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Q9XJ58

- CHS1_CITSI

UniProt

Q9XJ58 - CHS1_CITSI

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Protein
Chalcone synthase 1
Gene
CHS1
Organism
Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei163 – 1631 By similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1
Gene namesi
Name:CHS1
OrganismiCitrus sinensis (Sweet orange) (Citrus aurantium var. sinensis)
Taxonomic identifieri2711 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeCitrus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Chalcone synthase 1
PRO_0000215968Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9XJ58.
SMRiQ9XJ58. Positions 3-387.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XJ58-1 [UniParc]FASTAAdd to Basket

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MVTVDEVRKA QRAQGPATIM AIGTATPPNC VDQSTYPDYY FRITNSEHMT    50
DLKEKFKRMC DKSMIKKRYM YLTEEILKEN PNVCAYMAPS LDTRQDMVVV 100
EVPRLGKAAT EAIKEWGQPK SKITHLVFCT TSGVDMPGAD YRLTKLLGLR 150
PSVKRLMMYQ QGCFAGGTVL RLAKDLAENN KGARVLVVCS EITAVTFRGP 200
SDTHLDSLVG QALFGDGAAA IIIGADPIPE IEKPMFELVS TAQTILPDSD 250
GSIDGHLREA GLTFHLLKDV PGLISKNIQK SLTEAFKPLG ISDWNSIFWI 300
AHPGGPAILD QVEEKLGLKP EKLRATRHVL SEYGNMSSAC VLFILDEMRK 350
KSAEDGLETA GEGLEWGVLF GFGPGLTVET VVLHSVAAA 389
Length:389
Mass (Da):42,547
Last modified:November 1, 1999 - v1
Checksum:i4A066BAA5F28DE8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009350 mRNA. Translation: BAA81663.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009350 mRNA. Translation: BAA81663.1 .

3D structure databases

ProteinModelPortali Q9XJ58.
SMRi Q9XJ58. Positions 3-387.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "One type of chalcone synthase gene expressed during embryogenesis regulates the flavonoid accumulation in citrus cell cultures."
    Moriguchi T., Kita M., Tomono Y., Endo-Inagaki T., Omura M.
    Plant Cell Physiol. 40:651-655(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCHS1_CITSI
AccessioniPrimary (citable) accession number: Q9XJ58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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