Q9XDZ7 (MURI_CORGL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate racemase
EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	Cgl2509, cg2762

Organism

Corynebacterium glutamicum (Brevibacterium flavum)

Taxonomic identifier

1718 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.
Sequence caution	The sequence BAA78374.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB99902.1 differs from that shown. Reason: Erroneous initiation. The sequence CAF21172.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Glutamate racemase HAMAP MF_00258		PRO_0000095468
Experimental info
	Sequence conflict	144	1	V → E in BAA78374. Ref.1
	Sequence conflict	267	1	Q → L in BAA78374. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9XDZ7 [UniParc]. Last modified July 11, 2002. Version 3. Checksum: B332C3DB9A1477C1	FASTA	273	29,230
	10 20 30 40 50 60 MIERPVPGAD APIGIFDSGV GGLTVARTII DQLPHESVIY IGDTANGPYG PLPIAKVREH 70 80 90 100 110 120 AIRIADELVE RGCKMIVIAC NTASAAFLRD ARERYSVPVV EVILPAVRRA VASTRNGKVG 130 140 150 160 170 180 VIGTVGTINS GAYQDLFSAS PSIVVNAVAC PRFVDFVERG ITSGRQILNI AQDYLEPLQA 190 200 210 220 230 240 EGVDTLVLGC THYPLLSGVI QLAMGDHVSL VSSAEETAKD VLRILSQQDL LADPDMHPEP 250 260 270 SYSFESTGDP EIFAQLSRRF LGPIVSQVRQ NEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of the murI gene from Brevibacterium lactofermentum ATCC 13869 encoding D-glutamate racemase." Malathi K.C., Wachi M., Nagai K. FEMS Microbiol. Lett. 175:193-196(1999) [PubMed: 10386367] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 13869 / DSMZ 1412 / NCIMB 9567.
[2]	"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032." Nakagawa S. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[3]	"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB020624 Genomic DNA. Translation: BAA78374.1. Different initiation. BA000036 Genomic DNA. Translation: BAB99902.1. Different initiation. BX927155 Genomic DNA. Translation: CAF21172.1. Different initiation.
RefSeq	NP_601711.1. NC_003450.3. YP_226751.1. NC_006958.1.
3D structure databases
ProteinModelPortal	Q9XDZ7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1020457. 3342768.
GenomeReviews	Gene locus Cgl2509 in contig BA000036_GR. Gene locus cg2762 in contig BX927147_GR.
KEGG	cgb:cg2762. cgl:NCgl2423.
PATRIC	21497034. VBICorGlu203724_2442.
Phylogenomic databases
HOGENOM	HBG645102.
OMA	PQEDTIY.
PhylomeDB	Q9XDZ7.
ProtClustDB	PRK00865.
Enzyme and pathway databases
BioCyc	CGLU196627:CG2762-MONOMER.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
KO	K01776.
PANTHER	PTHR21198. PTHR21198. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
SUPFAM	SSF53681. Asp/Glu_race. 2 hits.
TIGRFAMs	TIGR00067. Glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_CORGL

Accession

Primary (citable) accession number: Q9XDZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 11, 2002
Last modified:	January 25, 2012
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program