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Q9XJ57 (CHS2_CITSI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 2

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 2
Gene names
Name:CHS2
OrganismCitrus sinensis (Sweet orange) (Citrus aurantium var. sinensis)
Taxonomic identifier2711 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeCitrus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Chalcone synthase 2
PRO_0000215969

Sites

Active site1641 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XJ57 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: F59029AC36890C54

FASTA39142,592
        10         20         30         40         50         60 
MATVQEIRNA QRADGPATVL AIGTATPAHS VNQADYPDYY FRITKSEHMT ELKEKFKRMC 

        70         80         90        100        110        120 
DKSMIKKRYM YLTEEILKEN PNMCAYMAPS LDARQDIVVV EVPKLGKEAA TKAIKEWGQP 

       130        140        150        160        170        180 
KSKITHLIFC TTSGVDMPGA DYQLTKLIGL RPSVKRFMMY QQGCFAGGTV LRLAKDLAEN 

       190        200        210        220        230        240 
NKGARVLVVC SEITAVTFRG PADTHLDSLV GQALFGDGAA AVIVGADPDT SVERPLYQLV 

       250        260        270        280        290        300 
STSQTILPDS DGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLSEAFAPL GISDWNSIFW 

       310        320        330        340        350        360 
IAHPGGPAIL DQVESKLGLK GEKLKATRQV LSEYGNMSSA CVLFILDEMR KKSVEEAKAT 

       370        380        390 
TGEGLDWGVL FGFGPGLTVE TVVLHSVPIK A 

« Hide

References

[1]"One type of chalcone synthase gene expressed during embryogenesis regulates the flavonoid accumulation in citrus cell cultures."
Moriguchi T., Kita M., Tomono Y., Endo-Inagaki T., Omura M.
Plant Cell Physiol. 40:651-655(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009351 mRNA. Translation: BAA81664.1.

3D structure databases

ProteinModelPortalQ9XJ57.
SMRQ9XJ57. Positions 3-389.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9XJ57.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS2_CITSI
AccessionPrimary (citable) accession number: Q9XJ57
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways