Reviewed, UniProtKB/Swiss-Prot Q9XB39 (MSRB_ENTFA)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrB
    EC=1.8.4.12
Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Synonyms:	csrA
Ordered Locus Names:	EF_3164

Organism

Enterococcus faecalis (Streptococcus faecalis) [Complete proteome] [HAMAP]

Taxonomic identifier

1351 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Enterococcaceae › Enterococcus

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Induction	By cadmium, lead, mercury, copper and manganese. HAMAP MF_01400
Sequence similarities	Belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	Peptide methionine sulfoxide reductase msrB HAMAP MF_01400		PRO_0000140274
Sites
	Active site	118	1	Nucleophile By similarity
Experimental info
	Sequence conflict	136 – 145	10	GYGEYLSLFK → AMANTFLYSNNPHFLDKYDK IVRKKATFDEYLV AA sequence Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9XB39-1 [UniParc]. Last modified April 23, 2003. Version 2. Checksum: 827563D046ED213E	FASTA	145	16,351
	10 20 30 40 50 60 MTKPTEEELK QTLTDLQYAV TQENATERPF SGEYDDFYQD GIYVDIVSGE PLFSSLDKYD 70 80 90 100 110 120 AGCGWPSFTK PIEKRGVKEK ADFSHGMHRV EVRSQEADSH LGHVFTDGPL QEGGLRYCIN 130 140 AAALRFVPVA DLEKEGYGEY LSLFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization and expression of an Enterococcus faecalis gene responsive to heavy metals." Laplace J.M., Hartke A., Giard J.-C., Auffray Y. Appl. Microbiol. Biotechnol. 53:685-689(2000) [PubMed: 10919327] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25. Strain: JH2-2.
[2]	"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis." Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A. , Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M. Science 299:2071-2074(2003) [PubMed: 12663927] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: V583 / ATCC 700802.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ243482 Genomic DNA. Translation: CAB46979.1. AE016830 Genomic DNA. Translation: AAO82838.1.
RefSeq	NP_816768.1.
3D structure databases
HSSP	HSSP built from PDB template 1L1D based on UniProtKB P14930.
ModBase	Search...
Genome annotation databases
GeneID	1202003.
GenomeReviews	Gene locus EF_3164 in contig AE016830_GR.
KEGG	efa:EF3164.
NMPDR	fig|226185.1.peg.2953.
TIGR	EF_3164.
Phylogenomic databases
HOGENOM	Q9XB39.
OMA	Q9XB39. KYESGCG.
Enzyme and pathway databases
BioCyc	EFAE226185:EF_3164-MON.
BRENDA	1.8.4.12. 704.
Family and domain databases
HAMAP	MF_01400. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
ProDom	PD004057. DUF25. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_ENTFA

Accession

Primary (citable) accession number: Q9XB39

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	April 23, 2003
Last modified:	June 16, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)