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Q9XAQ2

- DEF3_STRCO

UniProt

Q9XAQ2 - DEF3_STRCO

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Protein
Peptide deformylase 3
Gene
def3, SCO4560, SCD16A.23
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Iron By similarity
Metal bindingi162 – 1621Iron By similarity
Active sitei163 – 1631 By similarity
Metal bindingi166 – 1661Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 3 (EC:3.5.1.88)
Short name:
PDF 3
Alternative name(s):
Polypeptide deformylase 3
Gene namesi
Name:def3
Ordered Locus Names:SCO4560
ORF Names:SCD16A.23
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Peptide deformylase 3UniRule annotation
PRO_0000082854Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4560.

Structurei

3D structure databases

ProteinModelPortaliQ9XAQ2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
KOiK01462.
OMAiQLDGVFW.
OrthoDBiEOG664CMF.
PhylomeDBiQ9XAQ2.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XAQ2-1 [UniParc]FASTAAdd to Basket

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MPSVFVQGRP TASYPPFAPE AGRGAVRRVT EVGEEVLHRP CRDVTEFGPD    50
LAALIDDMFR TMYVAEGAGL AANQVGVDLR LFVYDCPDDE GVRHVGHLVN 100
PVLDALDPAA RRLLDEGEGC LSVPGAVMAV PRPDRAVVRG LDKDGVPLLV 150
EGTGYFARCL AHETDHVNGH VYLDRLSGRE RKAALRQSAD RREEVFARRA 200
ANAAAFAA 208
Length:208
Mass (Da):22,514
Last modified:November 1, 1999 - v1
Checksum:iB72FB5E228BB844C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939120 Genomic DNA. Translation: CAB44533.1.
PIRiT34626.
RefSeqiNP_628722.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB44533; CAB44533; CAB44533.
GeneIDi1100000.
KEGGisco:SCO4560.
PATRICi23738936. VBIStrCoe124346_4632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939120 Genomic DNA. Translation: CAB44533.1 .
PIRi T34626.
RefSeqi NP_628722.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9XAQ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO4560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB44533 ; CAB44533 ; CAB44533 .
GeneIDi 1100000.
KEGGi sco:SCO4560.
PATRICi 23738936. VBIStrCoe124346_4632.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
KOi K01462.
OMAi QLDGVFW.
OrthoDBi EOG664CMF.
PhylomeDBi Q9XAQ2.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiDEF3_STRCO
AccessioniPrimary (citable) accession number: Q9XAQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi