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Q9XG77 (PSA6_TOBAC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-6

EC=3.4.25.1
Alternative name(s):
20S proteasome alpha subunit A
20S proteasome subunit alpha-1
Gene names
Name:PAA1
Synonyms:PSA1
OrganismNicotiana tabacum (Common tobacco)
Taxonomic identifier4097 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Proteasome subunit alpha type-6
PRO_0000124139

Sequences

Sequence LengthMass (Da)Tools
Q9XG77 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 7152CE4FC6155A64

FASTA24627,303
        10         20         30         40         50         60 
MSRGSGGGYD RHITIFSPEG RLFQVEYAFK AVKAAGITSI GVRGKDSVCV VTQKKVPDKL 

        70         80         90        100        110        120 
LDQTSVSHLF PITKYLGLLA TGMTADARTL VQQARNEAAE FRFKYGYEMP VDVLSKWIAD 

       130        140        150        160        170        180 
KSQVYTQHAY MRPLGVVAMI LGIDEEKGPQ LFKCDPAGHF FGHKATSAGS KEQEAINFLE 

       190        200        210        220        230        240 
KKMKNDPAFS YEETVQTAIS ALQSVLQEDF KASEIEVGVV KKEDPIFRVL TTEEIDEHLT 


AISERD 

« Hide

References

[1]"Expression of a proteasome alpha-type subunit gene during tobacco development and senescence."
Bahrami A.R., Gray J.E.
Plant Mol. Biol. 39:325-333(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Wisconsin 38.
Tissue: Style.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y16644 mRNA. Translation: CAB39975.1.

3D structure databases

ProteinModelPortalQ9XG77.
SMRQ9XG77. Positions 2-245.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPST01.971.

Proteomic databases

PRIDEQ9XG77.
ProMEXQ9XG77.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA6_TOBAC
AccessionPrimary (citable) accession number: Q9XG77
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries