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Q9XF38

- PROF_PYRCO

UniProt

Q9XF38 - PROF_PYRCO

Protein

Profilin

Gene
N/A
Organism
Pyrus communis (Pear) (Pyrus domestica)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.By similarity

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Profilin
    Alternative name(s):
    Allergen Pyr c 3
    Allergen: Pyr c 4
    OrganismiPyrus communis (Pear) (Pyrus domestica)
    Taxonomic identifieri23211 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaePyrus

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Food allergen.1 Publication

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3459. Pyr c 4.0101.
    608. Pyr c 4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 131130ProfilinPRO_0000199670Add
    BLAST

    Interactioni

    Subunit structurei

    Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XF38.
    SMRiQ9XF38. Positions 2-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the profilin family.Curated

    Family and domain databases

    InterProiIPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view]
    PANTHERiPTHR11604. PTHR11604. 1 hit.
    PfamiPF00235. Profilin. 1 hit.
    [Graphical view]
    PRINTSiPR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTiSM00392. PROF. 1 hit.
    [Graphical view]
    SUPFAMiSSF55770. SSF55770. 1 hit.
    PROSITEiPS00414. PROFILIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XF38-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWQAYVDDH LMCDIDGHHL TAAAILGHDG SVWAQSSTFP KFKPEEITAI    50
    MKDFDEPGSL APTGLHLGGT KYMVIQGEGG AVIRGKKGSG GVTVKKTSQA 100
    LVFGIYEEPL TPGQCNMIVE RLGDYLIDQG L 131
    Length:131
    Mass (Da):14,064
    Last modified:November 1, 1999 - v1
    Checksum:iB51211E2DB6C0938
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129424 mRNA. Translation: AAD29410.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129424 mRNA. Translation: AAD29410.1 .

    3D structure databases

    ProteinModelPortali Q9XF38.
    SMRi Q9XF38. Positions 2-131.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3459. Pyr c 4.0101.
    608. Pyr c 4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view ]
    PANTHERi PTHR11604. PTHR11604. 1 hit.
    Pfami PF00235. Profilin. 1 hit.
    [Graphical view ]
    PRINTSi PR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTi SM00392. PROF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55770. SSF55770. 1 hit.
    PROSITEi PS00414. PROFILIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-reactivity within the profilin panallergen family investigated by comparison of recombinant profilins from pear (Pyr c 4), cherry (Pru av 4) and celery (Api g 4) with birch pollen profilin Bet v 2."
      Scheurer S., Wangorsch A., Nerkamp J., Skov P.S., Ballmer-Weber B., Wuthrich B., Haustein D., Vieths S.
      J. Chromatogr. B 756:315-325(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
      Strain: cv. Williams.

    Entry informationi

    Entry nameiPROF_PYRCO
    AccessioniPrimary (citable) accession number: Q9XF38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3