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Protein

Serine/threonine-protein phosphatase PP2A catalytic subunit

Gene
N/A
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Manganese 1By similarity1
Metal bindingi62Manganese 1By similarity1
Metal bindingi88Manganese 1By similarity1
Metal bindingi88Manganese 2By similarity1
Metal bindingi120Manganese 2By similarity1
Active sitei121Proton donorBy similarity1
Metal bindingi170Manganese 2By similarity1
Metal bindingi244Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A catalytic subunit (EC:3.1.3.16)
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588651 – 312Serine/threonine-protein phosphatase PP2A catalytic subunitAdd BLAST312

Structurei

3D structure databases

ProteinModelPortaliQ9XGH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XGH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVPSSASH GNLDEQIAQL MQCKPLSEQE VRGLCEKAKE ILMEESNVQP
60 70 80 90 100
VKSPVTICGD IHGQFHDLAE LFRIGGKCPD TNYLFMGDYV DRGYYSVETV
110 120 130 140 150
TLLVALKVRY PQRITILRGN HESRQITQVY GFYDECLRKY GNANVWKTFT
160 170 180 190 200
DLFDYFPLTA LVESEIFCLH GGLSPSIETL DNIRNFDRVQ EVPHEGAMCD
210 220 230 240 250
LLWSDPDDRC GWGISPRGAG YTFGQDISEQ FNHTNNLKLI ARAHQLVMEG
260 270 280 290 300
FNWAHDQKVV TIFSAPNYCY RCGNMASILE VDDSRERTFI QFEPAPRRGE
310
PDVTRRTPDY FL
Length:312
Mass (Da):35,639
Last modified:November 1, 1999 - v1
Checksum:iB24F1ABEC2793315
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007496 mRNA. Translation: CAB46506.1.
RefSeqiNP_001312211.1. NM_001325282.1.
XP_016462375.1. XM_016606889.1.
UniGeneiNta.7128.

Genome annotation databases

GeneIDi107779504.
107785560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007496 mRNA. Translation: CAB46506.1.
RefSeqiNP_001312211.1. NM_001325282.1.
XP_016462375.1. XM_016606889.1.
UniGeneiNta.7128.

3D structure databases

ProteinModelPortaliQ9XGH7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107779504.
107785560.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP2A_TOBAC
AccessioniPrimary (citable) accession number: Q9XGH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.