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Q9XC20

- RIR2_MYCGA

UniProt

Q9XC20 - RIR2_MYCGA

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdF

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Iron 1By similarity
    Metal bindingi121 – 1211Iron 1By similarity
    Active sitei125 – 1251By similarity
    Metal bindingi215 – 2151Iron 2

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleotide biosynthetic process Source: InterPro
    3. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMGAL710127:GC09-45-MONOMER.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdF
    Ordered Locus Names:MYCGA0450
    ORF Names:MGA_0698
    OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
    Taxonomic identifieri710127 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000001418: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Ribonucleoside-diphosphate reductase subunit betaPRO_0000190482Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi233150.MGA_0698.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XC20.
    SMRiQ9XC20. Positions 22-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    HOGENOMiHOG000246153.
    KOiK00526.
    OMAiSAFLCYN.
    OrthoDBiEOG68DD19.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026494. RNR_NrdF.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    TIGRFAMsiTIGR04171. RNR_1b_NrdF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9XC20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNNNKYYDK SFSPLGYVAN GQKGVMRSIN WNVINDPKDL EVWTRVTQNF    50
    WLPEKIPVSN DLKSWNELTP EWKQLVTRTF TGLTLLDTIQ CTLGDIAQIP 100
    NSLTDHEQFV YANFSFMVGV HARSYGTIFS TLNTSDEIEE AHEWVINNEK 150
    LQARAKFLVP YYTSDDPLKS KIAAALMPGF LLYGGFYLPF YLAARGKLPN 200
    TSDIIRLILR DKVIHNYYSG YKYRLKVQKL PKEKQEEYKK FVFEILYKLI 250
    ELEKDFLREL YDGFGLADEA IAFSLYNAGK FLQNCGYESP FTPEETKISP 300
    EVFAQLSARA DENHDFFSGN GSSYIMGVTE ETQDDDWEF 339
    Length:339
    Mass (Da):39,168
    Last modified:November 1, 1999 - v1
    Checksum:iA8711B1B51E4F47F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152114 Genomic DNA. Translation: AAD45275.1.
    AE015450 Genomic DNA. Translation: AAP56395.1.
    RefSeqiNP_852827.1. NC_004829.2.
    WP_011113274.1. NC_004829.2.

    Genome annotation databases

    EnsemblBacteriaiAAP56395; AAP56395; MGA_0698.
    GeneIDi1090094.
    KEGGimga:MGA_0698.
    PATRICi20007760. VBIMycGal115357_0048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152114 Genomic DNA. Translation: AAD45275.1 .
    AE015450 Genomic DNA. Translation: AAP56395.1 .
    RefSeqi NP_852827.1. NC_004829.2.
    WP_011113274.1. NC_004829.2.

    3D structure databases

    ProteinModelPortali Q9XC20.
    SMRi Q9XC20. Positions 22-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233150.MGA_0698.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP56395 ; AAP56395 ; MGA_0698 .
    GeneIDi 1090094.
    KEGGi mga:MGA_0698.
    PATRICi 20007760. VBIMycGal115357_0048.

    Phylogenomic databases

    eggNOGi COG0208.
    HOGENOMi HOG000246153.
    KOi K00526.
    OMAi SAFLCYN.
    OrthoDBi EOG68DD19.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci MGAL710127:GC09-45-MONOMER.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026494. RNR_NrdF.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    TIGRFAMsi TIGR04171. RNR_1b_NrdF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Skamrov A.V., Gol'dman M.A., Feoktistova E.S., Bibilashvili R.S.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A5969Var.B.
    2. "The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
      Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
      Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: R(low / passage 15 / clone 2).

    Entry informationi

    Entry nameiRIR2_MYCGA
    AccessioniPrimary (citable) accession number: Q9XC20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Seems to lack two of the iron-binding residues.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3