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Q9XGX2 (CHS1_SORBI) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chalcone synthase 1
EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 1
Gene names
Name:CHS1
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare)
Taxonomic identifier4558 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Sorghum

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 401401Chalcone synthase 1
PRO_0000216055

Sites

Active site1681 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XGX2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 188D13F4F9126760

FASTA40143,745
        10         20         30         40         50         60 
MAGATVTVEE VRKAQRATGP ATVLAIGTAT PANCVHQADY PDYYFRITKS EHMTELKEKF 

        70         80         90        100        110        120 
KRMCDKSQIR KRYMHLTEEY LAENPNMCAY MAPSLDARQD IVVVEVPKLG KAAAQKAIKE 

       130        140        150        160        170        180 
WGQPKSKITH LVFCTTSGVD MPGADYQLTK MLGLRPSVNR LMMYQQGCFA GGTVLRVAKD 

       190        200        210        220        230        240 
LAENNRGARV LVVCSEITAV TFRGPSESHL DSMVGQALFG DGAAAVIVGA DPDERVERPL 

       250        260        270        280        290        300 
FQLVSASQRI LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIERALEEA FKPLGITDYN 

       310        320        330        340        350        360 
SIFWVAHPGG PAILDQVEAK VGLEKERMRA TRHVLSEYGN MSSACVLFIL DEMRKRSAED 

       370        380        390        400 
GQTTTGEGFD WGVLFGFGPG LTVETVVLHS VPITTGAAIT A

« Hide

References

[1]"Molecular cloning of chalcone synthase genes from sorghum."
Lo S.-C.C., Nicholson R.L.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF152548 Genomic DNA. Translation: AAD41873.1.
RefSeqXP_002450874.1. XM_002450829.1.
UniGeneSbi.20314.

3D structure databases

ProteinModelPortalQ9XGX2.
SMRQ9XGX2. Positions 7-393.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8064817.
KEGGsbi:SORBI_05g020200.

Organism-specific databases

GrameneQ9XGX2.

Phylogenomic databases

eggNOGCOG3424.
HOGENOMHOG000245460.
KOK00660.
ProtClustDBPLN03170.

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS1_SORBI
AccessionPrimary (citable) accession number: Q9XGX2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: March 6, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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