Reviewed, UniProtKB/Swiss-Prot Q9XBV2 (DSBA_YERPE)

Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein dsbA

Gene names

Name:	dsbA
Ordered Locus Names:	YPO0015, y3812, YP_0017

Organism

Yersinia pestis [Complete proteome] [HAMAP]

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins such as phoA or ompA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by dsbB. It is required for pilus biogenesis By similarity.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 207	188	Thiol:disulfide interchange protein dsbA		PRO_0000034269
Regions
	Domain	20 – 149	130	Thioredoxin
Amino acid modifications
	Disulfide bond	49 ↔ 52		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9XBV2-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: A9089DD370CAB107	FASTA	207	23,100
	10 20 30 40 50 60 MKNVWLALVG IVMAFSVTAA QFTDGKQYLT LDKPVTGEPQ VLEFFSFYCP HCYQFEEVYQ 70 80 90 100 110 120 VPKAVKKALP EGTKMTRYHV EFLGPLGKQL TQAWAVAMAL GVEEKITPLM FEGVQKTQTV 130 140 150 160 170 180 QTPGDIRNVF IKAGISGEDY DAALNSFVVK SLVAQQQKAA EDLQLRGVPA MFVNGKYMIK 190 200 NDGMDTSSMD NYVKQYADVV TFLLTQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DsbA is required for stable expression of outer membrane protein YscC and for efficient Yop secretion in Yersinia pestis." Jackson M.W., Plano G.V. J. Bacteriol. 181:5126-5130(1999) [PubMed: 10438793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: KIM.
[2]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed: 11586360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[3]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM5 / Biovar Mediaevalis.
[4]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF155130 Genomic DNA. Translation: AAD38401.1. AL590842 Genomic DNA. Translation: CAL18706.1. AE009952 Genomic DNA. Translation: AAM87357.1. AE017042 Genomic DNA. Translation: AAS60298.1.
PIR	AI0002.
RefSeq	NP_671106.1. NP_991421.1. YP_002345112.1.
3D structure databases
HSSP	HSSP built from PDB template 1A23 based on UniProtKB P24991.
SMR	Q9XBV2. Positions 20-203.
ModBase	Search...
Genome annotation databases
GeneID	1148759. 1172865. 2764564.
GenomeReviews	Gene locus y3812 in contig AE009952_GR. Gene locus YP_0017 in contig AE017042_GR. Gene locus YPO0015 in contig AL590842_GR.
KEGG	ype:YPO0015. ypk:y3812. ypm:YP_0017.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9XBV2.
OMA	Q9XBV2. EGVHYEV.
Enzyme and pathway databases
BioCyc	YPES187410:Y3812-MON. YPES214092:YPO0015-MON. YPES229193:YP0017-MON.
Family and domain databases
InterPro	IPR001853. OxRdtase_DSBA. IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_YERPE

Accession

Primary (citable) accession number: Q9XBV2
Secondary accession number(s): Q0WKS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)