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Q9XC20

- RIR2_MYCGA

UniProt

Q9XC20 - RIR2_MYCGA

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdF

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron 1By similarity
Metal bindingi121 – 1211Iron 1By similarity
Active sitei125 – 1251By similarity
Metal bindingi215 – 2151Iron 2

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMGAL710127:GC09-45-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdF
Ordered Locus Names:MYCGA0450
ORF Names:MGA_0698
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001418: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Ribonucleoside-diphosphate reductase subunit betaPRO_0000190482Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi233150.MGA_0698.

Structurei

3D structure databases

ProteinModelPortaliQ9XC20.
SMRiQ9XC20. Positions 22-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
HOGENOMiHOG000246153.
KOiK00526.
OMAiSAFLCYN.
OrthoDBiEOG68DD19.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026494. RNR_NrdF.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR04171. RNR_1b_NrdF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XC20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNNNKYYDK SFSPLGYVAN GQKGVMRSIN WNVINDPKDL EVWTRVTQNF
60 70 80 90 100
WLPEKIPVSN DLKSWNELTP EWKQLVTRTF TGLTLLDTIQ CTLGDIAQIP
110 120 130 140 150
NSLTDHEQFV YANFSFMVGV HARSYGTIFS TLNTSDEIEE AHEWVINNEK
160 170 180 190 200
LQARAKFLVP YYTSDDPLKS KIAAALMPGF LLYGGFYLPF YLAARGKLPN
210 220 230 240 250
TSDIIRLILR DKVIHNYYSG YKYRLKVQKL PKEKQEEYKK FVFEILYKLI
260 270 280 290 300
ELEKDFLREL YDGFGLADEA IAFSLYNAGK FLQNCGYESP FTPEETKISP
310 320 330
EVFAQLSARA DENHDFFSGN GSSYIMGVTE ETQDDDWEF
Length:339
Mass (Da):39,168
Last modified:November 1, 1999 - v1
Checksum:iA8711B1B51E4F47F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152114 Genomic DNA. Translation: AAD45275.1.
AE015450 Genomic DNA. Translation: AAP56395.1.
RefSeqiNP_852827.1. NC_004829.2.
WP_011113274.1. NC_004829.2.

Genome annotation databases

EnsemblBacteriaiAAP56395; AAP56395; MGA_0698.
GeneIDi1090094.
KEGGimga:MGA_0698.
PATRICi20007760. VBIMycGal115357_0048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152114 Genomic DNA. Translation: AAD45275.1 .
AE015450 Genomic DNA. Translation: AAP56395.1 .
RefSeqi NP_852827.1. NC_004829.2.
WP_011113274.1. NC_004829.2.

3D structure databases

ProteinModelPortali Q9XC20.
SMRi Q9XC20. Positions 22-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233150.MGA_0698.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP56395 ; AAP56395 ; MGA_0698 .
GeneIDi 1090094.
KEGGi mga:MGA_0698.
PATRICi 20007760. VBIMycGal115357_0048.

Phylogenomic databases

eggNOGi COG0208.
HOGENOMi HOG000246153.
KOi K00526.
OMAi SAFLCYN.
OrthoDBi EOG68DD19.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci MGAL710127:GC09-45-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026494. RNR_NrdF.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
TIGRFAMsi TIGR04171. RNR_1b_NrdF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Skamrov A.V., Gol'dman M.A., Feoktistova E.S., Bibilashvili R.S.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A5969Var.B.
  2. "The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
    Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
    Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R(low / passage 15 / clone 2).

Entry informationi

Entry nameiRIR2_MYCGA
AccessioniPrimary (citable) accession number: Q9XC20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Seems to lack two of the iron-binding residues.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3