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Q9XGX2

- CHS1_SORBI

UniProt

Q9XGX2 - CHS1_SORBI

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Protein
Chalcone synthase 1
Gene
CHS1
Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681 By similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1
Gene namesi
Name:CHS1
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum

Organism-specific databases

GrameneiQ9XGX2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Chalcone synthase 1
PRO_0000216055Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb05g020200.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XGX2.
SMRiQ9XGX2. Positions 7-393.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3424.
HOGENOMiHOG000245460.
KOiK00660.
OMAiRICKQAC.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XGX2-1 [UniParc]FASTAAdd to Basket

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MAGATVTVEE VRKAQRATGP ATVLAIGTAT PANCVHQADY PDYYFRITKS    50
EHMTELKEKF KRMCDKSQIR KRYMHLTEEY LAENPNMCAY MAPSLDARQD 100
IVVVEVPKLG KAAAQKAIKE WGQPKSKITH LVFCTTSGVD MPGADYQLTK 150
MLGLRPSVNR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEITAV 200
TFRGPSESHL DSMVGQALFG DGAAAVIVGA DPDERVERPL FQLVSASQRI 250
LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIERALEEA FKPLGITDYN 300
SIFWVAHPGG PAILDQVEAK VGLEKERMRA TRHVLSEYGN MSSACVLFIL 350
DEMRKRSAED GQTTTGEGFD WGVLFGFGPG LTVETVVLHS VPITTGAAIT 400
A 401
Length:401
Mass (Da):43,745
Last modified:November 1, 1999 - v1
Checksum:i188D13F4F9126760
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152548 Genomic DNA. Translation: AAD41873.1.
RefSeqiXP_002450874.1. XM_002450829.1.
UniGeneiSbi.20314.

Genome annotation databases

GeneIDi8064817.
KEGGisbi:SORBI_05g020200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152548 Genomic DNA. Translation: AAD41873.1 .
RefSeqi XP_002450874.1. XM_002450829.1.
UniGenei Sbi.20314.

3D structure databases

ProteinModelPortali Q9XGX2.
SMRi Q9XGX2. Positions 7-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4558.Sb05g020200.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8064817.
KEGGi sbi:SORBI_05g020200.

Organism-specific databases

Gramenei Q9XGX2.

Phylogenomic databases

eggNOGi COG3424.
HOGENOMi HOG000245460.
KOi K00660.
OMAi RICKQAC.

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of chalcone synthase genes from sorghum."
    Lo S.-C.C., Nicholson R.L.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCHS1_SORBI
AccessioniPrimary (citable) accession number: Q9XGX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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