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Q9XCX9

- RNC_PSEAE

UniProt

Q9XCX9 - RNC_PSEAE

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Protein

Ribonuclease 3

Gene
rnc, PA0770
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+ By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi40 – 401Magnesium By similarity
Active sitei44 – 441 Reviewed prediction
Metal bindingi113 – 1131Magnesium By similarity
Active sitei116 – 1161 By similarity
Metal bindingi116 – 1161Magnesium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-HAMAP
  3. rRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
Name:rnc
Ordered Locus Names:PA0770
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA0770.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Ribonuclease 3UniRule annotationPRO_0000180419Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA0770.

Structurei

3D structure databases

ProteinModelPortaliQ9XCX9.
SMRiQ9XCX9. Positions 5-215.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 127123RNase IIIAdd
BLAST
Domaini154 – 22471DRBMAdd
BLAST

Sequence similaritiesi

Contains 1 RNase III domain.

Phylogenomic databases

eggNOGiCOG0571.
KOiK03685.
OMAiTFKDQEL.
OrthoDBiEOG6T1WVS.
PhylomeDBiQ9XCX9.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XCX9-1 [UniParc]FASTAAdd to Basket

« Hide

MSNSLDRLER KLGYTFKDRD LMVLALTHRS YAGRNNERLE FLGDAILNFV    50
IGEALFHHFP QAREGQLSRL RARLVKGETL ALLARGFEVG DYLRLGSGEL 100
KSGGFRRESI LADAMEALIG AIYLDTGMDS ARERIIAWLG PQLRELTPVD 150
TNKDPKTRLQ EFLQSRGCDL PRYEVVDIQG EPHCRTFFVD CEVALLSDKT 200
HGHGGSRRIA EQVAAAAALV ALGVENGHD 229
Length:229
Mass (Da):25,506
Last modified:November 1, 1999 - v1
Checksum:i9D884F21A0088B6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF123492 Genomic DNA. Translation: AAD40229.1.
AE004091 Genomic DNA. Translation: AAG04159.1.
PIRiE83548.
RefSeqiNP_249461.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04159; AAG04159; PA0770.
GeneIDi882139.
KEGGipae:PA0770.
PATRICi19835814. VBIPseAer58763_0800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF123492 Genomic DNA. Translation: AAD40229.1 .
AE004091 Genomic DNA. Translation: AAG04159.1 .
PIRi E83548.
RefSeqi NP_249461.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q9XCX9.
SMRi Q9XCX9. Positions 5-215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA0770.

Protocols and materials databases

DNASUi 882139.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG04159 ; AAG04159 ; PA0770 .
GeneIDi 882139.
KEGGi pae:PA0770.
PATRICi 19835814. VBIPseAer58763_0800.

Organism-specific databases

PseudoCAPi PA0770.

Phylogenomic databases

eggNOGi COG0571.
KOi K03685.
OMAi TFKDQEL.
OrthoDBi EOG6T1WVS.
PhylomeDBi Q9XCX9.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and analysis of the rnc-era-recO operon from Pseudomonas aeruginosa."
    Powell B.S., Peters H.K. III, Nakamura Y., Court D.L.
    J. Bacteriol. 181:5111-5113(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PAK.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiRNC_PSEAE
AccessioniPrimary (citable) accession number: Q9XCX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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