Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chalcone synthase 1

Gene

CHS1

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1
Gene namesi
Name:CHS1
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeSorghinaeSorghum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Chalcone synthase 1PRO_0000216055Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ9XGX2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb05g020200.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XGX2.
SMRiQ9XGX2. Positions 7-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiENOG410IKG2. Eukaryota.
COG3424. LUCA.
HOGENOMiHOG000245460.
KOiK00660.
OMAiITAIIFR.
OrthoDBiEOG09360E8Q.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XGX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGATVTVEE VRKAQRATGP ATVLAIGTAT PANCVHQADY PDYYFRITKS
60 70 80 90 100
EHMTELKEKF KRMCDKSQIR KRYMHLTEEY LAENPNMCAY MAPSLDARQD
110 120 130 140 150
IVVVEVPKLG KAAAQKAIKE WGQPKSKITH LVFCTTSGVD MPGADYQLTK
160 170 180 190 200
MLGLRPSVNR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEITAV
210 220 230 240 250
TFRGPSESHL DSMVGQALFG DGAAAVIVGA DPDERVERPL FQLVSASQRI
260 270 280 290 300
LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIERALEEA FKPLGITDYN
310 320 330 340 350
SIFWVAHPGG PAILDQVEAK VGLEKERMRA TRHVLSEYGN MSSACVLFIL
360 370 380 390 400
DEMRKRSAED GQTTTGEGFD WGVLFGFGPG LTVETVVLHS VPITTGAAIT

A
Length:401
Mass (Da):43,745
Last modified:November 1, 1999 - v1
Checksum:i188D13F4F9126760
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152548 Genomic DNA. Translation: AAD41873.1.
RefSeqiXP_002450874.1. XM_002450829.1.
UniGeneiSbi.20314.

Genome annotation databases

EnsemblPlantsiSb05g020200.1; Sb05g020200.1; Sb05g020200.
GeneIDi8064817.
GrameneiSb05g020200.1; Sb05g020200.1; Sb05g020200.
KEGGisbi:SORBI_05g020200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152548 Genomic DNA. Translation: AAD41873.1.
RefSeqiXP_002450874.1. XM_002450829.1.
UniGeneiSbi.20314.

3D structure databases

ProteinModelPortaliQ9XGX2.
SMRiQ9XGX2. Positions 7-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4558.Sb05g020200.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSb05g020200.1; Sb05g020200.1; Sb05g020200.
GeneIDi8064817.
GrameneiSb05g020200.1; Sb05g020200.1; Sb05g020200.
KEGGisbi:SORBI_05g020200.

Phylogenomic databases

eggNOGiENOG410IKG2. Eukaryota.
COG3424. LUCA.
HOGENOMiHOG000245460.
KOiK00660.
OMAiITAIIFR.
OrthoDBiEOG09360E8Q.

Enzyme and pathway databases

UniPathwayiUPA00154.

Gene expression databases

ExpressionAtlasiQ9XGX2. baseline and differential.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHS1_SORBI
AccessioniPrimary (citable) accession number: Q9XGX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.