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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdF

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Caution

Seems to lack two of the iron-binding residues.Curated

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87Iron 1By similarity1
Metal bindingi121Iron 1By similarity1
Active sitei125By similarity1
Metal bindingi215Iron 21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdF
Ordered Locus Names:MYCGA0450
ORF Names:MGA_0698
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001418 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904821 – 339Ribonucleoside-diphosphate reductase subunit betaAdd BLAST339

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9XC20
SMRiQ9XC20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000246153
KOiK00526
OMAiIGYKYQR

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.620.20, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR012348 RNR-like
IPR026494 RNR_NrdF
IPR033909 RNR_small
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF00268 Ribonuc_red_sm, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
TIGRFAMsiTIGR04171 RNR_1b_NrdF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XC20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNNKYYDK SFSPLGYVAN GQKGVMRSIN WNVINDPKDL EVWTRVTQNF
60 70 80 90 100
WLPEKIPVSN DLKSWNELTP EWKQLVTRTF TGLTLLDTIQ CTLGDIAQIP
110 120 130 140 150
NSLTDHEQFV YANFSFMVGV HARSYGTIFS TLNTSDEIEE AHEWVINNEK
160 170 180 190 200
LQARAKFLVP YYTSDDPLKS KIAAALMPGF LLYGGFYLPF YLAARGKLPN
210 220 230 240 250
TSDIIRLILR DKVIHNYYSG YKYRLKVQKL PKEKQEEYKK FVFEILYKLI
260 270 280 290 300
ELEKDFLREL YDGFGLADEA IAFSLYNAGK FLQNCGYESP FTPEETKISP
310 320 330
EVFAQLSARA DENHDFFSGN GSSYIMGVTE ETQDDDWEF
Length:339
Mass (Da):39,168
Last modified:November 1, 1999 - v1
Checksum:iA8711B1B51E4F47F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152114 Genomic DNA Translation: AAD45275.1
AE015450 Genomic DNA Translation: AAP56395.1
RefSeqiWP_011113274.1, NC_004829.2

Genome annotation databases

EnsemblBacteriaiAAP56395; AAP56395; MGA_0698
GeneIDi1090094
KEGGimga:MGA_0698

Similar proteinsi

Entry informationi

Entry nameiRIR2_MYCGA
AccessioniPrimary (citable) accession number: Q9XC20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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