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Protein

NADH-quinone oxidoreductase subunit A

Gene

nuoA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTransportUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit AUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit AUniRule annotation
NDH-1 subunit AUniRule annotation
NUO1UniRule annotation
Gene namesi
Name:nuoAUniRule annotation
Ordered Locus Names:SCO4562Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 28HelicalUniRule annotationAdd BLAST23
Transmembranei61 – 82HelicalUniRule annotationAdd BLAST22
Transmembranei88 – 110HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Keywords - PTMi

QuinoneUniRule annotation

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO4562

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 3 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105KWU Bacteria
COG0838 LUCA
HOGENOMiHOG000100120
InParanoidiQ9XAQ4
KOiK00330
OMAiAYEWRRG
OrthoDBiPOG091H08K0
PhylomeDBiQ9XAQ4

Family and domain databases

Gene3Di1.20.58.1610, 1 hit
HAMAPiMF_01394 NDH1_NuoA, 1 hit
InterProiView protein in InterPro
IPR023043 NAD(P)H_OxRDtase_bac/plastid
IPR000440 NADH_UbQ/plastoQ_OxRdtase_su3
IPR038430 NDAH_ubi_oxred_su3_sf
PANTHERiPTHR11058 PTHR11058, 1 hit
PfamiView protein in Pfam
PF00507 Oxidored_q4, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XAQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAYAPILVL GALGAGFAIF SVVMATLIGP KRYNRAKLEA YECGIEPTPT
60 70 80 90 100
PAGGGRFPIK YYLTAMLFII FDIEIVFLYP WAVTFDALGI FGLVEMLLFV
110
LTVFVAYAYV WRRGGLEWD
Length:119
Mass (Da):13,256
Last modified:November 1, 1999 - v1
Checksum:i5672BE2E07D9BC8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939120 Genomic DNA Translation: CAB44531.1
PIRiT34624
RefSeqiNP_628724.1, NC_003888.3
WP_003974383.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB44531; CAB44531; CAB44531
GeneIDi1100002
36124198
KEGGisco:SCO4562
PATRICifig|100226.15.peg.4634

Similar proteinsi

Entry informationi

Entry nameiQ9XAQ4_STRCO
AccessioniPrimary (citable) accession number: Q9XAQ4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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