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Q9XD73

- NRDJ_STRCT

UniProt

Q9XD73 - NRDJ_STRCT

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Protein

Vitamin B12-dependent ribonucleotide reductase

Gene
nrdJ
Organism
Streptomyces cattleya
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

5'-deoxyadenosylcobalamine (coenzyme B12) By similarity.

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

Cobalamin, Cobalt, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin B12-dependent ribonucleotide reductase (EC:1.17.4.1)
Alternative name(s):
Ribonucleoside-diphosphate reductase NrdJ
Gene namesi
Name:nrdJ
OrganismiStreptomyces cattleya
Taxonomic identifieri29303 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Vitamin B12-dependent ribonucleotide reductasePRO_0000231662Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9XD73.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni193 – 1975Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR024434. TSCPD_dom.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF12637. TSCPD. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.

Sequencei

Sequence statusi: Fragment.

Q9XD73-1 [UniParc]FASTAAdd to Basket

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MHLDNSSCNL ASLNLMKFLR DDTASDGASG AGGNMSLDAE RFAKVVELVI    50
TAMDISICFA DFPTEKIGET TRAFRQLGIG YANLGALLMA TGHAYDSDGG 100
RALAGAITSL MTGTSYRRSA ELAAVVGPYE GYARNADAHK RVMRQHADAN 150
TAAQRMDDLD TPVWAAATEA WQDVLRLGEQ NRFRNAQASV LAPTGTIGLM 200
MDCDTTGVEP DLALVKFKKL VGGGSMQIVN NTVPKALKRL GYQPEQVEAV 250
VAHIAEHGNV IDAPGLKPEH YEVFDCAMGE RAISPMGHVR MMAAAQPFLS 300
GAISKTVNMP ESATVEEIEE IYYEGWKLGL KALAIYRDNC KVGQPLSAKK 350
KEEAKTEAPA EVEKVVEYRP VRKRLPKGRP GITTSFTVGG AEGYMTANSY 400
PDDGLGEVFL KMSKQGSTLA GMMDAFSIAV SVGLQYGVPL ETYVSKFTNM 450
RFEPAGLTDD PDVRMAQSIV DYIFRRLALD FLPFETRSAL GIHSAEERQR 500
HLDTGSYEPA EDELDVEGLA QSAPRQAGPA KAATTAPAAK AQEPAAAPSP 550
KQAHNSTELL EIQQGLNADA PLCFSCGTKM RRAGSCYVCE GCGSTSGCS 599
Length:599
Mass (Da):64,236
Last modified:November 1, 1999 - v1
Checksum:i8679481ADA46B037
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111267 Genomic DNA. Translation: AAD37499.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111267 Genomic DNA. Translation: AAD37499.1 .

3D structure databases

ProteinModelPortali Q9XD73.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR024434. TSCPD_dom.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
PF12637. TSCPD. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
ProtoNeti Search...

Publicationsi

  1. "Cloning of a regulatory gene from Streptomyces cattleya and study on its cis-acting element."
    Shang G., Wang Y.
    Sci. China, Ser. C, Life Sci. 43:418-424(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNRDJ_STRCT
AccessioniPrimary (citable) accession number: Q9XD73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3