Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9XF42

- PROF3_MALDO

UniProt

Q9XF42 - PROF3_MALDO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Profilin-3

Gene
N/A
Organism
Malus domestica (Apple) (Pyrus malus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-3
Alternative name(s):
GD4-5
Pollen allergen Mal d 4.0101
Allergen: Mal d 4.0101
OrganismiMalus domestica (Apple) (Pyrus malus)
Taxonomic identifieri3750 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaeMalus

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei2414. Mal d 4.0101.
796. Mal d 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 131130Profilin-3PRO_0000199653Add
BLAST

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Structurei

3D structure databases

ProteinModelPortaliQ9XF42.
SMRiQ9XF42. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XF42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWQAYVDDH LMCDIDGNRL TAAAILGQDG SVWSQSASFP AFKPEEIAAI
60 70 80 90 100
LKDFDQPGTL APTGLFLGGT KYMVIQGEPG AVIRGKKGSG GITIKKTSQA
110 120 130
LLIGIYDEPV TPGQCNIVVE RLGDYLIEQG L
Length:131
Mass (Da):13,957
Last modified:November 1, 1999 - v1
Checksum:iD947E586A0325F2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129428 mRNA. Translation: AAD29414.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129428 mRNA. Translation: AAD29414.1 .

3D structure databases

ProteinModelPortali Q9XF42.
SMRi Q9XF42. Positions 2-131.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 2414. Mal d 4.0101.
796. Mal d 4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view ]
PANTHERi PTHR11604. PTHR11604. 1 hit.
Pfami PF00235. Profilin. 1 hit.
[Graphical view ]
PRINTSi PR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTi SM00392. PROF. 1 hit.
[Graphical view ]
SUPFAMi SSF55770. SSF55770. 1 hit.
PROSITEi PS00414. PROFILIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of profilin from apple as the allergen Mal d 4."
    Scheurer S., Wangorsch A., Haustein D., Vieths S.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Golden Delicious.

Entry informationi

Entry nameiPROF3_MALDO
AccessioniPrimary (citable) accession number: Q9XF42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3