Q9XHY7 (HACL3_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable histone acetyltransferase HAC-like 3
EC=2.3.1.48

Gene names

Ordered Locus Names:	Os01g0246100, Loc_Os01g14370
ORF Names:	OSJNBa0049B20.5, OSJNBa0004G10.16

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	1276 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 PHD-type zinc finger. Contains 1 TAZ-type zinc finger. Contains 2 ZZ-type zinc fingers.
Caution	It is uncertain whether Met-1 or Met-2 is the initiator.
Sequence caution	The sequence AAD38279.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAE95818.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Coiled coil Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Activator Acyltransferase Chromatin regulator Transferase
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC transcription cofactor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1276	1276	Probable histone acetyltransferase HAC-like 3		PRO_0000269747
Regions
	Zinc finger	621 – 689	69	PHD-type
	Zinc finger	1012 – 1059	48	ZZ-type 1
	Zinc finger	1124 – 1171	48	ZZ-type 2
	Zinc finger	1177 – 1260	84	TAZ-type
	Coiled coil	953 – 973	21	Potential
	Compositional bias	234 – 247	14	Ser-rich
	Compositional bias	1130 – 1157	28	Cys-rich
Experimental info
	Sequence conflict	468	1	P → Q Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9XHY7 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 902E2A329079778E	FASTA	1,276	145,098
	10 20 30 40 50 60 MMAKTLQGTQ QQYAASGFPT QQYPTSGWTQ SAAEILQLDN MDQDTSVVRN IIHRKIVEYL 70 80 90 100 110 120 NERKEFCNFD LSFLMEIGKC IDRHLFEKAD SKIKYMDLET LRTRLNAIVN SASFRGSMFH 130 140 150 160 170 180 WSASAASSKL NSQQLPVMEV PIYHDRVTPG PNNLPSCAYN VSSTQGYNQY ENCMGAANFA 190 200 210 220 230 240 HSLADKPKQM PERLANTIFT SCASTLPKCS PSIDVLHIGH IKEHFSGDAY QNDSSQPSTS 250 260 270 280 290 300 GSSSSLSAVW DQTTCSSAMR TLPMDSFSTV NGQNLSTNNK SLYPTTGQGP LLQQYIECEM 310 320 330 340 350 360 KQETWSRSLE QSDQSNITTG NRDLYHAQIH PYINGEHKRD RCIQMKEKLG HTSDHEGFSR 370 380 390 400 410 420 EKSSNLSNHF MHHQQGFMTN YGACSPVSKT VDRAEQTSNS TVSKPTSPAS DGSSGKHYPA 430 440 450 460 470 480 KRLKVDVPHL VHVNEMEASK EQQPAANETY ASAETVQSEV TNSPTKSPCC TSLGDNIACT 490 500 510 520 530 540 DNVHGMDMVR LSGSAVQTEE EFRRENSDIE MKDAKVDLLD QTLSGDSLRA RKRRGASVLY 550 560 570 580 590 600 ALTSEELKDH LCTLNHDTSQ SKVPTEELLS VEGLPDQNTC NLCGMERLLF EPPPRFCALC 610 620 630 640 650 660 FKIINSTGSY YVEVENGNDK SSICGRCHHL SSAKAKYQKR FSYAETDAEA EWWVQCDKCK 670 680 690 700 710 720 AWQHQICALF NPKIVDPEAE YTCAKCFLKE KDNEDVDSLE PSTILGAREL PRTRLSDHIE 730 740 750 760 770 780 QRLSERLVQE RQQRAIASGK SVDEVPGVEG LTVRVVSSAD RTLQVQPRFK DFFKKEQYPG 790 800 810 820 830 840 EFPYKSKAIL LFQKNEGVDV CLFAMYVQEY GSACPSPNQR HVYLAYIDSV KYFRPEIKSA 850 860 870 880 890 900 SGEALRTFVY HEILIGYLDF CKKRGFVSCS IWTCPSTKRD DYVLYCHPTI QKMPKSDKLR 910 920 930 940 950 960 SWYQNLVKKA VKEGVVVERN TLYDFFLQPT NECKTNISAA WLPYCDNDFW PGEAERLLEK 970 980 990 1000 1010 1020 KDDDTSQKKE TQLGRLLRVA KRDDRKGNLE DILLVHKLGE RLRTMKEDFL MLCLQQFCKH 1030 1040 1050 1060 1070 1080 CHHPIVSGSS WVCTSCKNFF LCERCYAEEL NTPLKDRHPA TTKQKHAFER IEEEPLPETD 1090 1100 1110 1120 1130 1140 DVDPTMESKY FDSRIDFLKH CQDNQYQFDT LRRAKHSTMM ILYHLHDSTC SSCHRAMDQC 1150 1160 1170 1180 1190 1200 LAWRCLVCLG CNFCDSCYKQ DGESLHIHKL RQKKDHHVLQ KYTLQDYLEG LVHASRCFDR 1210 1220 1230 1240 1250 1260 SCTSKLCLTL KKLFFHGVRC HTRARGGGGC HMCVFMWKLL FTHSLLCDNA DCSAPRCRDI 1270 KAYIADRSMT DLSISG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T. Nature 420:312-316(2002) [PubMed: 12447438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[4]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC007789 Genomic DNA. Translation: AAD38279.1. Sequence problems. AP003074 Genomic DNA. Translation: BAE95818.1. Different initiation. AP008207 Genomic DNA. Translation: BAF04486.1. AK120732 mRNA. No translation available.
RefSeq	NP_001042572.1. NM_001049107.1.
UniGene	Os.15122.
3D structure databases
ProteinModelPortal	Q9XHY7.
ModBase	Search...
Proteomic databases
PRIDE	Q9XHY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os01g14370.2; LOC_Os01g14370.2; LOC_Os01g14370.
GeneID	4326755.
KEGG	osa:4326755.
Organism-specific databases
Gramene	Q9XHY7.
Phylogenomic databases
GeneTree	EPGT00050000000620.
HOGENOM	HBG590006.
PhylomeDB	Q9XHY7.
ProtClustDB	CLSN2691281.
Family and domain databases
InterPro	IPR013178. Histone_H3-K56_AcTrfase_RTT109. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR013083. Znf_RING/FYVE/PHD. IPR000197. Znf_TAZ. IPR000433. Znf_ZZ. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit. G3DSA:1.20.1020.10. Znf_TAZ. 1 hit.
KO	K04498.
Pfam	PF08214. KAT11. 1 hit. PF02135. zf-TAZ. 1 hit. [Graphical view]
SMART	SM00249. PHD. 1 hit. SM00291. ZnF_ZZ. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit. SSF57933. TAZ_finger. 1 hit.
PROSITE	PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. False negative. PS50134. ZF_TAZ. 1 hit. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HACL3_ORYSJ

Accession

Primary (citable) accession number: Q9XHY7
Secondary accession number(s): Q0JP42, Q1EHS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program