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Protein

Eukaryotic translation initiation factor 5A-1

Gene

ELF5A-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The precise role of eIF-5A in protein biosynthesis is not known but it may function as a bimodular protein capable of binding to both RNA and proteins. Involved in xylogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-ATH-204626 Hypusine synthesis from eIF5A-lysine

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-1
Short name:
AtELF5A-1
Short name:
eIF-5A-1
Gene namesi
Name:ELF5A-1
Ordered Locus Names:At1g13950
ORF Names:F16A14.17, F7A19.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G13950
TAIRilocus:2014784 AT1G13950

Pathology & Biotechi

Disruption phenotypei

No visible phenotype, but presence of extra root protoxylem cell files.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001424631 – 158Eukaryotic translation initiation factor 5A-1Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei51Hypusine1 Publication1

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMi

Hypusine, Phosphoprotein

Proteomic databases

PaxDbiQ9XI91
PRIDEiQ9XI91

Expressioni

Tissue specificityi

Expressed in leaf vasculature and inflorescence stems. Present in xylem tissue but not in phloem, and in developing vessel members, but not in mature vessels members. Detected in anthers.3 Publications

Developmental stagei

Increases at the onset of leaf senescence.1 Publication

Inductioni

Up-regulated at post-transcriptional level by iron deficiency.2 Publications

Gene expression databases

ExpressionAtlasiQ9XI91 baseline and differential
GenevisibleiQ9XI91 AT

Interactioni

Protein-protein interaction databases

BioGridi23195, 1 interactor
STRINGi3702.AT1G13950.1

Structurei

3D structure databases

ProteinModelPortaliQ9XI91
SMRiQ9XI91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
HOGENOMiHOG000106270
InParanoidiQ9XI91
KOiK03263
OMAiCVIAIKT
OrthoDBiEOG09360PFE
PhylomeDBiQ9XI91

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XI91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEEHHFES SDAGASKTYP QQAGTIRKNG YIVIKNRPCK VVEVSTSKTG
60 70 80 90 100
KHGHAKCHFV AIDIFTSKKL EDIVPSSHNC DVPHVNRTDY QLIDISEDGY
110 120 130 140 150
VSLLTDNGST KDDLKLPNDD TLLQQIKSGF DDGKDLVVSV MSAMGEEQIN

ALKDIGPK
Length:158
Mass (Da):17,360
Last modified:November 1, 1999 - v1
Checksum:iDD837BD71E2DEC7D
GO

Sequence cautioni

The sequence AAF79401 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296082 mRNA Translation: AAG53646.1
AC007576 Genomic DNA Translation: AAD39281.1
AC068197 Genomic DNA Translation: AAF79401.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29088.1
AY063780 mRNA Translation: AAL36087.1
AY117272 mRNA Translation: AAM51347.1
PIRiF86272
RefSeqiNP_172848.1, NM_101261.3
UniGeneiAt.24908

Genome annotation databases

EnsemblPlantsiAT1G13950.1; AT1G13950.1; AT1G13950
GeneIDi837955
GrameneiAT1G13950.1; AT1G13950.1; AT1G13950
KEGGiath:AT1G13950

Similar proteinsi

Entry informationi

Entry nameiIF5A1_ARATH
AccessioniPrimary (citable) accession number: Q9XI91
Secondary accession number(s): Q9LMG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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