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Q9XJ58 (CHS1_CITSI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 1

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 1
Gene names
Name:CHS1
OrganismCitrus sinensis (Sweet orange) (Citrus aurantium var. sinensis)
Taxonomic identifier2711 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeCitrus

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Chalcone synthase 1
PRO_0000215968

Sites

Active site1631 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XJ58 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 4A066BAA5F28DE8F

FASTA38942,547
        10         20         30         40         50         60 
MVTVDEVRKA QRAQGPATIM AIGTATPPNC VDQSTYPDYY FRITNSEHMT DLKEKFKRMC 

        70         80         90        100        110        120 
DKSMIKKRYM YLTEEILKEN PNVCAYMAPS LDTRQDMVVV EVPRLGKAAT EAIKEWGQPK 

       130        140        150        160        170        180 
SKITHLVFCT TSGVDMPGAD YRLTKLLGLR PSVKRLMMYQ QGCFAGGTVL RLAKDLAENN 

       190        200        210        220        230        240 
KGARVLVVCS EITAVTFRGP SDTHLDSLVG QALFGDGAAA IIIGADPIPE IEKPMFELVS 

       250        260        270        280        290        300 
TAQTILPDSD GSIDGHLREA GLTFHLLKDV PGLISKNIQK SLTEAFKPLG ISDWNSIFWI 

       310        320        330        340        350        360 
AHPGGPAILD QVEEKLGLKP EKLRATRHVL SEYGNMSSAC VLFILDEMRK KSAEDGLETA 

       370        380 
GEGLEWGVLF GFGPGLTVET VVLHSVAAA 

« Hide

References

[1]"One type of chalcone synthase gene expressed during embryogenesis regulates the flavonoid accumulation in citrus cell cultures."
Moriguchi T., Kita M., Tomono Y., Endo-Inagaki T., Omura M.
Plant Cell Physiol. 40:651-655(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009350 mRNA. Translation: BAA81663.1.

3D structure databases

ProteinModelPortalQ9XJ58.
SMRQ9XJ58. Positions 3-387.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS1_CITSI
AccessionPrimary (citable) accession number: Q9XJ58
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways