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Q9XBN7

- BLAB4_ELIME

UniProt

Q9XBN7 - BLAB4_ELIME

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Protein

Carbapenem-hydrolyzing beta-lactamase BlaB-4

Gene

blaB4

Organism
Elizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes penicillins, cephalosporins (including cefoxitin), carbapenems and 6-beta-iodopenicillanate.By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactori

Binds 2 zinc ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Zinc 1By similarity
Metal bindingi100 – 1001Zinc 1By similarity
Metal bindingi102 – 1021Zinc 2By similarity
Metal bindingi161 – 1611Zinc 1By similarity
Metal bindingi180 – 1801Zinc 2By similarity
Metal bindingi222 – 2221Zinc 2By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carbapenem-hydrolyzing beta-lactamase BlaB-4 (EC:3.5.2.6)
Short name:
CHbetaL-4
Alternative name(s):
Class B carbapenemase BlaB-4
Metallo lactamase BlaB-3
Gene namesi
Name:blaB4
Synonyms:blaB, blaB3
OrganismiElizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Taxonomic identifieri238 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeElizabethkingia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 249227Carbapenem-hydrolyzing beta-lactamase BlaB-4PRO_0000016952Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9XBN7.
SMRiQ9XBN7. Positions 27-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XBN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMKKMKWALV LALGLTGLNA FGQETPEVKI EKLKDNLYVY TTYNTFNGTK
60 70 80 90 100
YAANAVYLVT SKGVVVIDSP WGEEKFKNFT DEIYKRHGKK VIMNIATHSH
110 120 130 140 150
DDRAGGLEYF KSLGAKTYST KMTDSILAKD NKPRAQYTFD NNKSFKVGKD
160 170 180 190 200
EFQVYYPGKG HTADHVVVWF PKDKVLVGGC IIKSGDSKDL GFLGEAYVND
210 220 230 240
WTQSVHNIQK KFPNVQYVVA GHDDWKDQTA IQHTLDLISE YQQKQKASN
Length:249
Mass (Da):28,225
Last modified:November 1, 1999 - v1
Checksum:iF5327FD6516153B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162284 Genomic DNA. Translation: AAD43582.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF162284 Genomic DNA. Translation: AAD43582.1 .

3D structure databases

ProteinModelPortali Q9XBN7.
SMRi Q9XBN7. Positions 27-245.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Carbapenemases of chryseobacterium (Flavobacterium) meningosepticum: distribution of blaB and characterization of a novel metallo-beta-lactamase gene, blaB3, in the type strain, NCTC 10016."
    Woodford N., Palepou M.-F.I., Babini G.S., Holmes B., Livermore D.M.
    Antimicrob. Agents Chemother. 44:1448-1452(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13253 / CIP 60.57 / DSM 2800 / LMG 12279 / NBRC 12535 / NCTC 10016.
  2. "Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum."
    Bellais S., Aubert D., Naas T., Nordmann P.
    Antimicrob. Agents Chemother. 44:1878-1886(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13253 / CIP 60.57 / DSM 2800 / LMG 12279 / NBRC 12535 / NCTC 10016.

Entry informationi

Entry nameiBLAB4_ELIME
AccessioniPrimary (citable) accession number: Q9XBN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: November 1, 1999
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3