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Protein

ABC transporter G family member 36

Gene

ABCG36

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key factor that controls the extent of cell death in the defense response. Necessary for both callose deposition and glucosinolate activation in response to pathogens. Required for limiting invasion by nonadapted powdery mildews. Confers resistance to cadmium (Cd) and lead (Pb), probably as an efflux pump of Cd2+ or Cd conjugates, and possibly, of chemicals that mediate pathogen resistance.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 211ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi912 – 919ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cadmium ion transport Source: TAIR
  • cellular response to indolebutyric acid stimulus Source: TAIR
  • defense response by callose deposition in cell wall Source: TAIR
  • defense response to bacterium Source: TAIR
  • defense response to fungus, incompatible interaction Source: TAIR
  • drug transmembrane transport Source: TAIR
  • indole glucosinolate catabolic process Source: TAIR
  • negative regulation of defense response Source: TAIR
  • response to abscisic acid Source: TAIR
  • systemic acquired resistance Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Plant defense, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.205.9. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter G family member 36
Short name:
ABC transporter ABCG.36
Short name:
AtABCG36
Alternative name(s):
Pleiotropic drug resistance protein 8
Protein PENETRATION 3
Gene namesi
Name:ABCG36
Synonyms:PDR8, PEN3
Ordered Locus Names:At1g59870
ORF Names:F23H11.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G59870.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei540 – 560HelicalSequence analysisAdd BLAST21
Transmembranei575 – 595HelicalSequence analysisAdd BLAST21
Transmembranei621 – 641HelicalSequence analysisAdd BLAST21
Transmembranei659 – 679HelicalSequence analysisAdd BLAST21
Transmembranei685 – 705HelicalSequence analysisAdd BLAST21
Transmembranei713 – 733HelicalSequence analysisAdd BLAST21
Transmembranei772 – 792HelicalSequence analysisAdd BLAST21
Transmembranei1216 – 1236HelicalSequence analysisAdd BLAST21
Transmembranei1239 – 1259HelicalSequence analysisAdd BLAST21
Transmembranei1299 – 1319HelicalSequence analysisAdd BLAST21
Transmembranei1326 – 1346HelicalSequence analysisAdd BLAST21
Transmembranei1356 – 1376HelicalSequence analysisAdd BLAST21
Transmembranei1384 – 1404HelicalSequence analysisAdd BLAST21
Transmembranei1441 – 1461HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast envelope Source: TAIR
  • integral component of membrane Source: GO_Central
  • membrane Source: TAIR
  • mitochondrion Source: TAIR
  • plasma membrane Source: TAIR
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Less sensitive to compatible pathogens (P.syringae pv tomato) due to accelerated cell death and lesion formation.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi354G → D in pen3-1; more susceptible to Plectosphaerella cucumerina, with higher frequency of fungal penetration and increased formation of elongating secondary hyphae after the first haustorium development. 1 Publication1
Mutagenesisi915G → S in pen3-2; more susceptible to P. cucumerina, with higher frequency of fungal penetration and increased formation of elongating secondary hyphae after the first haustorium development. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002346351 – 1469ABC transporter G family member 36Add BLAST1469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei43PhosphothreonineCombined sources1
Modified residuei45PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9XIE2.
PRIDEiQ9XIE2.

PTM databases

iPTMnetiQ9XIE2.
SwissPalmiQ9XIE2.

Expressioni

Tissue specificityi

Ubiquitous (at protein level). Higher levels in root hairs, stomata, epidermal cells, and hydathodes. Concentrated at the infection site of infected plants, including papillae and haustoria.4 Publications

Inductioni

Induced by cycloheximide (CHX), cold/dark treatment, cadmium, lead, sclareol and sclareolide. Repressed by abscisic acid (ABA). Induced by infection of avirulent and virulent bacterial pathogens (P.syringae pv tomato with or without avrRpt2, respectively) and fungal pathogens.4 Publications

Gene expression databases

GenevisibleiQ9XIE2. AT.

Interactioni

Protein-protein interaction databases

BioGridi27506. 30 interactors.
STRINGi3702.AT1G59870.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XIE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini171 – 444ABC transporter 1PROSITE-ProRule annotationAdd BLAST274
Domaini522 – 735ABC transmembrane type-2 1Add BLAST214
Domaini867 – 1119ABC transporter 2PROSITE-ProRule annotationAdd BLAST253
Domaini1192 – 1406ABC transmembrane type-2 2Add BLAST215

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0065. Eukaryota.
COG0842. LUCA.
HOGENOMiHOG000238051.
InParanoidiQ9XIE2.
OMAiPSESHIC.
OrthoDBiEOG09360089.
PhylomeDBiQ9XIE2.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR013581. PDR_assoc.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF08370. PDR_assoc. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XIE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYNPNLPPL GGGGVSMRRS ISRSVSRASR NIEDIFSSGS RRTQSVNDDE
60 70 80 90 100
EALKWAAIEK LPTYSRLRTT LMNAVVEDDV YGNQLMSKEV DVTKLDGEDR
110 120 130 140 150
QKFIDMVFKV AEQDNERILT KLRNRIDRVG IKLPTVEVRY EHLTIKADCY
160 170 180 190 200
TGNRSLPTLL NVVRNMGESA LGMIGIQFAK KAQLTILKDI SGVIKPGRMT
210 220 230 240 250
LLLGPPSSGK TTLLLALAGK LDKSLQVSGD ITYNGYQLDE FVPRKTSAYI
260 270 280 290 300
SQNDLHVGIM TVKETLDFSA RCQGVGTRYD LLNELARREK DAGIFPEADV
310 320 330 340 350
DLFMKASAAQ GVKNSLVTDY TLKILGLDIC KDTIVGDDMM RGISGGQKKR
360 370 380 390 400
VTTGEMIVGP TKTLFMDEIS TGLDSSTTFQ IVKCLQQIVH LNEATVLMSL
410 420 430 440 450
LQPAPETFDL FDDIILVSEG QIVYQGPRDN ILEFFESFGF KCPERKGTAD
460 470 480 490 500
FLQEVTSKKD QEQYWVNPNR PYHYIPVSEF ASRYKSFHVG TKMSNELAVP
510 520 530 540 550
FDKSRGHKAA LVFDKYSVSK RELLKSCWDK EWLLMQRNAF FYVFKTVQIV
560 570 580 590 600
IIAAITSTLF LRTEMNTRNE GDANLYIGAL LFGMIINMFN GFAEMAMMVS
610 620 630 640 650
RLPVFYKQRD LLFYPSWTFS LPTFLLGIPS SILESTAWMV VTYYSIGFAP
660 670 680 690 700
DASRFFKQFL LVFLIQQMAA SLFRLIASVC RTMMIANTGG ALTLLLVFLL
710 720 730 740 750
GGFLLPKGKI PDWWGWAYWV SPLTYAFNGL VVNEMFAPRW MNKMASSNST
760 770 780 790 800
IKLGTMVLNT WDVYHQKNWY WISVGALLCF TALFNILFTL ALTYLNPLGK
810 820 830 840 850
KAGLLPEEEN EDADQGKDPM RRSLSTADGN RRGEVAMGRM SRDSAAEASG
860 870 880 890 900
GAGNKKGMVL PFTPLAMSFD DVKYFVDMPG EMRDQGVTET RLQLLKGVTG
910 920 930 940 950
AFRPGVLTAL MGVSGAGKTT LMDVLAGRKT GGYIEGDVRI SGFPKVQETF
960 970 980 990 1000
ARISGYCEQT DIHSPQVTVR ESLIFSAFLR LPKEVGKDEK MMFVDQVMEL
1010 1020 1030 1040 1050
VELDSLRDSI VGLPGVTGLS TEQRKRLTIA VELVANPSII FMDEPTSGLD
1060 1070 1080 1090 1100
ARAAAIVMRA VRNTVDTGRT VVCTIHQPSI DIFEAFDELM LMKRGGQVIY
1110 1120 1130 1140 1150
AGPLGQNSHK VVEYFESFPG VSKIPEKYNP ATWMLEASSL AAELKLSVDF
1160 1170 1180 1190 1200
AELYNQSALH QRNKALVKEL SVPPAGASDL YFATQFSQNT WGQFKSCLWK
1210 1220 1230 1240 1250
QWWTYWRSPD YNLVRFIFTL ATSLLIGTVF WQIGGNRSNA GDLTMVIGAL
1260 1270 1280 1290 1300
YAAIIFVGIN NCSTVQPMVA VERTVFYRER AAGMYSAMPY AISQVTCELP
1310 1320 1330 1340 1350
YVLIQTVYYS LIVYAMVGFE WKAEKFFWFV FVSYFSFLYW TYYGMMTVSL
1360 1370 1380 1390 1400
TPNQQVASIF ASAFYGIFNL FSGFFIPRPK IPKWWIWYYW ICPVAWTVYG
1410 1420 1430 1440 1450
LIVSQYGDVE TRIQVLGGAP DLTVKQYIED HYGFQSDFMG PVAAVLIAFT
1460
VFFAFIFAFC IRTLNFQTR
Length:1,469
Mass (Da):165,082
Last modified:November 1, 1999 - v1
Checksum:i54B39B2EEAAEED07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007258 Genomic DNA. Translation: AAD39329.1.
CP002684 Genomic DNA. Translation: AEE33632.1.
AY074515 mRNA. Translation: AAL67129.1.
BK001007 Genomic DNA. Translation: DAA00876.1.
PIRiH96622.
RefSeqiNP_176196.1. NM_104680.3.
UniGeneiAt.24243.

Genome annotation databases

EnsemblPlantsiAT1G59870.1; AT1G59870.1; AT1G59870.
GeneIDi842281.
GrameneiAT1G59870.1; AT1G59870.1; AT1G59870.
KEGGiath:AT1G59870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007258 Genomic DNA. Translation: AAD39329.1.
CP002684 Genomic DNA. Translation: AEE33632.1.
AY074515 mRNA. Translation: AAL67129.1.
BK001007 Genomic DNA. Translation: DAA00876.1.
PIRiH96622.
RefSeqiNP_176196.1. NM_104680.3.
UniGeneiAt.24243.

3D structure databases

ProteinModelPortaliQ9XIE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27506. 30 interactors.
STRINGi3702.AT1G59870.1.

Protein family/group databases

TCDBi3.A.1.205.9. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ9XIE2.
SwissPalmiQ9XIE2.

Proteomic databases

PaxDbiQ9XIE2.
PRIDEiQ9XIE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G59870.1; AT1G59870.1; AT1G59870.
GeneIDi842281.
GrameneiAT1G59870.1; AT1G59870.1; AT1G59870.
KEGGiath:AT1G59870.

Organism-specific databases

TAIRiAT1G59870.

Phylogenomic databases

eggNOGiKOG0065. Eukaryota.
COG0842. LUCA.
HOGENOMiHOG000238051.
InParanoidiQ9XIE2.
OMAiPSESHIC.
OrthoDBiEOG09360089.
PhylomeDBiQ9XIE2.

Miscellaneous databases

PROiQ9XIE2.

Gene expression databases

GenevisibleiQ9XIE2. AT.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR013581. PDR_assoc.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF08370. PDR_assoc. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAB36G_ARATH
AccessioniPrimary (citable) accession number: Q9XIE2
Secondary accession number(s): Q8VXW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.