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Protein

SWI/SNF complex subunit SWI3C

Gene

SWI3C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of a multiprotein complex equivalent of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF complex subunit SWI3C
Short name:
AtSWI3C
Alternative name(s):
Transcription regulatory protein SWI3C
Gene namesi
Name:SWI3C
Synonyms:CHB4
Ordered Locus Names:At1g21700
ORF Names:F8K7.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G21700.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • SWI/SNF complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Plants are viable but have alterations in leaf, root and flower development, and are early flowering.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807SWI/SNF complex subunit SWI3CPRO_0000344529Add
BLAST

Proteomic databases

PaxDbiQ9XI07.
PRIDEiQ9XI07.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Gene expression databases

GenevisibleiQ9XI07. AT.

Interactioni

Subunit structurei

Heterodimer. Interacts with SWI3A, SWI3B and BRM, but not with BSH.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SWI3BQ84JG24EBI-1102300,EBI-1102271

Protein-protein interaction databases

BioGridi24013. 142 interactions.
DIPiDIP-37816N.
IntActiQ9XI07. 4 interactions.
STRINGi3702.AT1G21700.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XI07.
SMRiQ9XI07. Positions 182-265, 393-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 27499SWIRMPROSITE-ProRule annotationAdd
BLAST
Domaini398 – 44952SANTPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili598 – 65659Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 5528Glu-richAdd
BLAST
Compositional biasi39 – 446Poly-Asn
Compositional biasi691 – 73949Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 SANT domain.PROSITE-ProRule annotation
Contains 1 SWIRM domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1279. Eukaryota.
COG5259. LUCA.
HOGENOMiHOG000243996.
InParanoidiQ9XI07.
KOiK11649.
OMAiCEQVERV.
PhylomeDBiQ9XI07.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR032451. SMARCC_C.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
PF16495. SWIRM-assoc_1. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XI07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASEDRRGK WKRKKRGGLS AARKPKQEEE DMEEEDEENN NNNNEEMDDV
60 70 80 90 100
ENADELQQNG GATPDPGLGI GEVVEDSGSR ISDFPAVVKR VVIRPHASVM
110 120 130 140 150
AVVAAERAGL IGETRGQGSL PALENISFGQ LQALSTVPAD SLDLERSDGS
160 170 180 190 200
SSAYVISPPP IMDGEGVVKR FGDLVHVLPM HSDWFAPNTV DRLERQVVPQ
210 220 230 240 250
FFSGKSPNHT PESYMEFRNA IVSKYVENPE KTLTISDCQG LVDGVDIEDF
260 270 280 290 300
ARVFRFLDHW GIINYCATAQ SHPGPLRDVS DVREDTNGEV NVPSAALTSI
310 320 330 340 350
DSLIKFDKPN CRHKGGEVYS SLPSLDGDSP DLDIRIREHL CDSHCNHCSR
360 370 380 390 400
PLPTVYFQSQ KKGDILLCCD CFHHGRFVVG HSCLDFVRVD PMKFYGDQDG
410 420 430 440 450
DNWTDQETLL LLEAVELYNE NWVQIADHVG SKSKAQCILH FLRLPVEDGL
460 470 480 490 500
LDNVEVSGVT NTENPTNGYD HKGTDSNGDL PGYSEQGSDT EIKLPFVKSP
510 520 530 540 550
NPVMALVAFL ASAVGPRVAA SCAHESLSVL SEDDRMKSEG MQGKEASLLD
560 570 580 590 600
GENQQQDGAH KTSSQNGAEA QTPLPQDKVM AAFRAGLSAA ATKAKLFADH
610 620 630 640 650
EEREIQRLSA NIVNHQLKRM ELKLKQFAEI ETLLMKECEQ VEKTRQRFSA
660 670 680 690 700
ERARMLSARF GSPGGISPQT NNLQGMSLST GGNNINSLMH QQHQQQQASA
710 720 730 740 750
TSQPSIIPGF SNNPQVQAQM HFMARQQQQQ QQQQQQQQQA FSFGPRLPLN
760 770 780 790 800
AIQTNAGSTA SPNVMFGNNQ LNNPAAAGAA SINQPSFSHP MVRSSTGSGS

GSGLGLN
Length:807
Mass (Da):88,250
Last modified:November 1, 1999 - v1
Checksum:iDAB17C104E4B287F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007727 Genomic DNA. Translation: AAD41423.1.
CP002684 Genomic DNA. Translation: AEE30144.1.
AY091026 mRNA. Translation: AAM13847.1.
AY117245 mRNA. Translation: AAM51320.1.
PIRiD86350.
RefSeqiNP_173589.1. NM_102019.3.
UniGeneiAt.41645.

Genome annotation databases

EnsemblPlantsiAT1G21700.1; AT1G21700.1; AT1G21700.
GeneIDi838774.
GrameneiAT1G21700.1; AT1G21700.1; AT1G21700.
KEGGiath:AT1G21700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007727 Genomic DNA. Translation: AAD41423.1.
CP002684 Genomic DNA. Translation: AEE30144.1.
AY091026 mRNA. Translation: AAM13847.1.
AY117245 mRNA. Translation: AAM51320.1.
PIRiD86350.
RefSeqiNP_173589.1. NM_102019.3.
UniGeneiAt.41645.

3D structure databases

ProteinModelPortaliQ9XI07.
SMRiQ9XI07. Positions 182-265, 393-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24013. 142 interactions.
DIPiDIP-37816N.
IntActiQ9XI07. 4 interactions.
STRINGi3702.AT1G21700.1.

Proteomic databases

PaxDbiQ9XI07.
PRIDEiQ9XI07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G21700.1; AT1G21700.1; AT1G21700.
GeneIDi838774.
GrameneiAT1G21700.1; AT1G21700.1; AT1G21700.
KEGGiath:AT1G21700.

Organism-specific databases

TAIRiAT1G21700.

Phylogenomic databases

eggNOGiKOG1279. Eukaryota.
COG5259. LUCA.
HOGENOMiHOG000243996.
InParanoidiQ9XI07.
KOiK11649.
OMAiCEQVERV.
PhylomeDBiQ9XI07.

Miscellaneous databases

PROiQ9XI07.

Gene expression databases

GenevisibleiQ9XI07. AT.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR032451. SMARCC_C.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
PF16495. SWIRM-assoc_1. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "AtSWI3B, an Arabidopsis homolog of SWI3, a core subunit of yeast Swi/Snf chromatin remodeling complex, interacts with FCA, a regulator of flowering time."
    Sarnowski T.J., Swiezewski S., Pawlikowska K., Kaczanowski S., Jerzmanowski A.
    Nucleic Acids Res. 30:3412-3421(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SWI3B.
  5. "CHB2, a member of the SWI3 gene family, is a global regulator in Arabidopsis."
    Zhou C., Miki B., Wu K.
    Plant Mol. Biol. 52:1125-1134(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "The Arabidopsis thaliana SNF2 homolog AtBRM controls shoot development and flowering."
    Farrona S., Hurtado L., Bowman J.L., Reyes J.C.
    Development 131:4965-4975(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BRM.
  7. "SWI3 subunits of putative SWI/SNF chromatin-remodeling complexes play distinct roles during Arabidopsis development."
    Sarnowski T.J., Rios G., Jasik J., Swiezewski S., Kaczanowski S., Li Y., Kwiatkowska A., Pawlikowska K., Kozbial M., Kozbial P., Koncz C., Jerzmanowski A.
    Plant Cell 17:2454-2472(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH SWI3A AND BSH.

Entry informationi

Entry nameiSWI3C_ARATH
AccessioniPrimary (citable) accession number: Q9XI07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.