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Protein

Peptide deformylase 3

Gene

def3

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).By similarity

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi120IronBy similarity1
Metal bindingi162IronBy similarity1
Active sitei163By similarity1
Metal bindingi166IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 3 (EC:3.5.1.88)
Short name:
PDF 3
Alternative name(s):
Polypeptide deformylase 3
Gene namesi
Name:def3
Ordered Locus Names:SCO4560
ORF Names:SCD16A.23
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000828541 – 208Peptide deformylase 3Add BLAST208

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4560

Structurei

3D structure databases

ProteinModelPortaliQ9XAQ2
SMRiQ9XAQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.Curated

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243508
InParanoidiQ9XAQ2
KOiK01462
OMAiLIDDMFR
OrthoDBiPOG091H02B0
PhylomeDBiQ9XAQ2

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XAQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVFVQGRP TASYPPFAPE AGRGAVRRVT EVGEEVLHRP CRDVTEFGPD
60 70 80 90 100
LAALIDDMFR TMYVAEGAGL AANQVGVDLR LFVYDCPDDE GVRHVGHLVN
110 120 130 140 150
PVLDALDPAA RRLLDEGEGC LSVPGAVMAV PRPDRAVVRG LDKDGVPLLV
160 170 180 190 200
EGTGYFARCL AHETDHVNGH VYLDRLSGRE RKAALRQSAD RREEVFARRA

ANAAAFAA
Length:208
Mass (Da):22,514
Last modified:November 1, 1999 - v1
Checksum:iB72FB5E228BB844C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939120 Genomic DNA Translation: CAB44533.1
PIRiT34626
RefSeqiNP_628722.1, NC_003888.3
WP_003974385.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB44533; CAB44533; CAB44533
GeneIDi1100000
KEGGisco:SCO4560
PATRICifig|100226.15.peg.4632

Similar proteinsi

Entry informationi

Entry nameiDEF3_STRCO
AccessioniPrimary (citable) accession number: Q9XAQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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