Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9XAQ2

- DEF3_STRCO

UniProt

Q9XAQ2 - DEF3_STRCO

Protein

Peptide deformylase 3

Gene

def3

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.By similarity

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.

    Cofactori

    Binds 1 Fe2+ ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201IronBy similarity
    Metal bindingi162 – 1621IronBy similarity
    Active sitei163 – 1631By similarity
    Metal bindingi166 – 1661IronBy similarity

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase 3 (EC:3.5.1.88)
    Short name:
    PDF 3
    Alternative name(s):
    Polypeptide deformylase 3
    Gene namesi
    Name:def3
    Ordered Locus Names:SCO4560
    ORF Names:SCD16A.23
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Peptide deformylase 3PRO_0000082854Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO4560.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XAQ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243508.
    KOiK01462.
    OMAiQLDGVFW.
    OrthoDBiEOG664CMF.
    PhylomeDBiQ9XAQ2.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9XAQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSVFVQGRP TASYPPFAPE AGRGAVRRVT EVGEEVLHRP CRDVTEFGPD    50
    LAALIDDMFR TMYVAEGAGL AANQVGVDLR LFVYDCPDDE GVRHVGHLVN 100
    PVLDALDPAA RRLLDEGEGC LSVPGAVMAV PRPDRAVVRG LDKDGVPLLV 150
    EGTGYFARCL AHETDHVNGH VYLDRLSGRE RKAALRQSAD RREEVFARRA 200
    ANAAAFAA 208
    Length:208
    Mass (Da):22,514
    Last modified:November 1, 1999 - v1
    Checksum:iB72FB5E228BB844C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939120 Genomic DNA. Translation: CAB44533.1.
    PIRiT34626.
    RefSeqiNP_628722.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB44533; CAB44533; CAB44533.
    GeneIDi1100000.
    KEGGisco:SCO4560.
    PATRICi23738936. VBIStrCoe124346_4632.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939120 Genomic DNA. Translation: CAB44533.1 .
    PIRi T34626.
    RefSeqi NP_628722.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9XAQ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO4560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB44533 ; CAB44533 ; CAB44533 .
    GeneIDi 1100000.
    KEGGi sco:SCO4560.
    PATRICi 23738936. VBIStrCoe124346_4632.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243508.
    KOi K01462.
    OMAi QLDGVFW.
    OrthoDBi EOG664CMF.
    PhylomeDBi Q9XAQ2.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiDEF3_STRCO
    AccessioniPrimary (citable) accession number: Q9XAQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3