Q9XGH7 (PP2A_TOBAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Serine/threonine-protein phosphatase PP2A catalytic subunit EC=3.1.3.16
Organism	Nicotiana tabacum (Common tobacco)
Taxonomic identifier	4097 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Serine/threonine-protein phosphatase PP2A catalytic subunit		PRO_0000058865
Sites
	Active site	121	1	Proton donor By similarity
	Metal binding	60	1	Iron By similarity
	Metal binding	62	1	Iron By similarity
	Metal binding	88	1	Iron By similarity
	Metal binding	88	1	Manganese By similarity
	Metal binding	120	1	Manganese By similarity
	Metal binding	170	1	Manganese By similarity
	Metal binding	244	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9XGH7 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: B24F1ABEC2793315	FASTA	312	35,639
	10 20 30 40 50 60 MDPVPSSASH GNLDEQIAQL MQCKPLSEQE VRGLCEKAKE ILMEESNVQP VKSPVTICGD 70 80 90 100 110 120 IHGQFHDLAE LFRIGGKCPD TNYLFMGDYV DRGYYSVETV TLLVALKVRY PQRITILRGN 130 140 150 160 170 180 HESRQITQVY GFYDECLRKY GNANVWKTFT DLFDYFPLTA LVESEIFCLH GGLSPSIETL 190 200 210 220 230 240 DNIRNFDRVQ EVPHEGAMCD LLWSDPDDRC GWGISPRGAG YTFGQDISEQ FNHTNNLKLI 250 260 270 280 290 300 ARAHQLVMEG FNWAHDQKVV TIFSAPNYCY RCGNMASILE VDDSRERTFI QFEPAPRRGE 310 PDVTRRTPDY FL

References

[1]	"Molecular analysis of protein phosphatase 2A in tobacco." Remus M., Stitt M., Zrenner R. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. SR1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ007496 mRNA. Translation: CAB46506.1.
3D structure databases
ProteinModelPortal	Q9XGH7.
SMR	Q9XGH7. Positions 13-312.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PP2A_TOBAC

Accession

Primary (citable) accession number: Q9XGH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	September 21, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program