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Q9XIP7

- GTG1_ARATH

UniProt

Q9XIP7 - GTG1_ARATH

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Protein
GPCR-type G protein 1
Gene
GTG1, At1g64990, F13O11.29
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Abscisic acid receptor. The GDP-bound form exhibits greater abscisic acid binding than the GTP-bound form.1 Publication

Enzyme regulationi

The GTPase activity is Mg2+ dependent and is strongly inhibited by the interaction with GPA1.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi382 – 41130GTP Inferred
Add
BLAST

GO - Molecular functioni

  1. GTP binding Source: TAIR
  2. GTPase binding Source: TAIR
  3. abscisic acid binding Source: TAIR
  4. protein binding Source: IntAct

GO - Biological processi

  1. post-embryonic development Source: TAIR
  2. response to abscisic acid Source: TAIR
  3. vegetative to reproductive phase transition of meristem Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GPCR-type G protein 1
Gene namesi
Name:GTG1
Ordered Locus Names:At1g64990
ORF Names:F13O11.29
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G64990.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei45 – 6521Helical; Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Transmembranei153 – 17321Helical; Reviewed prediction
Add
BLAST
Transmembranei297 – 31923Helical; Reviewed prediction
Add
BLAST
Transmembranei345 – 36521Helical; Reviewed prediction
Add
BLAST
Transmembranei389 – 40921Helical; Reviewed prediction
Add
BLAST
Transmembranei437 – 45721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular membrane-bounded organelle Source: TAIR
  3. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype; due to the redundancy with GTG2. Gtg1 and gtg2 double mutants are hyposensitive to abscisic acid.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468GPCR-type G protein 1
PRO_0000367058Add
BLAST

Proteomic databases

PaxDbiQ9XIP7.
PRIDEiQ9XIP7.

Expressioni

Tissue specificityi

Expressed in cotyledons, leaves, stems, roots, flowers and guard cells.1 Publication

Inductioni

Not induced by abscisic acid, cold, salt or drought treatments.1 Publication

Gene expression databases

GenevestigatoriQ9XIP7.

Interactioni

Subunit structurei

Interacts with GPA1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GPA1P180642EBI-2214605,EBI-443890

Protein-protein interaction databases

BioGridi28028. 1 interaction.
IntActiQ9XIP7. 1 interaction.
STRINGi3702.AT1G64990.2-P.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili243 – 27937 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi206 – 2094Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295277.
HOGENOMiHOG000240999.
InParanoidiQ9XIP7.
OMAiHLFAKWT.
PhylomeDBiQ9XIP7.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view]
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XIP7-1 [UniParc]FASTAAdd to Basket

« Hide

MSYGWAIYEG TVVIASLSLL GWAGLWFLNR RLYKEYEEKR ALVQIIFSVV    50
FAFSCNLLQL VLFEIIPVLS REARMINWKV DLFCLILLLV FMLPYYHCYL 100
MLRNSGVRRE RASVGAFLFL SAFLYAFWRM GVHFPMPSAD KGFFTMPQLV 150
SRIGVIGVTL MAVLSGFGAV NLPYSYISLF IREIEEADII SLERQLIQST 200
ETCIAKKKKI ILCQLEVERN QGSEENQKRS SFFRRIVGTV VRSVQDDQKE 250
QDIKILEAEV EALEELSKQL FLEVYELRQA KDAAAYSRTW KGHVQNLLGY 300
ACSIYCVYKM LKSLQSVVFK EAGTKDPVTT MISIFLRLFD IGVDAALLSQ 350
YISLLFIGML IVISVRGFLT NLMKFFFAVS RVGSGSSSNV VLFLSEIMGM 400
YFLSSILLIR KSLRNEYRGI ITDVLGGDIQ FDFYHRWFDA IFVASAFLSL 450
VLLSAHYTSR QSDKHAIE 468
Length:468
Mass (Da):53,546
Last modified:November 1, 1999 - v1
Checksum:iB267D260A6E4BF8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006193 Genomic DNA. Translation: AAD38272.1.
CP002684 Genomic DNA. Translation: AEE34312.1.
CP002684 Genomic DNA. Translation: AEE34313.1.
AY070446 mRNA. Translation: AAL49849.1.
PIRiE96673.
RefSeqiNP_001031235.1. NM_001036158.1.
NP_176679.2. NM_105173.3.
UniGeneiAt.28354.

Genome annotation databases

EnsemblPlantsiAT1G64990.1; AT1G64990.1; AT1G64990.
AT1G64990.2; AT1G64990.2; AT1G64990.
GeneIDi842807.
KEGGiath:AT1G64990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006193 Genomic DNA. Translation: AAD38272.1 .
CP002684 Genomic DNA. Translation: AEE34312.1 .
CP002684 Genomic DNA. Translation: AEE34313.1 .
AY070446 mRNA. Translation: AAL49849.1 .
PIRi E96673.
RefSeqi NP_001031235.1. NM_001036158.1.
NP_176679.2. NM_105173.3.
UniGenei At.28354.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 28028. 1 interaction.
IntActi Q9XIP7. 1 interaction.
STRINGi 3702.AT1G64990.2-P.

Proteomic databases

PaxDbi Q9XIP7.
PRIDEi Q9XIP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G64990.1 ; AT1G64990.1 ; AT1G64990 .
AT1G64990.2 ; AT1G64990.2 ; AT1G64990 .
GeneIDi 842807.
KEGGi ath:AT1G64990.

Organism-specific databases

TAIRi AT1G64990.

Phylogenomic databases

eggNOGi NOG295277.
HOGENOMi HOG000240999.
InParanoidi Q9XIP7.
OMAi HLFAKWT.
PhylomeDBi Q9XIP7.

Gene expression databases

Genevestigatori Q9XIP7.

Family and domain databases

InterProi IPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR.
[Graphical view ]
PANTHERi PTHR15948. PTHR15948. 1 hit.
Pfami PF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view ]
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis."
    Pandey S., Nelson D.C., Assmann S.M.
    Cell 136:136-148(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION, INTERACTION WITH GPA1, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiGTG1_ARATH
AccessioniPrimary (citable) accession number: Q9XIP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Has both a topology similar to GPCRs and a GTP-binding/GTPase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi