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Q9XAQ2 (DEF3_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide deformylase 3

Short name=PDF 3
EC=3.5.1.88
Alternative name(s):
Polypeptide deformylase 3
Gene names
Name:def3
Ordered Locus Names:SCO4560
ORF Names:SCD16A.23
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP-Rule MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP-Rule MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP-Rule MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functioniron ion binding

Inferred from electronic annotation. Source: InterPro

peptide deformylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Peptide deformylase 3 HAMAP-Rule MF_00163
PRO_0000082854

Sites

Active site1631 By similarity
Metal binding1201Iron By similarity
Metal binding1621Iron By similarity
Metal binding1661Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XAQ2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B72FB5E228BB844C

FASTA20822,514
        10         20         30         40         50         60 
MPSVFVQGRP TASYPPFAPE AGRGAVRRVT EVGEEVLHRP CRDVTEFGPD LAALIDDMFR 

        70         80         90        100        110        120 
TMYVAEGAGL AANQVGVDLR LFVYDCPDDE GVRHVGHLVN PVLDALDPAA RRLLDEGEGC 

       130        140        150        160        170        180 
LSVPGAVMAV PRPDRAVVRG LDKDGVPLLV EGTGYFARCL AHETDHVNGH VYLDRLSGRE 

       190        200 
RKAALRQSAD RREEVFARRA ANAAAFAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939120 Genomic DNA. Translation: CAB44533.1.
PIRT34626.
RefSeqNP_628722.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9XAQ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO4560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB44533; CAB44533; CAB44533.
GeneID1100000.
KEGGsco:SCO4560.
PATRIC23738936. VBIStrCoe124346_4632.

Phylogenomic databases

eggNOGCOG0242.
HOGENOMHOG000243508.
KOK01462.
OMAQLDGVFW.
OrthoDBEOG664CMF.
PhylomeDBQ9XAQ2.

Family and domain databases

Gene3D3.90.45.10. 1 hit.
HAMAPMF_00163. Pep_deformylase.
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERPTHR10458. PTHR10458. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. SSF56420. 1 hit.
TIGRFAMsTIGR00079. pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDEF3_STRCO
AccessionPrimary (citable) accession number: Q9XAQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families