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Q9XBN7

- BLAB4_ELIME

UniProt

Q9XBN7 - BLAB4_ELIME

Protein

Carbapenem-hydrolyzing beta-lactamase BlaB-4

Gene

blaB4

Organism
Elizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Hydrolyzes penicillins, cephalosporins (including cefoxitin), carbapenems and 6-beta-iodopenicillanate.By similarity

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi98 – 981Zinc 1By similarity
    Metal bindingi100 – 1001Zinc 1By similarity
    Metal bindingi102 – 1021Zinc 2By similarity
    Metal bindingi161 – 1611Zinc 1By similarity
    Metal bindingi180 – 1801Zinc 2By similarity
    Metal bindingi222 – 2221Zinc 2By similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbapenem-hydrolyzing beta-lactamase BlaB-4 (EC:3.5.2.6)
    Short name:
    CHbetaL-4
    Alternative name(s):
    Class B carbapenemase BlaB-4
    Metallo lactamase BlaB-3
    Gene namesi
    Name:blaB4
    Synonyms:blaB, blaB3
    OrganismiElizabethkingia meningoseptica (Chryseobacterium meningosepticum)
    Taxonomic identifieri238 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeElizabethkingia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 249227Carbapenem-hydrolyzing beta-lactamase BlaB-4PRO_0000016952Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XBN7.
    SMRiQ9XBN7. Positions 27-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    InterProiIPR001279. Beta-lactamas-like.
    IPR001018. Beta-lactamase_class-B_CS.
    [Graphical view]
    PfamiPF00753. Lactamase_B. 1 hit.
    [Graphical view]
    SMARTiSM00849. Lactamase_B. 1 hit.
    [Graphical view]
    SUPFAMiSSF56281. SSF56281. 1 hit.
    PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
    PS00744. BETA_LACTAMASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XBN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKKMKWALV LALGLTGLNA FGQETPEVKI EKLKDNLYVY TTYNTFNGTK    50
    YAANAVYLVT SKGVVVIDSP WGEEKFKNFT DEIYKRHGKK VIMNIATHSH 100
    DDRAGGLEYF KSLGAKTYST KMTDSILAKD NKPRAQYTFD NNKSFKVGKD 150
    EFQVYYPGKG HTADHVVVWF PKDKVLVGGC IIKSGDSKDL GFLGEAYVND 200
    WTQSVHNIQK KFPNVQYVVA GHDDWKDQTA IQHTLDLISE YQQKQKASN 249
    Length:249
    Mass (Da):28,225
    Last modified:November 1, 1999 - v1
    Checksum:iF5327FD6516153B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF162284 Genomic DNA. Translation: AAD43582.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF162284 Genomic DNA. Translation: AAD43582.1 .

    3D structure databases

    ProteinModelPortali Q9XBN7.
    SMRi Q9XBN7. Positions 27-245.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    InterProi IPR001279. Beta-lactamas-like.
    IPR001018. Beta-lactamase_class-B_CS.
    [Graphical view ]
    Pfami PF00753. Lactamase_B. 1 hit.
    [Graphical view ]
    SMARTi SM00849. Lactamase_B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56281. SSF56281. 1 hit.
    PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
    PS00744. BETA_LACTAMASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Carbapenemases of chryseobacterium (Flavobacterium) meningosepticum: distribution of blaB and characterization of a novel metallo-beta-lactamase gene, blaB3, in the type strain, NCTC 10016."
      Woodford N., Palepou M.-F.I., Babini G.S., Holmes B., Livermore D.M.
      Antimicrob. Agents Chemother. 44:1448-1452(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13253 / CIP 60.57 / DSM 2800 / LMG 12279 / NBRC 12535 / NCTC 10016.
    2. "Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum."
      Bellais S., Aubert D., Naas T., Nordmann P.
      Antimicrob. Agents Chemother. 44:1878-1886(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13253 / CIP 60.57 / DSM 2800 / LMG 12279 / NBRC 12535 / NCTC 10016.

    Entry informationi

    Entry nameiBLAB4_ELIME
    AccessioniPrimary (citable) accession number: Q9XBN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3