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Q9XAQ2

- DEF3_STRCO

UniProt

Q9XAQ2 - DEF3_STRCO

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Protein

Peptide deformylase 3

Gene

def3

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).By similarity

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

Cofactori

Fe2+By similarityNote: Binds 1 Fe(2+) ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201IronBy similarity
Metal bindingi162 – 1621IronBy similarity
Active sitei163 – 1631By similarity
Metal bindingi166 – 1661IronBy similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 3 (EC:3.5.1.88)
Short name:
PDF 3
Alternative name(s):
Polypeptide deformylase 3
Gene namesi
Name:def3
Ordered Locus Names:SCO4560
ORF Names:SCD16A.23
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Peptide deformylase 3PRO_0000082854Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4560.

Structurei

3D structure databases

ProteinModelPortaliQ9XAQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.Curated

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
InParanoidiQ9XAQ2.
KOiK01462.
OMAiQLDGVFW.
OrthoDBiEOG664CMF.
PhylomeDBiQ9XAQ2.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XAQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSVFVQGRP TASYPPFAPE AGRGAVRRVT EVGEEVLHRP CRDVTEFGPD
60 70 80 90 100
LAALIDDMFR TMYVAEGAGL AANQVGVDLR LFVYDCPDDE GVRHVGHLVN
110 120 130 140 150
PVLDALDPAA RRLLDEGEGC LSVPGAVMAV PRPDRAVVRG LDKDGVPLLV
160 170 180 190 200
EGTGYFARCL AHETDHVNGH VYLDRLSGRE RKAALRQSAD RREEVFARRA

ANAAAFAA
Length:208
Mass (Da):22,514
Last modified:November 1, 1999 - v1
Checksum:iB72FB5E228BB844C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939120 Genomic DNA. Translation: CAB44533.1.
PIRiT34626.
RefSeqiNP_628722.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB44533; CAB44533; CAB44533.
GeneIDi1100000.
KEGGisco:SCO4560.
PATRICi23738936. VBIStrCoe124346_4632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939120 Genomic DNA. Translation: CAB44533.1 .
PIRi T34626.
RefSeqi NP_628722.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9XAQ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO4560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB44533 ; CAB44533 ; CAB44533 .
GeneIDi 1100000.
KEGGi sco:SCO4560.
PATRICi 23738936. VBIStrCoe124346_4632.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
InParanoidi Q9XAQ2.
KOi K01462.
OMAi QLDGVFW.
OrthoDBi EOG664CMF.
PhylomeDBi Q9XAQ2.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiDEF3_STRCO
AccessioniPrimary (citable) accession number: Q9XAQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3