UniProtKB - Q9XG81 (PLA22_ORYSJ)
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Protein
Probable phospholipase A2 homolog 2
Gene
PLA2-II
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli.By similarity
Catalytic activityi
Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation
Cofactori
Ca2+Note: Binds 1 Ca2+ ion per subunit.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 62 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 64 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 67 | Calcium; via carbonyl oxygen | 1 | |
Active sitei | 86 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 87 | Calcium | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- lipid binding Source: UniProtKB
- phospholipase A2 activity Source: UniProtKB-EC
- phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) Source: UniProtKB-EC
- phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) Source: UniProtKB-EC
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: UniProtKB-KW
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.1.4. 4460. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PLA2-II Ordered Locus Names:Os03g0261100, LOC_Os03g15460 ORF Names:OsJ_10213 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5000065168 | 26 – 153 | Probable phospholipase A2 homolog 2Add BLAST | 128 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 70 | 1 Publication | ||
Disulfide bondi | 46 ↔ 76 | 1 Publication | ||
Disulfide bondi | 51 ↔ 123 | 1 Publication | ||
Disulfide bondi | 63 ↔ 83 | 1 Publication | ||
Disulfide bondi | 82 ↔ 109 | 1 Publication | ||
Disulfide bondi | 89 ↔ 102 | 1 Publication |
Keywords - PTMi
Disulfide bondExpressioni
Gene expression databases
ExpressionAtlasi | Q9XG81. baseline and differential. |
Genevisiblei | Q9XG81. OS. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 28 – 30 | Combined sources | 3 | |
Beta strandi | 39 – 41 | Combined sources | 3 | |
Beta strandi | 47 – 50 | Combined sources | 4 | |
Turni | 54 – 56 | Combined sources | 3 | |
Beta strandi | 58 – 60 | Combined sources | 3 | |
Helixi | 78 – 91 | Combined sources | 14 | |
Turni | 92 – 95 | Combined sources | 4 | |
Helixi | 100 – 110 | Combined sources | 11 | |
Helixi | 125 – 149 | Combined sources | 25 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WG7 | X-ray | 2.00 | A/B | 25-153 | [»] | |
2WG8 | X-ray | 2.30 | A/B/C | 26-153 | [»] | |
2WG9 | X-ray | 2.00 | A/B | 25-153 | [»] | |
SMRi | Q9XG81. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9XG81. |
Family & Domainsi
Sequence similaritiesi
Belongs to the phospholipase A2 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
InParanoidi | Q9XG81. |
OMAi | RTCESKY. |
OrthoDBi | EOG09360R76. |
Family and domain databases
Gene3Di | 1.20.90.10. 1 hit. |
InterProi | View protein in InterPro IPR001211. PLipase_A2. IPR036444. PLipase_A2_dom_sf. IPR033113. PLipase_A2_His_AS. |
PANTHERi | PTHR11716. PTHR11716. 1 hit. |
SUPFAMi | SSF48619. SSF48619. 1 hit. |
PROSITEi | View protein in PROSITE PS00118. PA2_HIS. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9XG81-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFFLKLAPR CSVLLLLLLV TASRGLNIGD LLGSTPAKDQ GCSRTCESQF
60 70 80 90 100
CTIAPLLRYG KYCGILYSGC PGERPCDALD ACCMVHDHCV DTHNDDYLNT
110 120 130 140 150
MCNENLLSCI DRVSGATFPG NKCNVGQTAS VIRGVIETAV FAGKILHKRD
DGQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ238117 mRNA. Translation: CAB40842.1. AP008209 Genomic DNA. Translation: BAF11534.1. AP014959 Genomic DNA. Translation: BAS83356.1. CM000140 Genomic DNA. Translation: EEE58732.1. |
RefSeqi | XP_015629036.1. XM_015773550.1. |
UniGenei | Os.4604. |
Genome annotation databases
EnsemblPlantsi | Os03t0261100-01; Os03t0261100-01; Os03g0261100. |
GeneIDi | 4332319. |
Gramenei | Os03t0261100-01; Os03t0261100-01; Os03g0261100. |
KEGGi | osa:4332319. |
Similar proteinsi
Entry informationi
Entry namei | PLA22_ORYSJ | |
Accessioni | Q9XG81Primary (citable) accession number: Q9XG81 Secondary accession number(s): A0A0P0VVN9, Q0DTA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 3, 2009 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 28, 2018 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |