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Q9XC48

- Q9XC48_9ACTO

UniProt

Q9XC48 - Q9XC48_9ACTO

Protein
Submitted name:

Peptide synthetase NRPS type II-PCP

Gene

blmI

Organism
Streptomyces verticillus
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peptide synthetase NRPS type II-PCPImported
    Gene namesi
    Name:blmIImported
    OrganismiStreptomyces verticillusImported
    Taxonomic identifieri29309 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Keywords - PTMi

    PhosphopantetheineUniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4NEOX-ray2.10A2-90[»]
    ProteinModelPortaliQ9XC48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    InterProiIPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view]
    PfamiPF00550. PP-binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47336. SSF47336. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XC48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAPRGERTR RRALERDIAA IWAETLGRDS VGPHEDFAAL GGNSIHAIKI   50
    TNRVEELVDA ELSIRVLLET RTVAGMTDHV HATLTGERDR 90
    Length:90
    Mass (Da):9,957
    Last modified:November 1, 1999 - v1
    Checksum:iD28FDB4C4D2D4C8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF210249 Genomic DNA. Translation: AAD42077.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF210249 Genomic DNA. Translation: AAD42077.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4NEO X-ray 2.10 A 2-90 [» ]
    ProteinModelPortali Q9XC48.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    InterProi IPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view ]
    Pfami PF00550. PP-binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47336. SSF47336. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a type II peptidyl carrier protein from the bleomycin producer Streptomyces verticillus ATCC 15003."
      Du L., Shen B.
      Chem. Biol. 6:507-517(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC15003Imported.
    2. "The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase."
      Du L., Sanchez C., Chen M., Edwards D.J., Shen B.
      Chem. Biol. 7:623-642(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC15003Imported.
    3. "An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003."
      Du L., Chen M., Sanchez C., Shen B.
      FEMS Microbiol. Lett. 189:171-175(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC15003Imported.
    4. "Structure of BlmI, a type-II acyl-carrier-protein from Streptomyces verticillus involved in bleomycin biosynthesis."
      Cuff M.E., Bigelow L., Bearden J., Babnigg G., Bruno C.J.P., Bingman C., Yennamalli R., Lohman J., Ma M., Shen B., Phillips Jr. G.N., Joachimiak A.
      Submitted (OCT-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-90.

    Entry informationi

    Entry nameiQ9XC48_9ACTO
    AccessioniPrimary (citable) accession number: Q9XC48
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3