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Q9XG77

- PSA6_TOBAC

UniProt

Q9XG77 - PSA6_TOBAC

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Protein

Proteasome subunit alpha type-6

Gene
PAA1, PSA1
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-6 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit A
20S proteasome subunit alpha-1
Gene namesi
Name:PAA1
Synonyms:PSA1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Proteasome subunit alpha type-6PRO_0000124139Add
BLAST

Proteomic databases

PRIDEiQ9XG77.
ProMEXiQ9XG77.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9XG77.
SMRiQ9XG77. Positions 2-245.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XG77-1 [UniParc]FASTAAdd to Basket

« Hide

MSRGSGGGYD RHITIFSPEG RLFQVEYAFK AVKAAGITSI GVRGKDSVCV    50
VTQKKVPDKL LDQTSVSHLF PITKYLGLLA TGMTADARTL VQQARNEAAE 100
FRFKYGYEMP VDVLSKWIAD KSQVYTQHAY MRPLGVVAMI LGIDEEKGPQ 150
LFKCDPAGHF FGHKATSAGS KEQEAINFLE KKMKNDPAFS YEETVQTAIS 200
ALQSVLQEDF KASEIEVGVV KKEDPIFRVL TTEEIDEHLT AISERD 246
Length:246
Mass (Da):27,303
Last modified:November 1, 1999 - v1
Checksum:i7152CE4FC6155A64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16644 mRNA. Translation: CAB39975.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16644 mRNA. Translation: CAB39975.1 .

3D structure databases

ProteinModelPortali Q9XG77.
SMRi Q9XG77. Positions 2-245.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.971.

Proteomic databases

PRIDEi Q9XG77.
ProMEXi Q9XG77.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of a proteasome alpha-type subunit gene during tobacco development and senescence."
    Bahrami A.R., Gray J.E.
    Plant Mol. Biol. 39:325-333(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Wisconsin 38.
    Tissue: Style.

Entry informationi

Entry nameiPSA6_TOBAC
AccessioniPrimary (citable) accession number: Q9XG77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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