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Protein

GPCR-type G protein 1

Gene

GTG1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Abscisic acid receptor. The GDP-bound form exhibits greater abscisic acid binding than the GTP-bound form (PubMed:19135895). Required for seedling growth and fertility (PubMed:23001037).2 Publications

Enzyme regulationi

The GTPase activity is Mg2+ dependent and is strongly inhibited by the interaction with GPA1.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi382 – 411GTPCuratedAdd BLAST30

GO - Molecular functioni

  • abscisic acid binding Source: TAIR
  • GTPase binding Source: TAIR
  • GTP binding Source: TAIR

GO - Biological processi

  • post-embryonic development Source: TAIR
  • response to abscisic acid Source: TAIR
  • vegetative to reproductive phase transition of meristem Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GPCR-type G protein 1
Gene namesi
Name:GTG1
Ordered Locus Names:At1g64990
ORF Names:F13O11.29
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G64990.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei297 – 319HelicalSequence analysisAdd BLAST23
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: TAIR
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype; due to the redundancy with GTG2. The double mutants gtg1 and gtg2 are hyposensitive to abscisic acid.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003670581 – 468GPCR-type G protein 1Add BLAST468

Proteomic databases

PaxDbiQ9XIP7.

Expressioni

Tissue specificityi

Expressed in cotyledons, leaves, stems, roots, flowers and guard cells.1 Publication

Inductioni

Not induced by abscisic acid, cold, salt or drought treatments.1 Publication

Gene expression databases

GenevisibleiQ9XIP7. AT.

Interactioni

Subunit structurei

Interacts with GPA1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GPA1P180642EBI-2214605,EBI-443890

GO - Molecular functioni

  • GTPase binding Source: TAIR

Protein-protein interaction databases

BioGridi28028. 1 interactor.
IntActiQ9XIP7. 1 interactor.
STRINGi3702.AT1G64990.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XIP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili243 – 279Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi206 – 209Poly-Lys4

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2417. Eukaryota.
ENOG410XQ8R. LUCA.
HOGENOMiHOG000240999.
InParanoidiQ9XIP7.
OMAiLIAYSCI.
OrthoDBiEOG09360BG8.
PhylomeDBiQ9XIP7.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR/GTG.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. GPHR_N. 1 hit.
[Graphical view]
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XIP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYGWAIYEG TVVIASLSLL GWAGLWFLNR RLYKEYEEKR ALVQIIFSVV
60 70 80 90 100
FAFSCNLLQL VLFEIIPVLS REARMINWKV DLFCLILLLV FMLPYYHCYL
110 120 130 140 150
MLRNSGVRRE RASVGAFLFL SAFLYAFWRM GVHFPMPSAD KGFFTMPQLV
160 170 180 190 200
SRIGVIGVTL MAVLSGFGAV NLPYSYISLF IREIEEADII SLERQLIQST
210 220 230 240 250
ETCIAKKKKI ILCQLEVERN QGSEENQKRS SFFRRIVGTV VRSVQDDQKE
260 270 280 290 300
QDIKILEAEV EALEELSKQL FLEVYELRQA KDAAAYSRTW KGHVQNLLGY
310 320 330 340 350
ACSIYCVYKM LKSLQSVVFK EAGTKDPVTT MISIFLRLFD IGVDAALLSQ
360 370 380 390 400
YISLLFIGML IVISVRGFLT NLMKFFFAVS RVGSGSSSNV VLFLSEIMGM
410 420 430 440 450
YFLSSILLIR KSLRNEYRGI ITDVLGGDIQ FDFYHRWFDA IFVASAFLSL
460
VLLSAHYTSR QSDKHAIE
Length:468
Mass (Da):53,546
Last modified:November 1, 1999 - v1
Checksum:iB267D260A6E4BF8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM776216 mRNA. Translation: AEF15911.1.
AC006193 Genomic DNA. Translation: AAD38272.1.
CP002684 Genomic DNA. Translation: AEE34312.1.
CP002684 Genomic DNA. Translation: AEE34313.1.
AY070446 mRNA. Translation: AAL49849.1.
PIRiE96673.
RefSeqiNP_001031235.1. NM_001036158.2.
NP_176679.2. NM_105173.4.
UniGeneiAt.28354.

Genome annotation databases

EnsemblPlantsiAT1G64990.1; AT1G64990.1; AT1G64990.
AT1G64990.2; AT1G64990.2; AT1G64990.
GeneIDi842807.
GrameneiAT1G64990.1; AT1G64990.1; AT1G64990.
AT1G64990.2; AT1G64990.2; AT1G64990.
KEGGiath:AT1G64990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM776216 mRNA. Translation: AEF15911.1.
AC006193 Genomic DNA. Translation: AAD38272.1.
CP002684 Genomic DNA. Translation: AEE34312.1.
CP002684 Genomic DNA. Translation: AEE34313.1.
AY070446 mRNA. Translation: AAL49849.1.
PIRiE96673.
RefSeqiNP_001031235.1. NM_001036158.2.
NP_176679.2. NM_105173.4.
UniGeneiAt.28354.

3D structure databases

ProteinModelPortaliQ9XIP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28028. 1 interactor.
IntActiQ9XIP7. 1 interactor.
STRINGi3702.AT1G64990.1.

Proteomic databases

PaxDbiQ9XIP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G64990.1; AT1G64990.1; AT1G64990.
AT1G64990.2; AT1G64990.2; AT1G64990.
GeneIDi842807.
GrameneiAT1G64990.1; AT1G64990.1; AT1G64990.
AT1G64990.2; AT1G64990.2; AT1G64990.
KEGGiath:AT1G64990.

Organism-specific databases

TAIRiAT1G64990.

Phylogenomic databases

eggNOGiKOG2417. Eukaryota.
ENOG410XQ8R. LUCA.
HOGENOMiHOG000240999.
InParanoidiQ9XIP7.
OMAiLIAYSCI.
OrthoDBiEOG09360BG8.
PhylomeDBiQ9XIP7.

Miscellaneous databases

PROiQ9XIP7.

Gene expression databases

GenevisibleiQ9XIP7. AT.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR/GTG.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. GPHR_N. 1 hit.
[Graphical view]
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTG1_ARATH
AccessioniPrimary (citable) accession number: Q9XIP7
Secondary accession number(s): G0WVT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Has both a topology similar to GPCRs and a GTP-binding/GTPase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.