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Q9XD73 (NRDJ_STRCT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vitamin B12-dependent ribonucleotide reductase

EC=1.17.4.1
Alternative name(s):
Ribonucleoside-diphosphate reductase NrdJ
Gene names
Name:nrdJ
OrganismStreptomyces cattleya
Taxonomic identifier29303 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length599 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

5'-deoxyadenosylcobalamine (coenzyme B12) By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase class-2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 599599Vitamin B12-dependent ribonucleotide reductase
PRO_0000231662

Regions

Region193 – 1975Substrate binding By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q9XD73 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 8679481ADA46B037

FASTA59964,236
        10         20         30         40         50         60 
MHLDNSSCNL ASLNLMKFLR DDTASDGASG AGGNMSLDAE RFAKVVELVI TAMDISICFA 

        70         80         90        100        110        120 
DFPTEKIGET TRAFRQLGIG YANLGALLMA TGHAYDSDGG RALAGAITSL MTGTSYRRSA 

       130        140        150        160        170        180 
ELAAVVGPYE GYARNADAHK RVMRQHADAN TAAQRMDDLD TPVWAAATEA WQDVLRLGEQ 

       190        200        210        220        230        240 
NRFRNAQASV LAPTGTIGLM MDCDTTGVEP DLALVKFKKL VGGGSMQIVN NTVPKALKRL 

       250        260        270        280        290        300 
GYQPEQVEAV VAHIAEHGNV IDAPGLKPEH YEVFDCAMGE RAISPMGHVR MMAAAQPFLS 

       310        320        330        340        350        360 
GAISKTVNMP ESATVEEIEE IYYEGWKLGL KALAIYRDNC KVGQPLSAKK KEEAKTEAPA 

       370        380        390        400        410        420 
EVEKVVEYRP VRKRLPKGRP GITTSFTVGG AEGYMTANSY PDDGLGEVFL KMSKQGSTLA 

       430        440        450        460        470        480 
GMMDAFSIAV SVGLQYGVPL ETYVSKFTNM RFEPAGLTDD PDVRMAQSIV DYIFRRLALD 

       490        500        510        520        530        540 
FLPFETRSAL GIHSAEERQR HLDTGSYEPA EDELDVEGLA QSAPRQAGPA KAATTAPAAK 

       550        560        570        580        590 
AQEPAAAPSP KQAHNSTELL EIQQGLNADA PLCFSCGTKM RRAGSCYVCE GCGSTSGCS 

« Hide

References

[1]"Cloning of a regulatory gene from Streptomyces cattleya and study on its cis-acting element."
Shang G., Wang Y.
Sci. China, Ser. C, Life Sci. 43:418-424(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF111267 Genomic DNA. Translation: AAD37499.1.

3D structure databases

ProteinModelPortalQ9XD73.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000788. RNR_lg_C.
IPR024434. TSCPD_dom.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
PF12637. TSCPD. 1 hit.
[Graphical view]
PRINTSPR01183. RIBORDTASEM1.
ProtoNetSearch...

Entry information

Entry nameNRDJ_STRCT
AccessionPrimary (citable) accession number: Q9XD73
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families