PLA2-II

Functionⁱ

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli.By similarity

Catalytic activityⁱ

Phosphatidylcholine + H₂O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactorⁱ

Ca²⁺Note: Binds 1 Ca²⁺ ion per subunit.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	62	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	64	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	67	Calcium; via carbonyl oxygen	1
Active siteⁱ	86	PROSITE-ProRule annotation	1
Metal bindingⁱ	87	Calcium	1

GO - Molecular functionⁱ

calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19457861
lipid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19457861
phospholipase A2 activity Source: UniProtKB-EC
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) Source: UniProtKB-EC
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arachidonic acid secretion Source: InterPro
lipid catabolic process Source: UniProtKB-KW
phospholipid metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Lipid degradation, Lipid metabolism
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	3.1.1.4. 4460.

BRENDAⁱ

3.1.1.4. 4460.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable phospholipase A2 homolog 2 (EC:3.1.1.4)
Gene namesⁱ	Name:PLA2-II Ordered Locus Names:Os03g0261100, LOC_Os03g15460 ORF Names:OsJ_10213
Organismⁱ	Oryza sativa subsp. japonica (Rice)
Taxonomic identifierⁱ	39947 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
Proteomesⁱ	UP000059680 Componentⁱ: Chromosome 3

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_5000065168	26 – 153	Probable phospholipase A2 homolog 2Add BLAST		128

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	42 ↔ 70	1 Publication
Disulfide bondⁱ	46 ↔ 76	1 Publication
Disulfide bondⁱ	51 ↔ 123	1 Publication
Disulfide bondⁱ	63 ↔ 83	1 Publication
Disulfide bondⁱ	82 ↔ 109	1 Publication
Disulfide bondⁱ	89 ↔ 102	1 Publication

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q9XG81. baseline and differential.
Genevisibleⁱ	Q9XG81. OS.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	28 – 30	Combined sources	3
Beta strandⁱ	39 – 41	Combined sources	3
Beta strandⁱ	47 – 50	Combined sources	4
Turnⁱ	54 – 56	Combined sources	3
Beta strandⁱ	58 – 60	Combined sources	3
Helixⁱ	78 – 91	Combined sources	14
Turnⁱ	92 – 95	Combined sources	4
Helixⁱ	100 – 110	Combined sources	11
Helixⁱ	125 – 149	Combined sources	25

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2WG7	X-ray	2.00	A/B	25-153	[»]
	2WG8	X-ray	2.30	A/B/C	26-153	[»]
	2WG9	X-ray	2.00	A/B	25-153	[»]
SMRⁱ	Q9XG81.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9XG81.

EvolutionaryTraceⁱ

Q9XG81.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the phospholipase A2 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

InParanoidⁱ	Q9XG81.
OMAⁱ	RTCESKY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360R76.

Family and domain databases

Gene3Dⁱ	1.20.90.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001211. PLipase_A2. IPR036444. PLipase_A2_dom_sf. IPR033113. PLipase_A2_His_AS.
PANTHERⁱ	PTHR11716. PTHR11716. 1 hit.
SUPFAMⁱ	SSF48619. SSF48619. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00118. PA2_HIS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9XG81-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRFFLKLAPR CSVLLLLLLV TASRGLNIGD LLGSTPAKDQ GCSRTCESQF 
        60         70         80         90        100
CTIAPLLRYG KYCGILYSGC PGERPCDALD ACCMVHDHCV DTHNDDYLNT 
       110        120        130        140        150
MCNENLLSCI DRVSGATFPG NKCNVGQTAS VIRGVIETAV FAGKILHKRD 

DGQ

Length:153

Mass (Da):16,578

Last modified:November 1, 1999 - v1

Checksum:ⁱC9AC0BDB1F2885F6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ238117 mRNA. Translation: CAB40842.1. AP008209 Genomic DNA. Translation: BAF11534.1. AP014959 Genomic DNA. Translation: BAS83356.1. CM000140 Genomic DNA. Translation: EEE58732.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015629036.1. XM_015773550.1.
UniGeneⁱ	Os.4604.

Genome annotation databases

EnsemblPlantsⁱ	Os03t0261100-01; Os03t0261100-01; Os03g0261100.
GeneIDⁱ	4332319.
Grameneⁱ	Os03t0261100-01; Os03t0261100-01; Os03g0261100.
KEGGⁱ	osa:4332319.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9XG81	A0A0D9VS56 UPI0001A57B5A UPI0001A57B5C UPI0001A57B5B	Leersia perrieri Oryza sativa (Rice)	153	UniRef90_Q9XG81	Cluster: Probable phospholipase A2 homolog 2	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9XG81	A0A0D9VS56 UPI0001A57B5A UPI0001A57B5C UPI0001A57B5B A0A1E5UY15 K4AGM7 M0YN77 I1H787 A0A287PAJ0	Leersia perrieri Oryza sativa (Rice) Dichanthelium oligosanthes Setaria italica (Foxtail millet) (Panicum italicum) Hordeum vulgare subsp. vulgare (Domesticated barley) Brachypodium distachyon (Purple false brome) (Trachynia distachya)	153	UniRef50_Q9XG81	Cluster: Probable phospholipase A2 homolog 2	10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ238117 mRNA. Translation: CAB40842.1. AP008209 Genomic DNA. Translation: BAF11534.1. AP014959 Genomic DNA. Translation: BAS83356.1. CM000140 Genomic DNA. Translation: EEE58732.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_015629036.1. XM_015773550.1.
UniGeneⁱ	Os.4604.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2WG7	X-ray	2.00	A/B	25-153	[»]
	2WG8	X-ray	2.30	A/B/C	26-153	[»]
	2WG9	X-ray	2.00	A/B	25-153	[»]
SMRⁱ	Q9XG81.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	Os03t0261100-01; Os03t0261100-01; Os03g0261100.
GeneIDⁱ	4332319.
Grameneⁱ	Os03t0261100-01; Os03t0261100-01; Os03g0261100.
KEGGⁱ	osa:4332319.

Phylogenomic databases

InParanoidⁱ	Q9XG81.
OMAⁱ	RTCESKY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360R76.

Enzyme and pathway databases

BRENDAⁱ	3.1.1.4. 4460.

BRENDAⁱ

3.1.1.4. 4460.

Miscellaneous databases

EvolutionaryTraceⁱ	Q9XG81.

EvolutionaryTraceⁱ

Q9XG81.

Gene expression databases

ExpressionAtlasⁱ	Q9XG81. baseline and differential.
Genevisibleⁱ	Q9XG81. OS.

Family and domain databases

Gene3Dⁱ	1.20.90.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001211. PLipase_A2. IPR036444. PLipase_A2_dom_sf. IPR033113. PLipase_A2_His_AS.
PANTHERⁱ	PTHR11716. PTHR11716. 1 hit.
SUPFAMⁱ	SSF48619. SSF48619. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00118. PA2_HIS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLA22_ORYSJ
Accessionⁱ	Q9XG81Primary (citable) accession number: Q9XG81 Secondary accession number(s): A0A0P0VVN9, Q0DTA4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
	Last sequence update:	November 1, 1999
	Last modified:	February 28, 2018
	This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9XG81 (PLA22_ORYSJ)

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Probable phospholipase A2 homolog 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ