Reviewed, UniProtKB/Swiss-Prot Q9XD78 (QUIA_XANCJ)

Names and origin

Protein names

Recommended name:
    Probable quinate dehydrogenase [Pyrroloquinoline-quinone]
    EC=1.1.99.25

Gene names

Name:

qumA

Organism

Xanthomonas campestris pv. juglandis (Xanthomonas arboricola pv. juglandis)

Taxonomic identifier

195709 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	790 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Quinate + pyrroloquinoline-quinone = 3-dehydroquinate + reduced pyrroloquinoline-quinone.
Cofactor	PQQ By similarity.
Pathway	Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3-dehydroquinate from quinate (PQQ route): step 1/1.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the bacterial PQQ dehydrogenase family.

Ontologies

Keywords
Biological process	Quinate metabolism
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Oxidoreductase
PTM	PQQ
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW quinate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro quinate dehydrogenase (pyrroloquinoline-quinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 790	790	Probable quinate dehydrogenase [Pyrroloquinoline-quinone]		PRO_0000205341
Regions
	Transmembrane	22 – 42	21	Potential
	Transmembrane	48 – 68	21	Potential
	Transmembrane	77 – 94	18	Potential
	Transmembrane	106 – 126	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9XD78-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: B75F29B52A49FE6F	FASTA	790	82,897
	10 20 30 40 50 60 MLIALVGLIF LLGGARLASL GGSWYFLLMG LATALAGVLI VLRRPAGALV YGVAFALTLV 70 80 90 100 110 120 WALWDAGLEF WPLVSRLMLP AAFAVLVALA WPALRRSRAL PTGRTAYGVA TVLALAVVAG 130 140 150 160 170 180 IGGMFVPHPP VAGNAGPGMT AVPPGSVQQN WSAYGNTDGG SRFAALDQIN RSNGRPAAGS 190 200 210 220 230 240 PGPTTPGEIA NSDGNGAEDQ LTPLQVGEKV FLCTPHNNLI ALDASTGKQL WRREINATSS 250 260 270 280 290 300 VWQRCRGLGY FDADAALPAP SVANPSPIAA VTVAQGANCR RRLFTNTIDG RLIAVDADTG 310 320 330 340 350 360 AFCQGFGSNG QVDLKAGLGA APDPFYQLTS PPLVAGTTVV GGRTRADDNV QTDMPGGVVR 370 380 390 400 410 420 GSMWSPVRSA GLDPGNPHDR QAPAAGSSYV RSTPNVWAPM SYDAAMNTVF LPLGGPSTDL 430 440 450 460 470 480 YGAERTALDH RYGASVLALD ATTGAEKWVY QTVHNDLWDF DLPMQPSLID FPNQDGSHTP 490 500 510 520 530 540 AVVIGTKAGQ IYVLDRATGK PLTEVREVPV KGSDIAHEQY APTQPLSVGM PQIGTKHLTE 550 560 570 580 590 600 SDMWGATAMD QMLCRIAFKQ MRYEGLYTAP GTDVSLSFPG SLGGMNWGGL STDPVHDVVF 610 620 630 640 650 660 ANDMRLGLWV QMIPADTRKA EAAGGGEAVN TGMGAVPLKG TPYAVNKNRF LSALGIPCQA 670 680 690 700 710 720 PPYGTLSAID LKTRSIAWQV PVGTVQDTGP FGIKMHLPIP IGMPTLGGTL STQGGLVFIA 730 740 750 760 770 780 GTQDYYLRAF DSATGKELWK GRLPVGSQGG PITYVSHKTG KQYVVISAGG ARQSPDRGDY 790 VIAYSLPDAH

References

[1]	"A gene involved in quinate metabolism is specific to one DNA homology group of Xanthomonas campestris." Lee Y.-A., Lo Y.-C., Yu P.-P. J. Appl. Microbiol. 87:649-658(1999) [PubMed: 10594704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF109471 Genomic DNA. Translation: AAD38453.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.99.25. 295646.
Family and domain databases
InterPro	IPR017511. PQQ-dep_membr-bd_DH. IPR019556. PQQ-dependent_C. IPR019551. PQQ-dependent_N. IPR018391. PQQ_beta_propeller_repeat. IPR002372. PQQ_repeat. IPR011047. Quino_AlcDH-like. IPR001479. Quinoprotein_DH_CS. [Graphical view]
Gene3D	G3DSA:2.140.10.10. Quinoprotein_alc_DH-like. 1 hit.
Pfam	PF01011. PQQ. 4 hits. PF10535. PQQ_C. 1 hit. PF10527. PQQ_N. 1 hit. [Graphical view]
SMART	SM00564. PQQ. 5 hits. [Graphical view]
TIGRFAMs	TIGR03074. PQQ_membr_DH. 1 hit.
PROSITE	PS00363. BACTERIAL_PQQ_1. False negative. PS00364. BACTERIAL_PQQ_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QUIA_XANCJ

Accession

Primary (citable) accession number: Q9XD78

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)