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Protein

Profilin

Gene
N/A
Organism
Pyrus communis (Pear) (Pyrus domestica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin
Alternative name(s):
Allergen Pyr c 3
Allergen: Pyr c 4
OrganismiPyrus communis (Pear) (Pyrus domestica)
Taxonomic identifieri23211 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaePyrus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Food allergen.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3459. Pyr c 4.0101.
608. Pyr c 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001996702 – 131ProfilinAdd BLAST130

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9XF38.
SMRiQ9XF38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiView protein in InterPro
IPR005455. PFN.
IPR036140. PFN_sf.
IPR027310. Profilin_CS.
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiView protein in Pfam
PF00235. Profilin. 1 hit.
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiView protein in SMART
SM00392. PROF. 1 hit.
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiView protein in PROSITE
PS00414. PROFILIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XF38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQAYVDDH LMCDIDGHHL TAAAILGHDG SVWAQSSTFP KFKPEEITAI
60 70 80 90 100
MKDFDEPGSL APTGLHLGGT KYMVIQGEGG AVIRGKKGSG GVTVKKTSQA
110 120 130
LVFGIYEEPL TPGQCNMIVE RLGDYLIDQG L
Length:131
Mass (Da):14,064
Last modified:November 1, 1999 - v1
Checksum:iB51211E2DB6C0938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129424 mRNA. Translation: AAD29410.1.

Similar proteinsi

Entry informationi

Entry nameiPROF_PYRCO
AccessioniPrimary (citable) accession number: Q9XF38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families