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Protein

Annexin D2

Gene

ANN2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate regulated, targeted secretion of Golgi-derived vesicles during seedling development.

GO - Molecular functioni

GO - Biological processi

  • polysaccharide transport Source: TAIR
  • response to cold Source: TAIR
  • response to heat Source: TAIR
  • response to salt stress Source: TAIR
  • response to water deprivation Source: TAIR

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-ATH-114608 Platelet degranulation
R-ATH-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin D2
Alternative name(s):
AnnAt2
Gene namesi
Name:ANN2
Synonyms:ANNAT2
Ordered Locus Names:At5g65020
ORF Names:MXK3.27
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G65020
TAIRilocus:2177709 AT5G65020

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002788162 – 317Annexin D2Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei95Phosphoserine1 Publication1
Modified residuei100Phosphothreonine1 Publication1
Modified residuei112PhosphothreonineBy similarity1
Modified residuei129Phosphotyrosine1 Publication1
Modified residuei284PhosphotyrosineBy similarity1
Modified residuei289PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9XEE2
PRIDEiQ9XEE2

PTM databases

iPTMnetiQ9XEE2

Expressioni

Tissue specificityi

Expressed mainly in roots and flowers. Low in stems and bearly detectable in leaves.1 Publication

Developmental stagei

In germinating seedlings, expressed in root, hypocotyl and cotyledon epidermal cells. By day 4, expression expands in the root endodermis and throughout initiating lateral roots. As the seedling matures, expression in the hypocotyl and cotyledons decreases and by day 14, expression is restricted to creases between the shoot meristem and its lateral primordia.1 Publication

Inductioni

Up-regulated by heat shock stress. Down-regulated by cold, dehydration, and salt stresses.1 Publication

Gene expression databases

ExpressionAtlasiQ9XEE2 baseline and differential
GenevisibleiQ9XEE2 AT

Interactioni

Protein-protein interaction databases

BioGridi21868, 2 interactors
IntActiQ9XEE2, 1 interactor
MINTiQ9XEE2
STRINGi3702.AT5G65020.1

Structurei

3D structure databases

ProteinModelPortaliQ9XEE2
SMRiQ9XEE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 80Annexin 1Add BLAST66
Repeati87 – 152Annexin 2Add BLAST66
Repeati170 – 236Annexin 3Add BLAST67
Repeati246 – 311Annexin 4Add BLAST66

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
HOGENOMiHOG000158802
InParanoidiQ9XEE2
KOiK17098
OMAiLSINKMG
OrthoDBiEOG09360FWC
PhylomeDBiQ9XEE2

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR009118 AnnexinD_plant
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01814 ANNEXINPLANT
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9XEE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLKVPSNV PLPEDDAEQL HKAFSGWGTN EKLIISILAH RNAAQRSLIR
60 70 80 90 100
SVYAATYNED LLKALDKELS SDFERAVMLW TLDPPERDAY LAKESTKMFT
110 120 130 140 150
KNNWVLVEIA CTRPALELIK VKQAYQARYK KSIEEDVAQH TSGDLRKLLL
160 170 180 190 200
PLVSTFRYEG DDVNMMLARS EAKILHEKVS EKSYSDDDFI RILTTRSKAQ
210 220 230 240 250
LGATLNHYNN EYGNAINKNL KEESDDNDYM KLLRAVITCL TYPEKHFEKV
260 270 280 290 300
LRLSINKMGT DEWGLTRVVT TRTEVDMERI KEEYQRRNSI PLDRAIAKDT
310
SGDYEDMLVA LLGHGDA
Length:317
Mass (Da):36,266
Last modified:November 1, 1999 - v1
Checksum:i8A643FA4BFE780E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118 – 122LIKVK → FIQG in CAA81121 (PubMed:8281187).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083914 mRNA Translation: AAD34237.1
AB019236 Genomic DNA Translation: BAA97314.1
CP002688 Genomic DNA Translation: AED97986.1
AY070400 mRNA Translation: AAL49896.1
AY096577 mRNA Translation: AAM20227.1
AY085713 mRNA Translation: AAM62931.1
Z25968 mRNA Translation: CAA81121.1
RefSeqiNP_201307.1, NM_125901.4 [Q9XEE2-1]
UniGeneiAt.20837

Genome annotation databases

EnsemblPlantsiAT5G65020.1; AT5G65020.1; AT5G65020 [Q9XEE2-1]
GeneIDi836626
GrameneiAT5G65020.1; AT5G65020.1; AT5G65020 [Q9XEE2-1]
KEGGiath:AT5G65020

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANXD2_ARATH
AccessioniPrimary (citable) accession number: Q9XEE2
Secondary accession number(s): Q42063
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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