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Q9XD73

- NRDJ_STRCT

UniProt

Q9XD73 - NRDJ_STRCT

Protein

Vitamin B12-dependent ribonucleotide reductase

Gene

nrdJ

Organism
Streptomyces cattleya
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    5'-deoxyadenosylcobalamine (coenzyme B12).By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: UniProtKB-KW
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    Cobalamin, Cobalt, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vitamin B12-dependent ribonucleotide reductase (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleoside-diphosphate reductase NrdJ
    Gene namesi
    Name:nrdJ
    OrganismiStreptomyces cattleya
    Taxonomic identifieri29303 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 599599Vitamin B12-dependent ribonucleotide reductasePRO_0000231662Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XD73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni193 – 1975Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR024434. TSCPD_dom.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    PF12637. TSCPD. 1 hit.
    [Graphical view]
    PRINTSiPR01183. RIBORDTASEM1.

    Sequencei

    Sequence statusi: Fragment.

    Q9XD73-1 [UniParc]FASTAAdd to Basket

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    MHLDNSSCNL ASLNLMKFLR DDTASDGASG AGGNMSLDAE RFAKVVELVI    50
    TAMDISICFA DFPTEKIGET TRAFRQLGIG YANLGALLMA TGHAYDSDGG 100
    RALAGAITSL MTGTSYRRSA ELAAVVGPYE GYARNADAHK RVMRQHADAN 150
    TAAQRMDDLD TPVWAAATEA WQDVLRLGEQ NRFRNAQASV LAPTGTIGLM 200
    MDCDTTGVEP DLALVKFKKL VGGGSMQIVN NTVPKALKRL GYQPEQVEAV 250
    VAHIAEHGNV IDAPGLKPEH YEVFDCAMGE RAISPMGHVR MMAAAQPFLS 300
    GAISKTVNMP ESATVEEIEE IYYEGWKLGL KALAIYRDNC KVGQPLSAKK 350
    KEEAKTEAPA EVEKVVEYRP VRKRLPKGRP GITTSFTVGG AEGYMTANSY 400
    PDDGLGEVFL KMSKQGSTLA GMMDAFSIAV SVGLQYGVPL ETYVSKFTNM 450
    RFEPAGLTDD PDVRMAQSIV DYIFRRLALD FLPFETRSAL GIHSAEERQR 500
    HLDTGSYEPA EDELDVEGLA QSAPRQAGPA KAATTAPAAK AQEPAAAPSP 550
    KQAHNSTELL EIQQGLNADA PLCFSCGTKM RRAGSCYVCE GCGSTSGCS 599
    Length:599
    Mass (Da):64,236
    Last modified:November 1, 1999 - v1
    Checksum:i8679481ADA46B037
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111267 Genomic DNA. Translation: AAD37499.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111267 Genomic DNA. Translation: AAD37499.1 .

    3D structure databases

    ProteinModelPortali Q9XD73.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR024434. TSCPD_dom.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    PF12637. TSCPD. 1 hit.
    [Graphical view ]
    PRINTSi PR01183. RIBORDTASEM1.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a regulatory gene from Streptomyces cattleya and study on its cis-acting element."
      Shang G., Wang Y.
      Sci. China, Ser. C, Life Sci. 43:418-424(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiNRDJ_STRCT
    AccessioniPrimary (citable) accession number: Q9XD73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3