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Q9XF38 (PROF_PYRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Profilin
Alternative name(s):
Allergen Pyr c 3
Allergen=Pyr c 4
OrganismPyrus communis (Pear) (Pyrus domestica)
Taxonomic identifier23211 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaePyrus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.

Subunit structure

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Allergenic properties

Causes an allergic reaction in human. Food allergen. Ref.1

Sequence similarities

Belongs to the profilin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DiseaseAllergen
   LigandActin-binding
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 131130Profilin
PRO_0000199670

Sequences

Sequence LengthMass (Da)Tools
Q9XF38 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B51211E2DB6C0938

FASTA13114,064
        10         20         30         40         50         60 
MSWQAYVDDH LMCDIDGHHL TAAAILGHDG SVWAQSSTFP KFKPEEITAI MKDFDEPGSL 

        70         80         90        100        110        120 
APTGLHLGGT KYMVIQGEGG AVIRGKKGSG GVTVKKTSQA LVFGIYEEPL TPGQCNMIVE 

       130 
RLGDYLIDQG L 

« Hide

References

[1]"Cross-reactivity within the profilin panallergen family investigated by comparison of recombinant profilins from pear (Pyr c 4), cherry (Pru av 4) and celery (Api g 4) with birch pollen profilin Bet v 2."
Scheurer S., Wangorsch A., Nerkamp J., Skov P.S., Ballmer-Weber B., Wuthrich B., Haustein D., Vieths S.
J. Chromatogr. B 756:315-325(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
Strain: cv. Williams.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF129424 mRNA. Translation: AAD29410.1.

3D structure databases

ProteinModelPortalQ9XF38.
SMRQ9XF38. Positions 2-131.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3459. Pyr c 4.0101.
608. Pyr c 4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PANTHERPTHR11604. PTHR11604. 1 hit.
PfamPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMSSF55770. SSF55770. 1 hit.
PROSITEPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROF_PYRCO
AccessionPrimary (citable) accession number: Q9XF38
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries