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Q9XDU6

- LUXS_CLOPE

UniProt

Q9XDU6 - LUXS_CLOPE

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Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).1 Publication

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541IronBy similarity
Metal bindingi58 – 581IronBy similarity
Metal bindingi121 – 1211IronBy similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCPER195102:GJFM-203-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:CPE0178
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 151151S-ribosylhomocysteine lyasePRO_0000172217Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi195102.CPE0178.

Structurei

3D structure databases

ProteinModelPortaliQ9XDU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.Curated

Phylogenomic databases

eggNOGiCOG1854.
HOGENOMiHOG000040372.
KOiK07173.
OMAiKWEDVPG.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XDU6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKVESFELD HTKVKAPYVR KAGIKIGPKG DIVSKFDLRF VQPNKELLSD
60 70 80 90 100
KGMHTLEHFL AGFMREKLDD VIDISPMGCK TGFYLTSFGD IDVKDIIEAL
110 120 130 140 150
EYSLSKVLEQ EEIPAANELQ CGSAKLHSLE LAKSHAKQVL ENGISDKFYV

E
Length:151
Mass (Da):16,932
Last modified:November 1, 1999 - v1
Checksum:iF9564886EBF75561
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028629 Genomic DNA. Translation: BAA81641.1.
BA000016 Genomic DNA. Translation: BAB79884.1.
PIRiT43793.
RefSeqiNP_561094.1. NC_003366.1.
WP_003452649.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB79884; BAB79884; BAB79884.
GeneIDi988419.
KEGGicpe:CPE0178.
PATRICi19494236. VBICloPer59675_0235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028629 Genomic DNA. Translation: BAA81641.1 .
BA000016 Genomic DNA. Translation: BAB79884.1 .
PIRi T43793.
RefSeqi NP_561094.1. NC_003366.1.
WP_003452649.1. NC_003366.1.

3D structure databases

ProteinModelPortali Q9XDU6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE0178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB79884 ; BAB79884 ; BAB79884 .
GeneIDi 988419.
KEGGi cpe:CPE0178.
PATRICi 19494236. VBICloPer59675_0235.

Phylogenomic databases

eggNOGi COG1854.
HOGENOMi HOG000040372.
KOi K07173.
OMAi KWEDVPG.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci CPER195102:GJFM-203-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel VirR/VirS-regulated genes in Clostridium perfringens."
    Banu S., Ohtani K., Yaguchi H., Swe T., Cole S.T., Hayashi H., Shimizu T.
    Mol. Microbiol. 35:854-864(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 13 / Type A.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.
  3. "The luxS gene is involved in cell-cell signalling for toxin production in Clostridium perfringens."
    Ohtani K., Hayashi H., Shimizu T.
    Mol. Microbiol. 44:171-179(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLUXS_CLOPE
AccessioniPrimary (citable) accession number: Q9XDU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3