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Q9XCX9

- RNC_PSEAE

UniProt

Q9XCX9 - RNC_PSEAE

Protein

Ribonuclease 3

Gene

rnc

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

    Cofactori

    Mg2+.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi40 – 401MagnesiumUniRule annotation
    Active sitei44 – 441UniRule annotation
    Metal bindingi113 – 1131MagnesiumUniRule annotation
    Active sitei116 – 1161UniRule annotation
    Metal bindingi116 – 1161MagnesiumUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease III activity Source: UniProtKB-HAMAP
    3. rRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-HAMAP
    2. rRNA catabolic process Source: InterPro
    3. rRNA processing Source: UniProtKB-HAMAP
    4. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    mRNA processing, rRNA processing, tRNA processing

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding, rRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
    Alternative name(s):
    Ribonuclease IIIUniRule annotation
    Short name:
    RNase IIIUniRule annotation
    Gene namesi
    Name:rncUniRule annotation
    Ordered Locus Names:PA0770
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA0770.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Ribonuclease 3PRO_0000180419Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi208964.PA0770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XCX9.
    SMRiQ9XCX9. Positions 5-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 127123RNase IIIUniRule annotationAdd
    BLAST
    Domaini154 – 22471DRBMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DRBM (double-stranded RNA-binding) domain.UniRule annotation
    Contains 1 RNase III domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0571.
    KOiK03685.
    OMAiTFKDQEL.
    OrthoDBiEOG6T1WVS.
    PhylomeDBiQ9XCX9.

    Family and domain databases

    Gene3Di1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PANTHERiPTHR11207. PTHR11207. 1 hit.
    PfamiPF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view]
    SUPFAMiSSF69065. SSF69065. 1 hit.
    TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
    PROSITEiPS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XCX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNSLDRLER KLGYTFKDRD LMVLALTHRS YAGRNNERLE FLGDAILNFV    50
    IGEALFHHFP QAREGQLSRL RARLVKGETL ALLARGFEVG DYLRLGSGEL 100
    KSGGFRRESI LADAMEALIG AIYLDTGMDS ARERIIAWLG PQLRELTPVD 150
    TNKDPKTRLQ EFLQSRGCDL PRYEVVDIQG EPHCRTFFVD CEVALLSDKT 200
    HGHGGSRRIA EQVAAAAALV ALGVENGHD 229
    Length:229
    Mass (Da):25,506
    Last modified:November 1, 1999 - v1
    Checksum:i9D884F21A0088B6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123492 Genomic DNA. Translation: AAD40229.1.
    AE004091 Genomic DNA. Translation: AAG04159.1.
    PIRiE83548.
    RefSeqiNP_249461.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG04159; AAG04159; PA0770.
    GeneIDi882139.
    KEGGipae:PA0770.
    PATRICi19835814. VBIPseAer58763_0800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123492 Genomic DNA. Translation: AAD40229.1 .
    AE004091 Genomic DNA. Translation: AAG04159.1 .
    PIRi E83548.
    RefSeqi NP_249461.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q9XCX9.
    SMRi Q9XCX9. Positions 5-215.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA0770.

    Protocols and materials databases

    DNASUi 882139.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG04159 ; AAG04159 ; PA0770 .
    GeneIDi 882139.
    KEGGi pae:PA0770.
    PATRICi 19835814. VBIPseAer58763_0800.

    Organism-specific databases

    PseudoCAPi PA0770.

    Phylogenomic databases

    eggNOGi COG0571.
    KOi K03685.
    OMAi TFKDQEL.
    OrthoDBi EOG6T1WVS.
    PhylomeDBi Q9XCX9.

    Family and domain databases

    Gene3Di 1.10.1520.10. 1 hit.
    3.30.160.20. 1 hit.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    PANTHERi PTHR11207. PTHR11207. 1 hit.
    Pfami PF00035. dsrm. 1 hit.
    PF14622. Ribonucleas_3_3. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 1 hit.
    SM00535. RIBOc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69065. SSF69065. 1 hit.
    TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
    PROSITEi PS50137. DS_RBD. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and analysis of the rnc-era-recO operon from Pseudomonas aeruginosa."
      Powell B.S., Peters H.K. III, Nakamura Y., Court D.L.
      J. Bacteriol. 181:5111-5113(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: PAK.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiRNC_PSEAE
    AccessioniPrimary (citable) accession number: Q9XCX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3