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Protein

Annexin D2

Gene

ANN2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May mediate regulated, targeted secretion of Golgi-derived vesicles during seedling development.

GO - Molecular functioni

GO - Biological processi

  • polysaccharide transport Source: TAIR
  • response to cold Source: TAIR
  • response to heat Source: TAIR
  • response to salt stress Source: TAIR
  • response to water deprivation Source: TAIR
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-ATH-114608. Platelet degranulation.
R-ATH-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin D2
Alternative name(s):
AnnAt2
Gene namesi
Name:ANN2
Synonyms:ANNAT2
Ordered Locus Names:At5g65020
ORF Names:MXK3.27
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G65020.

Subcellular locationi

GO - Cellular componenti

  • apoplast Source: TAIR
  • cytosol Source: TAIR
  • membrane Source: UniProtKB-SubCell
  • nucleus Source: TAIR
  • thylakoid Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002788162 – 317Annexin D2Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9XEE2.
PRIDEiQ9XEE2.

PTM databases

iPTMnetiQ9XEE2.

Expressioni

Tissue specificityi

Expressed mainly in roots and flowers. Low in stems and bearly detectable in leaves.1 Publication

Developmental stagei

In germinating seedlings, expressed in root, hypocotyl and cotyledon epidermal cells. By day 4, expression expands in the root endodermis and throughout initiating lateral roots. As the seedling matures, expression in the hypocotyl and cotyledons decreases and by day 14, expression is restricted to creases between the shoot meristem and its lateral primordia.1 Publication

Inductioni

Up-regulated by heat shock stress. Down-regulated by cold, dehydration, and salt stresses.1 Publication

Gene expression databases

ExpressionAtlasiQ9XEE2. baseline and differential.
GenevisibleiQ9XEE2. AT.

Interactioni

Protein-protein interaction databases

BioGridi21868. 2 interactors.
IntActiQ9XEE2. 1 interactor.
STRINGi3702.AT5G65020.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XEE2.
SMRiQ9XEE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 80Annexin 1Add BLAST66
Repeati87 – 152Annexin 2Add BLAST66
Repeati170 – 236Annexin 3Add BLAST67
Repeati246 – 311Annexin 4Add BLAST66

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158802.
InParanoidiQ9XEE2.
OMAiHYNDAFG.
OrthoDBiEOG09360FWC.
PhylomeDBiQ9XEE2.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR009118. Annexin_pln.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01814. ANNEXINPLANT.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9XEE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLKVPSNV PLPEDDAEQL HKAFSGWGTN EKLIISILAH RNAAQRSLIR
60 70 80 90 100
SVYAATYNED LLKALDKELS SDFERAVMLW TLDPPERDAY LAKESTKMFT
110 120 130 140 150
KNNWVLVEIA CTRPALELIK VKQAYQARYK KSIEEDVAQH TSGDLRKLLL
160 170 180 190 200
PLVSTFRYEG DDVNMMLARS EAKILHEKVS EKSYSDDDFI RILTTRSKAQ
210 220 230 240 250
LGATLNHYNN EYGNAINKNL KEESDDNDYM KLLRAVITCL TYPEKHFEKV
260 270 280 290 300
LRLSINKMGT DEWGLTRVVT TRTEVDMERI KEEYQRRNSI PLDRAIAKDT
310
SGDYEDMLVA LLGHGDA
Length:317
Mass (Da):36,266
Last modified:November 1, 1999 - v1
Checksum:i8A643FA4BFE780E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118 – 122LIKVK → FIQG in CAA81121 (PubMed:8281187).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083914 mRNA. Translation: AAD34237.1.
AB019236 Genomic DNA. Translation: BAA97314.1.
CP002688 Genomic DNA. Translation: AED97986.1.
AY070400 mRNA. Translation: AAL49896.1.
AY096577 mRNA. Translation: AAM20227.1.
AY085713 mRNA. Translation: AAM62931.1.
Z25968 mRNA. Translation: CAA81121.1.
RefSeqiNP_201307.1. NM_125901.4. [Q9XEE2-1]
UniGeneiAt.20837.

Genome annotation databases

EnsemblPlantsiAT5G65020.1; AT5G65020.1; AT5G65020. [Q9XEE2-1]
GeneIDi836626.
GrameneiAT5G65020.1; AT5G65020.1; AT5G65020.
KEGGiath:AT5G65020.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083914 mRNA. Translation: AAD34237.1.
AB019236 Genomic DNA. Translation: BAA97314.1.
CP002688 Genomic DNA. Translation: AED97986.1.
AY070400 mRNA. Translation: AAL49896.1.
AY096577 mRNA. Translation: AAM20227.1.
AY085713 mRNA. Translation: AAM62931.1.
Z25968 mRNA. Translation: CAA81121.1.
RefSeqiNP_201307.1. NM_125901.4. [Q9XEE2-1]
UniGeneiAt.20837.

3D structure databases

ProteinModelPortaliQ9XEE2.
SMRiQ9XEE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi21868. 2 interactors.
IntActiQ9XEE2. 1 interactor.
STRINGi3702.AT5G65020.1.

PTM databases

iPTMnetiQ9XEE2.

Proteomic databases

PaxDbiQ9XEE2.
PRIDEiQ9XEE2.

Protocols and materials databases

DNASUi836626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G65020.1; AT5G65020.1; AT5G65020. [Q9XEE2-1]
GeneIDi836626.
GrameneiAT5G65020.1; AT5G65020.1; AT5G65020.
KEGGiath:AT5G65020.

Organism-specific databases

TAIRiAT5G65020.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158802.
InParanoidiQ9XEE2.
OMAiHYNDAFG.
OrthoDBiEOG09360FWC.
PhylomeDBiQ9XEE2.

Enzyme and pathway databases

ReactomeiR-ATH-114608. Platelet degranulation.
R-ATH-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ9XEE2.

Gene expression databases

ExpressionAtlasiQ9XEE2. baseline and differential.
GenevisibleiQ9XEE2. AT.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR009118. Annexin_pln.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01814. ANNEXINPLANT.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXD2_ARATH
AccessioniPrimary (citable) accession number: Q9XEE2
Secondary accession number(s): Q42063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.