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Protein

Cytochrome P450 71D13

Gene

CYP71D13

Organism
Mentha piperita (Peppermint) (Mentha aquatica x Mentha spicata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydroxylates (-)-(4S)-limonene to (-)-trans-isopiperitenol, a precursor of (-)-menthol, responsible for the cooling sensation of peppermint.2 Publications

Catalytic activityi

--(S)-limonene + NADPH + O2 = (-)-trans-isopiperitenol + NADP+ + H2O.2 Publications

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi439Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • (S)-limonene 3-monooxygenase activity Source: UniProtKB
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-6762

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 71D13 (EC:1.14.13.47)
Alternative name(s):
(-)-(4S)-Limonene-3-hydroxylase
Cytochrome P450 isoform PM17
Gene namesi
Name:CYP71D13
OrganismiMentha piperita (Peppermint) (Mentha aquatica x Mentha spicata)
Taxonomic identifieri34256 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesLamiaceaeNepetoideaeMentheaeMentha

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003895001 – 500Cytochrome P450 71D13Add BLAST500

Proteomic databases

PRIDEiQ9XHE7

Structurei

3D structure databases

ProteinModelPortaliQ9XHE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK15089

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XHE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELQISSAII ILVVTYTISL LIIKQWRKPK PQENLPPGPP KLPLIGHLHL
60 70 80 90 100
LWGKLPQHAL ASVAKQYGPV AHVQLGEVFS VVLSSREATK EAMKLVDPAC
110 120 130 140 150
ADRFESIGTK IMWYDNDDII FSPYSVHWRQ MRKICVSELL SARNVRSFGF
160 170 180 190 200
IRQDEVSRLL GHLRSSAAAG EAVDLTERIA TLTCSIICRA AFGSVIRDHE
210 220 230 240 250
ELVELVKDAL SMASGFELAD MFPSSKLLNL LCWNKSKLWR MRRRVDAILE
260 270 280 290 300
AIVEEHKLKK SGEFGGEDII DVLFRMQKDS QIKVPITTNA IKAFIFDTFS
310 320 330 340 350
AGTETSSTTT LWVMAELMRN PEVMAKAQAE VRAALKGKTD WDVDDVQELK
360 370 380 390 400
YMKSVVKETM RMHPPIPLIP RSCREECEVN GYTIPNKARI MINVWSMGRN
410 420 430 440 450
PLYWEKPETF WPERFDQVSR DFMGNDFEFI PFGAGRRICP GLNFGLANVE
460 470 480 490 500
VPLAQLLYHF DWKLAEGMNP SDMDMSEAEG LTGIRKNNLL LVPTPYDPSS
Length:500
Mass (Da):56,601
Last modified:November 1, 1999 - v1
Checksum:i402324F738F5949F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124816 mRNA Translation: AAD44151.1

Genome annotation databases

KEGGiag:AAD44151

Similar proteinsi

Entry informationi

Entry nameiC71DD_MENPI
AccessioniPrimary (citable) accession number: Q9XHE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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