Q9XF42 (PROF3_MALDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Profilin-3 Alternative name(s): GD4-5 Pollen allergen Mal d 4.0101 Allergen=Mal d 4.0101
Organism	Malus domestica (Apple) (Pyrus malus)
Taxonomic identifier	3750 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Rosales › Rosaceae › Amygdaloideae › Maleae › Malus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Disease	Allergen
Ligand	Actin-binding
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 131	130	Profilin-3		PRO_0000199653

Sequences

	Sequence		Length	Mass (Da)
	Q9XF42 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: D947E586A0325F2A	FASTA	131	13,957
	10 20 30 40 50 60 MSWQAYVDDH LMCDIDGNRL TAAAILGQDG SVWSQSASFP AFKPEEIAAI LKDFDQPGTL 70 80 90 100 110 120 APTGLFLGGT KYMVIQGEPG AVIRGKKGSG GITIKKTSQA LLIGIYDEPV TPGQCNIVVE 130 RLGDYLIEQG L

References

[1]	"Characterization of profilin from apple as the allergen Mal d 4." Scheurer S., Wangorsch A., Haustein D., Vieths S. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Golden Delicious.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF129428 mRNA. Translation: AAD29414.1.
3D structure databases
ProteinModelPortal	Q9XF42.
SMR	Q9XF42. Positions 2-131.
ModBase	Search...
Protein family/group databases
Allergome	2414. Mal d 4.0101. 796. Mal d 4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR027310. Profilin_CS. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
PANTHER	PTHR11604. PTHR11604. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF3_MALDO

Accession

Primary (citable) accession number: Q9XF42

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program