Reviewed, UniProtKB/Swiss-Prot Q9XG98 (KPRS1_SPIOL)

Names and origin

Protein names

Recommended name:
    Ribose-phosphate pyrophosphokinase 1
    EC=2.7.6.1
Alternative name(s):
    Phosphoribosyl pyrophosphate synthetase 1

Gene names

Name:

PRS1

Organism

Spinacia oleracea (Spinach)

Taxonomic identifier

3562 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Amaranthaceae › Spinacia

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Ribose-phosphate pyrophosphokinase 1		PRO_0000141101
Regions
	Region	236 – 251	16	Binding of phosphoribosylpyrophosphate Potential
Sites
	Metal binding	150	1	Magnesium Potential
	Metal binding	152	1	Magnesium Potential
	Metal binding	161	1	Magnesium Potential
	Metal binding	165	1	Magnesium Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9XG98-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: BD797280922B5347	FASTA	336	36,606
	10 20 30 40 50 60 MDQQSFPSFM ASTHFDSSIN RNDTRLRIFS GTANPALAQE IACYMGLQLG KIKIKRFADG 70 80 90 100 110 120 EIYVQLQESV RGCDVFLVQP TCPPANENLM ELLIMIDACR RASAKNITAV IPYFGYARAD 130 140 150 160 170 180 RKTQGRESIA AKLVANLITE AGANRVLACD LHSGQSMGYF DIPVDHVYGQ PVILDYLASK 190 200 210 220 230 240 TICSDDLVVV SPDVGGVARA RAFAKKLSDA PLAIVDKRRH GHNVAEVMNL IGDVKGKVAV 250 260 270 280 290 300 MVDDMIDTAG TISKGAALLH QEGAREVYAC STHAVFSPPA IERLSSGLFQ EVIITNTIPV 310 320 330 LEKNYFPQLT VLSVANLLGE TIWRVHDDCS VSSIFQ

References

[1]	"Organellar and cytosolic localization of four phosphoribosyl diphosphate synthase isozymes in spinach." Krath B.N., Hove-Jensen B. Plant Physiol. 119:497-506(1999) [PubMed: 9952445] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leaf.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ006940 mRNA. Translation: CAB43599.1.
3D structure databases
HSSP	HSSP built from PDB template 1DKR based on UniProtKB P14193.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.6.1. 286.
Family and domain databases
InterPro	IPR000842. PRib-PP_synthetase_CS. IPR000836. PRibTrfase. IPR005946. PRPP_kinase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01251. ribP_PPkin. 1 hit.
PROSITE	PS00114. PRPP_SYNTHETASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPRS1_SPIOL

Accession

Primary (citable) accession number: Q9XG98

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	November 1, 1999
Last modified:	September 22, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)