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Q9XIP7

- GTG1_ARATH

UniProt

Q9XIP7 - GTG1_ARATH

Protein

GPCR-type G protein 1

Gene

GTG1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Abscisic acid receptor. The GDP-bound form exhibits greater abscisic acid binding than the GTP-bound form.1 Publication

    Enzyme regulationi

    The GTPase activity is Mg2+ dependent and is strongly inhibited by the interaction with GPA1.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi382 – 41130GTPCuratedAdd
    BLAST

    GO - Molecular functioni

    1. abscisic acid binding Source: TAIR
    2. GTPase binding Source: TAIR
    3. GTP binding Source: TAIR
    4. protein binding Source: IntAct

    GO - Biological processi

    1. post-embryonic development Source: TAIR
    2. response to abscisic acid Source: TAIR
    3. vegetative to reproductive phase transition of meristem Source: TAIR

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GPCR-type G protein 1
    Gene namesi
    Name:GTG1
    Ordered Locus Names:At1g64990
    ORF Names:F13O11.29
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G64990.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular membrane-bounded organelle Source: TAIR
    3. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype; due to the redundancy with GTG2. Gtg1 and gtg2 double mutants are hyposensitive to abscisic acid.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468GPCR-type G protein 1PRO_0000367058Add
    BLAST

    Proteomic databases

    PaxDbiQ9XIP7.
    PRIDEiQ9XIP7.

    Expressioni

    Tissue specificityi

    Expressed in cotyledons, leaves, stems, roots, flowers and guard cells.1 Publication

    Inductioni

    Not induced by abscisic acid, cold, salt or drought treatments.1 Publication

    Gene expression databases

    GenevestigatoriQ9XIP7.

    Interactioni

    Subunit structurei

    Interacts with GPA1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GPA1P180642EBI-2214605,EBI-443890

    Protein-protein interaction databases

    BioGridi28028. 1 interaction.
    IntActiQ9XIP7. 1 interaction.
    STRINGi3702.AT1G64990.2-P.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei389 – 40921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili243 – 27937Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi206 – 2094Poly-Lys

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295277.
    HOGENOMiHOG000240999.
    InParanoidiQ9XIP7.
    OMAiHLFAKWT.
    PhylomeDBiQ9XIP7.

    Family and domain databases

    InterProiIPR025969. ABA_GPCR_dom.
    IPR022535. Golgi_pH-regulator_cons_dom.
    IPR015672. GPHR.
    [Graphical view]
    PANTHERiPTHR15948. PTHR15948. 1 hit.
    PfamiPF12430. ABA_GPCR. 1 hit.
    PF12537. DUF3735. 1 hit.
    [Graphical view]
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XIP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYGWAIYEG TVVIASLSLL GWAGLWFLNR RLYKEYEEKR ALVQIIFSVV    50
    FAFSCNLLQL VLFEIIPVLS REARMINWKV DLFCLILLLV FMLPYYHCYL 100
    MLRNSGVRRE RASVGAFLFL SAFLYAFWRM GVHFPMPSAD KGFFTMPQLV 150
    SRIGVIGVTL MAVLSGFGAV NLPYSYISLF IREIEEADII SLERQLIQST 200
    ETCIAKKKKI ILCQLEVERN QGSEENQKRS SFFRRIVGTV VRSVQDDQKE 250
    QDIKILEAEV EALEELSKQL FLEVYELRQA KDAAAYSRTW KGHVQNLLGY 300
    ACSIYCVYKM LKSLQSVVFK EAGTKDPVTT MISIFLRLFD IGVDAALLSQ 350
    YISLLFIGML IVISVRGFLT NLMKFFFAVS RVGSGSSSNV VLFLSEIMGM 400
    YFLSSILLIR KSLRNEYRGI ITDVLGGDIQ FDFYHRWFDA IFVASAFLSL 450
    VLLSAHYTSR QSDKHAIE 468
    Length:468
    Mass (Da):53,546
    Last modified:November 1, 1999 - v1
    Checksum:iB267D260A6E4BF8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006193 Genomic DNA. Translation: AAD38272.1.
    CP002684 Genomic DNA. Translation: AEE34312.1.
    CP002684 Genomic DNA. Translation: AEE34313.1.
    AY070446 mRNA. Translation: AAL49849.1.
    PIRiE96673.
    RefSeqiNP_001031235.1. NM_001036158.1.
    NP_176679.2. NM_105173.3.
    UniGeneiAt.28354.

    Genome annotation databases

    EnsemblPlantsiAT1G64990.1; AT1G64990.1; AT1G64990.
    AT1G64990.2; AT1G64990.2; AT1G64990.
    GeneIDi842807.
    KEGGiath:AT1G64990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006193 Genomic DNA. Translation: AAD38272.1 .
    CP002684 Genomic DNA. Translation: AEE34312.1 .
    CP002684 Genomic DNA. Translation: AEE34313.1 .
    AY070446 mRNA. Translation: AAL49849.1 .
    PIRi E96673.
    RefSeqi NP_001031235.1. NM_001036158.1.
    NP_176679.2. NM_105173.3.
    UniGenei At.28354.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 28028. 1 interaction.
    IntActi Q9XIP7. 1 interaction.
    STRINGi 3702.AT1G64990.2-P.

    Proteomic databases

    PaxDbi Q9XIP7.
    PRIDEi Q9XIP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G64990.1 ; AT1G64990.1 ; AT1G64990 .
    AT1G64990.2 ; AT1G64990.2 ; AT1G64990 .
    GeneIDi 842807.
    KEGGi ath:AT1G64990.

    Organism-specific databases

    TAIRi AT1G64990.

    Phylogenomic databases

    eggNOGi NOG295277.
    HOGENOMi HOG000240999.
    InParanoidi Q9XIP7.
    OMAi HLFAKWT.
    PhylomeDBi Q9XIP7.

    Gene expression databases

    Genevestigatori Q9XIP7.

    Family and domain databases

    InterProi IPR025969. ABA_GPCR_dom.
    IPR022535. Golgi_pH-regulator_cons_dom.
    IPR015672. GPHR.
    [Graphical view ]
    PANTHERi PTHR15948. PTHR15948. 1 hit.
    Pfami PF12430. ABA_GPCR. 1 hit.
    PF12537. DUF3735. 1 hit.
    [Graphical view ]
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis."
      Pandey S., Nelson D.C., Assmann S.M.
      Cell 136:136-148(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION, INTERACTION WITH GPA1, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiGTG1_ARATH
    AccessioniPrimary (citable) accession number: Q9XIP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has both a topology similar to GPCRs and a GTP-binding/GTPase activity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3