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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathway:ipentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (SCO0975)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:SCO1939
ORF Names:SCC22.21
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2612616-phosphogluconolactonasePRO_0000090106Add
BLAST

Proteomic databases

PRIDEiQ9XAB7.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1939.

Structurei

3D structure databases

ProteinModelPortaliQ9XAB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256283.
InParanoidiQ9XAB7.
KOiK01057.
OMAiHRDKELM.
OrthoDBiEOG63FW46.
PhylomeDBiQ9XAB7.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XAB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTPQLVVH RDKELMAEAA AARLITKIVD AQASRGSASV VLTGGRNGNG
60 70 80 90 100
LLAALAGSPA RDAIDWSRLD LWWGDERFLP EGDPERNVTQ AQQALLDSVP
110 120 130 140 150
LDPKRVHAMA ASDGPYGSDV EAAAAAYAQE LATASVPENH AAVPSFDVLL
160 170 180 190 200
LGVGPDTHVA SLFPEHPGVR ETERTVIGVH GSPKPPPIRI SLTLPAIRAA
210 220 230 240 250
REVWLLAAGE DKANAVAMAL SGAGEIQAPA AGARGRARTL WLLDSAAASQ
260
LPRSLYPPAS A
Length:261
Mass (Da):27,211
Last modified:November 1, 1999 - v1
Checksum:i7FE7741A0295AF91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939110 Genomic DNA. Translation: CAB50764.1.
PIRiT36011.
RefSeqiNP_626204.1. NC_003888.3.
WP_003976879.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB50764; CAB50764; CAB50764.
GeneIDi1097373.
KEGGisco:SCO1939.
PATRICi23733512. VBIStrCoe124346_1966.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939110 Genomic DNA. Translation: CAB50764.1.
PIRiT36011.
RefSeqiNP_626204.1. NC_003888.3.
WP_003976879.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9XAB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO1939.

Proteomic databases

PRIDEiQ9XAB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB50764; CAB50764; CAB50764.
GeneIDi1097373.
KEGGisco:SCO1939.
PATRICi23733512. VBIStrCoe124346_1966.

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256283.
InParanoidiQ9XAB7.
KOiK01057.
OMAiHRDKELM.
OrthoDBiEOG63FW46.
PhylomeDBiQ9XAB7.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry namei6PGL_STRCO
AccessioniPrimary (citable) accession number: Q9XAB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.