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Protein

Probable phospholipase A2 homolog 2

Gene

PLA2-II

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli.By similarity

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Calcium; via carbonyl oxygen
Metal bindingi64 – 641Calcium; via carbonyl oxygen
Metal bindingi67 – 671Calcium; via carbonyl oxygen
Active sitei86 – 861PROSITE-ProRule annotation
Metal bindingi87 – 871Calcium

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • lipid binding Source: UniProtKB
  • phospholipase A2 activity Source: UniProtKB-EC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.4. 4460.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipase A2 homolog 2 (EC:3.1.1.4)
Gene namesi
Name:PLA2-II
Ordered Locus Names:Os03g0261100, LOC_Os03g15460
ORF Names:OsJ_10213
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 153128Probable phospholipase A2 homolog 2PRO_5000065168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 701 Publication
Disulfide bondi46 ↔ 761 Publication
Disulfide bondi51 ↔ 1231 Publication
Disulfide bondi63 ↔ 831 Publication
Disulfide bondi82 ↔ 1091 Publication
Disulfide bondi89 ↔ 1021 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

ExpressionAtlasiQ9XG81. baseline and differential.
GenevisibleiQ9XG81. OS.

Structurei

Secondary structure

1
153
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 303Combined sources
Beta strandi39 – 413Combined sources
Beta strandi47 – 504Combined sources
Turni54 – 563Combined sources
Beta strandi58 – 603Combined sources
Helixi78 – 9114Combined sources
Turni92 – 954Combined sources
Helixi100 – 11011Combined sources
Helixi125 – 14925Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WG7X-ray2.00A/B25-153[»]
2WG8X-ray2.30A/B/C26-153[»]
2WG9X-ray2.00A/B25-153[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9XG81.

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ9XG81.
OMAiVHDHCVD.
OrthoDBiEOG09360R76.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00118. PA2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XG81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFFLKLAPR CSVLLLLLLV TASRGLNIGD LLGSTPAKDQ GCSRTCESQF
60 70 80 90 100
CTIAPLLRYG KYCGILYSGC PGERPCDALD ACCMVHDHCV DTHNDDYLNT
110 120 130 140 150
MCNENLLSCI DRVSGATFPG NKCNVGQTAS VIRGVIETAV FAGKILHKRD

DGQ
Length:153
Mass (Da):16,578
Last modified:November 1, 1999 - v1
Checksum:iC9AC0BDB1F2885F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238117 mRNA. Translation: CAB40842.1.
AP008209 Genomic DNA. Translation: BAF11534.1.
AP014959 Genomic DNA. Translation: BAS83356.1.
CM000140 Genomic DNA. Translation: EEE58732.1.
RefSeqiXP_015629036.1. XM_015773550.1.
UniGeneiOs.4604.

Genome annotation databases

EnsemblPlantsiOS03T0261100-01; OS03T0261100-01; OS03G0261100.
GeneIDi4332319.
GrameneiOS03T0261100-01; OS03T0261100-01; OS03G0261100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238117 mRNA. Translation: CAB40842.1.
AP008209 Genomic DNA. Translation: BAF11534.1.
AP014959 Genomic DNA. Translation: BAS83356.1.
CM000140 Genomic DNA. Translation: EEE58732.1.
RefSeqiXP_015629036.1. XM_015773550.1.
UniGeneiOs.4604.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WG7X-ray2.00A/B25-153[»]
2WG8X-ray2.30A/B/C26-153[»]
2WG9X-ray2.00A/B25-153[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS03T0261100-01; OS03T0261100-01; OS03G0261100.
GeneIDi4332319.
GrameneiOS03T0261100-01; OS03T0261100-01; OS03G0261100.

Phylogenomic databases

InParanoidiQ9XG81.
OMAiVHDHCVD.
OrthoDBiEOG09360R76.

Enzyme and pathway databases

BRENDAi3.1.1.4. 4460.

Miscellaneous databases

EvolutionaryTraceiQ9XG81.

Gene expression databases

ExpressionAtlasiQ9XG81. baseline and differential.
GenevisibleiQ9XG81. OS.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00118. PA2_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLA22_ORYSJ
AccessioniPrimary (citable) accession number: Q9XG81
Secondary accession number(s): A0A0P0VVN9, Q0DTA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.