Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-quinone oxidoreductase subunit G

Gene

nuoG

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
  • [4Fe-4S] clusterBy similarityNote: Binds 3 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi65Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi68Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi82Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi116Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi120Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi123Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi129Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi169Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi172Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi175Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi219Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi245Iron-sulfur 4 (4Fe-4S)Sequence analysis1
Metal bindingi248Iron-sulfur 4 (4Fe-4S)Sequence analysis1
Metal bindingi252Iron-sulfur 4 (4Fe-4S)Sequence analysis1
Metal bindingi280Iron-sulfur 4 (4Fe-4S)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit G (EC:1.6.5.11)
Alternative name(s):
NADH dehydrogenase I subunit G
NDH-1 subunit G
Gene namesi
Name:nuoG
Ordered Locus Names:SCO4568
ORF Names:SCD16A.15c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001185631 – 843NADH-quinone oxidoreductase subunit GAdd BLAST843

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4568

Structurei

3D structure databases

ProteinModelPortaliQ9XAR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 982Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST79
Domaini100 – 1394Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST40
Domaini238 – 2944Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.Curated

Phylogenomic databases

eggNOGiENOG4108IEH Bacteria
COG1034 LUCA
HOGENOMiHOG000031440
InParanoidiQ9XAR0
KOiK00336
OMAiGYGYVNR
OrthoDBiPOG091H09JF
PhylomeDBiQ9XAR0

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR009010 Asp_de-COase-like_dom_sf
IPR006657 MoPterin_dinucl-bd_dom
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS
IPR010228 NADH_UbQ_OxRdtase_Gsu
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
PfamiView protein in Pfam
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 2 hits
PF01568 Molydop_binding, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTiView protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01973 NuoG, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00641 COMPLEX1_75K_1, 1 hit
PS00642 COMPLEX1_75K_2, 1 hit
PS00643 COMPLEX1_75K_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XAR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTTSTPSG GGAAAVPPED LVTLTIDGAE ISVPKGTLVI RAAEQLGIEI
60 70 80 90 100
PRFCDHPLLD PAGACRQCIV EVEGQRKPMA SCTITCTDGM VVKTQLTSPV
110 120 130 140 150
AEKAQHGVME LLLINHPLDC PVCDKGGECP LQNQAMSHGQ SDSRFEGKKR
160 170 180 190 200
TYEKPVPIST QVLLDRERCV LCARCTRFSN QVAGDPMIEL IERGALQQVG
210 220 230 240 250
TGEGDPFESY FSGNTIQICP VGALTSAAYR FRSRPFDLIS SPSVCEHCSG
260 270 280 290 300
GCATRTDHRR GKVMRRLAAN EPEVNEEWIC DKGRFGFRYA QQRDRLTTPL
310 320 330 340 350
VRNAEGELEP ASWPEALQIA AQGLLASRGR TGVLTGGRLT VEDAYAYSKF
360 370 380 390 400
ARVALDTNDI DFRARVHSAE EADFLAAHVA GRGRDLGGSS RTESGGGAGV
410 420 430 440 450
TYTSLEKAPA VLLVGFEAEE EAPGVFLRLR KAWRKHGQKV FSLATHATRG
460 470 480 490 500
LEKAGGTLLP AAPGTETEWL DALASGVGLE EGGTQAAEAL RAEGAVIVVG
510 520 530 540 550
ERLASVAGGL TSAVRTSAAT GARLVWIPRR AGERGAIEAG ALPSLLPGGR
560 570 580 590 600
PATDPRAREE VAALWGLADL PHRYGRDTGE IVEAAARGEL QALLVAGVEV
610 620 630 640 650
ADLPDPTRAR AALDEAGFVV SLELRPSEVS ERADVVLPVA AVAEKPGTFL
660 670 680 690 700
NWEGRVRFFE AALKPDQMTR RLAPTDARVL QMLADAMDVH LGLPDLRTTR
710 720 730 740 750
AEIDRLGAWD GPRAGEPLQT ASALPRPAAG EAVLAGHRLL LDQGLLQQGD
760 770 780 790 800
EALAGTRHAA RARLSAATAA EAGVKDGDVL AVTGPAGAVE LPLQVTEMPD
810 820 830 840
RVVWLPLNSA GSGVASDAGV LPGTLVRIGP ATPAGAAPKE VEA
Length:843
Mass (Da):88,862
Last modified:November 1, 1999 - v1
Checksum:i318D67C27AAA5193
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939120 Genomic DNA Translation: CAB44525.1
PIRiT34618
RefSeqiNP_628730.1, NC_003888.3
WP_011029735.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB44525; CAB44525; CAB44525
GeneIDi1100008
KEGGisco:SCO4568
PATRICifig|100226.15.peg.4640

Similar proteinsi

Entry informationi

Entry nameiNUOG_STRCO
AccessioniPrimary (citable) accession number: Q9XAR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health