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Q9XDP3

- ALF_NOSCO

UniProt

Q9XDP3 - ALF_NOSCO

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Protein
Fructose-bisphosphate aldolase
Gene
fba, fda
Organism
Nostoc commune
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Glyceraldehyde 3-phosphate By similarity
Active sitei83 – 831Proton donor By similarity
Metal bindingi84 – 841Zinc 1; catalytic By similarity
Metal bindingi105 – 1051Zinc 2 By similarity
Metal bindingi142 – 1421Zinc 2 By similarity
Metal bindingi198 – 1981Zinc 1; catalytic By similarity
Binding sitei199 – 1991Dihydroxyacetone phosphate; via amide nitrogen By similarity
Metal bindingi232 – 2321Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:fda
OrganismiNostoc commune
Taxonomic identifieri1178 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Fructose-bisphosphate aldolase
PRO_0000178724Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9XDP3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni233 – 2353Dihydroxyacetone phosphate binding By similarity
Regioni275 – 2784Dihydroxyacetone phosphate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006412. Fruct_bisP_Calv.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01521. FruBisAldo_II_B. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XDP3-1 [UniParc]FASTAAdd to Basket

« Hide

MALVPLRLLL DHAAENGYGI PAFNVNNLEQ IQAILKAAVE TDSPVILQAS    50
RGARAYAGEN FLRHLILAAV ETYPHIPIVM HQDHGNAPAT CYSAIKNNFT 100
SVMMDGSLEA DAKTPASFEY NVNVTREVVN VAHALGVSVE GELGCLGSLE 150
TGAGEAEDGH GFEGTLDHSQ LLTDPDEAVE FVEATQVDAL AVAIGTSHGA 200
YKFTRKPTGE ILAISRIEEI HRRLPNTHLV MHGSSSVPED LLALINQYGG 250
AIPETYGVPV EEIQKGIKSG VRKVNIDTDN RLAITAAVRE ACAKKPEEFD 300
PRHFLKPSIT YMQKVCAERY QQFGTAGNAS KIKQISLEDF AAKYAKGELN 350
VVTKAAAKV 359
Length:359
Mass (Da):38,698
Last modified:November 1, 1999 - v1
Checksum:i921CA84C3D4E6673
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005512 Genomic DNA. Translation: AAD37811.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005512 Genomic DNA. Translation: AAD37811.1 .

3D structure databases

ProteinModelPortali Q9XDP3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006412. Fruct_bisP_Calv.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01521. FruBisAldo_II_B. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, characterization and expression of a class II fructose-1,6-bisphosphate aldolase gene from Nostoc commune UTEX 584 (Cyanobacteria)."
    Joardar V., Ehling-Schulz M., Smith S.C., Scherer S., Potts M.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: UTEX 584.

Entry informationi

Entry nameiALF_NOSCO
AccessioniPrimary (citable) accession number: Q9XDP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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