Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chalcone synthase 7

Gene

CHS7

Organism
Sorghum bicolor (Sorghum) (Sorghum vulgare)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 7 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 7
Gene namesi
Name:CHS7
OrganismiSorghum bicolor (Sorghum) (Sorghum vulgare)
Taxonomic identifieri4558 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeSorghum

Organism-specific databases

GrameneiQ9XGX1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Chalcone synthase 7PRO_0000216061Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4558.Sb05g020220.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XGX1.
SMRiQ9XGX1. Positions 7-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiCOG3424.
HOGENOMiHOG000245460.
KOiK00660.
OMAiPETHEAM.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XGX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGATVTVEE VRKAQRATGP ATVLAIGTAT PANCVHQADY PDYYFRITKS
60 70 80 90 100
EHMTDLKEKF KRMCDKSQIR KRYMHLTEEY LAENPNMCAY MAPSLDARQD
110 120 130 140 150
IVVVEVPKLG KAAAQKAIKE WGQPKSKITH LVFCTTSGVD MPGADYQLTK
160 170 180 190 200
MLGLRPSVNR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEITAV
210 220 230 240 250
TFRGPSESHL DSMVGQALFG DGAAAVIVGA DPDKRVECPL FQLVSASQTI
260 270 280 290 300
LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIERSLEEA FKPLGITDYN
310 320 330 340 350
SIFWVAHPGG PAILDQVEAK VGLKKERMRA TRHVLSEYGN MSSACVLFIL
360 370 380 390 400
DEMRKRSAEE GQATTGEGFD WGVLFGFGPG LTVETVVLHS VPITIAAITA
Length:400
Mass (Da):43,576
Last modified:November 1, 1999 - v1
Checksum:i7A67C8D6ADA05CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152554 Genomic DNA. Translation: AAD41879.1.
RefSeqiXP_002450876.1. XM_002450831.1.
UniGeneiSbi.20237.

Genome annotation databases

GeneIDi8064819.
KEGGisbi:SORBI_05g020220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152554 Genomic DNA. Translation: AAD41879.1.
RefSeqiXP_002450876.1. XM_002450831.1.
UniGeneiSbi.20237.

3D structure databases

ProteinModelPortaliQ9XGX1.
SMRiQ9XGX1. Positions 7-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4558.Sb05g020220.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8064819.
KEGGisbi:SORBI_05g020220.

Organism-specific databases

GrameneiQ9XGX1.

Phylogenomic databases

eggNOGiCOG3424.
HOGENOMiHOG000245460.
KOiK00660.
OMAiPETHEAM.

Enzyme and pathway databases

UniPathwayiUPA00154.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of chalcone synthase genes from sorghum."
    Lo S.-C.C., Nicholson R.L.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. BTx623.

Entry informationi

Entry nameiCHS7_SORBI
AccessioniPrimary (citable) accession number: Q9XGX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.