Topological domain65 – 8218Mitochondrial matrix Potential
Transmembrane83 – 10725Helical; Potential
Topological domain108 – 251144Mitochondrial intermembrane Potential

Sites

Metal binding1861Copper A By similarity
Metal binding2211Copper A By similarity
Metal binding2251Copper A By similarity
Metal binding2291Copper A By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XLW8 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: AF944785291AA7F0

FASTA25128,410
        10         20         30         40         50         60 
MLTFLSNLNN MIIMNDVPTP YGVYFQDSAT PNQEGILELH DNIMFYLLVI LGLVSWLLFT 

        70         80         90        100        110        120 
ITRTYSKNPI AYKYIKHGQT IEIIWTIFPA VVLLIIAFPS FILLYLCDEV ISPAMTIKAI 

       130        140        150        160        170        180 
GLQWYWKYEY SDFINESGET VEFESYVIPE DLLEDGQLRL LDTDTSVVVP VDTHIRFVVT 

       190        200        210        220        230        240 
AADVIHDFAI PSLGIKVDAT PGRLNQVSAL IQREGVFYGQ CSELCGTAHS AMPIKIEAVS 

       250 
LPSFLEWLNE Q 

« Hide

References

[1]"Highly diverged homologs of Saccharomyces cerevisiae mitochondrial mRNA-specific translational activators have orthologous functions in other budding yeasts."
Costanzo M.C., Bonnefoy N., Williams E.H., Clark-Walker G.D., Fox T.D.
Genetics 154:999-1012(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF120715 Genomic DNA. Translation: AAD29122.1.
RefSeqYP_006460459.1. NC_018056.1.

3D structure databases

ProteinModelPortalQ9XLW8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID13083818.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_LACK1
AccessionPrimary (citable) accession number: Q9XLW8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families