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Q9XIP7 (GTG1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GPCR-type G protein 1
Gene names
Name:GTG1
Ordered Locus Names:At1g64990
ORF Names:F13O11.29
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Abscisic acid receptor. The GDP-bound form exhibits greater abscisic acid binding than the GTP-bound form. Ref.4

Enzyme regulation

The GTPase activity is Mg2+ dependent and is strongly inhibited by the interaction with GPA1.

Subunit structure

Interacts with GPA1. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.4.

Tissue specificity

Expressed in cotyledons, leaves, stems, roots, flowers and guard cells. Ref.4

Induction

Not induced by abscisic acid, cold, salt or drought treatments. Ref.4

Disruption phenotype

No visible phenotype; due to the redundancy with GTG2. Gtg1 and gtg2 double mutants are hyposensitive to abscisic acid. Ref.4

Miscellaneous

Has both a topology similar to GPCRs and a GTP-binding/GTPase activity.

Sequence similarities

Belongs to the Golgi pH regulator (TC 1.A.38) family. [View classification]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GPA1P180642EBI-2214605,EBI-443890

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468GPCR-type G protein 1
PRO_0000367058

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane297 – 31923Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane389 – 40921Helical; Potential
Transmembrane437 – 45721Helical; Potential
Nucleotide binding382 – 41130GTP Probable
Coiled coil243 – 27937 Potential
Compositional bias206 – 2094Poly-Lys

Sequences

Sequence LengthMass (Da)Tools
Q9XIP7 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B267D260A6E4BF8B

FASTA46853,546
        10         20         30         40         50         60 
MSYGWAIYEG TVVIASLSLL GWAGLWFLNR RLYKEYEEKR ALVQIIFSVV FAFSCNLLQL 

        70         80         90        100        110        120 
VLFEIIPVLS REARMINWKV DLFCLILLLV FMLPYYHCYL MLRNSGVRRE RASVGAFLFL 

       130        140        150        160        170        180 
SAFLYAFWRM GVHFPMPSAD KGFFTMPQLV SRIGVIGVTL MAVLSGFGAV NLPYSYISLF 

       190        200        210        220        230        240 
IREIEEADII SLERQLIQST ETCIAKKKKI ILCQLEVERN QGSEENQKRS SFFRRIVGTV 

       250        260        270        280        290        300 
VRSVQDDQKE QDIKILEAEV EALEELSKQL FLEVYELRQA KDAAAYSRTW KGHVQNLLGY 

       310        320        330        340        350        360 
ACSIYCVYKM LKSLQSVVFK EAGTKDPVTT MISIFLRLFD IGVDAALLSQ YISLLFIGML 

       370        380        390        400        410        420 
IVISVRGFLT NLMKFFFAVS RVGSGSSSNV VLFLSEIMGM YFLSSILLIR KSLRNEYRGI 

       430        440        450        460 
ITDVLGGDIQ FDFYHRWFDA IFVASAFLSL VLLSAHYTSR QSDKHAIE 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis."
Pandey S., Nelson D.C., Assmann S.M.
Cell 136:136-148(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION, INTERACTION WITH GPA1, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC006193 Genomic DNA. Translation: AAD38272.1.
CP002684 Genomic DNA. Translation: AEE34312.1.
CP002684 Genomic DNA. Translation: AEE34313.1.
AY070446 mRNA. Translation: AAL49849.1.
PIRE96673.
RefSeqNP_001031235.1. NM_001036158.1.
NP_176679.2. NM_105173.3.
UniGeneAt.28354.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid28028. 1 interaction.
IntActQ9XIP7. 1 interaction.
STRING3702.AT1G64990.2-P.

Proteomic databases

PaxDbQ9XIP7.
PRIDEQ9XIP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G64990.1; AT1G64990.1; AT1G64990.
AT1G64990.2; AT1G64990.2; AT1G64990.
GeneID842807.
KEGGath:AT1G64990.

Organism-specific databases

TAIRAT1G64990.

Phylogenomic databases

eggNOGNOG295277.
HOGENOMHOG000240999.
InParanoidQ9XIP7.
OMAHLFAKWT.
PhylomeDBQ9XIP7.

Gene expression databases

GenevestigatorQ9XIP7.

Family and domain databases

InterProIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR.
[Graphical view]
PANTHERPTHR15948. PTHR15948. 1 hit.
PfamPF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGTG1_ARATH
AccessionPrimary (citable) accession number: Q9XIP7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names