UniProtKB - Q9XAB7 (6PGL_STRCO)
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Protein
6-phosphogluconolactonase
Gene
pgl
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Functioni
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activityi
6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
: pentose phosphate pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
- 6-phosphogluconolactonase (pgl)
- 6-phosphogluconate dehydrogenase, decarboxylating (SCO0975)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
GO - Molecular functioni
- 6-phosphogluconolactonase activity Source: GO_Central
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- pentose-phosphate shunt, oxidative branch Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
UniPathwayi | UPA00115; UER00409. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pgl Synonyms:devB Ordered Locus Names:SCO1939 ORF Names:SCC22.21 |
Organismi | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) |
Taxonomic identifieri | 100226 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › Streptomyces albidoflavus group › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090106 | 1 – 261 | 6-phosphogluconolactonaseAdd BLAST | 261 |
Proteomic databases
PRIDEi | Q9XAB7. |
Structurei
3D structure databases
ProteinModelPortali | Q9XAB7. |
SMRi | Q9XAB7. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.Curated
Phylogenomic databases
eggNOGi | ENOG4107XU2. Bacteria. COG0363. LUCA. |
HOGENOMi | HOG000256283. |
InParanoidi | Q9XAB7. |
KOi | K01057. |
OMAi | KQPHLAI. |
OrthoDBi | POG091H04M8. |
PhylomeDBi | Q9XAB7. |
Family and domain databases
CDDi | cd01400. 6PGL. 1 hit. |
InterProi | View protein in InterPro IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase. IPR037171. NagB/RpiA_transferase-like. |
Pfami | View protein in Pfam PF01182. Glucosamine_iso. 1 hit. |
SUPFAMi | SSF100950. SSF100950. 1 hit. |
TIGRFAMsi | TIGR01198. pgl. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9XAB7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDTPQLVVH RDKELMAEAA AARLITKIVD AQASRGSASV VLTGGRNGNG
60 70 80 90 100
LLAALAGSPA RDAIDWSRLD LWWGDERFLP EGDPERNVTQ AQQALLDSVP
110 120 130 140 150
LDPKRVHAMA ASDGPYGSDV EAAAAAYAQE LATASVPENH AAVPSFDVLL
160 170 180 190 200
LGVGPDTHVA SLFPEHPGVR ETERTVIGVH GSPKPPPIRI SLTLPAIRAA
210 220 230 240 250
REVWLLAAGE DKANAVAMAL SGAGEIQAPA AGARGRARTL WLLDSAAASQ
260
LPRSLYPPAS A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL939110 Genomic DNA. Translation: CAB50764.1. |
PIRi | T36011. |
RefSeqi | NP_626204.1. NC_003888.3. WP_003976879.1. NC_003888.3. |
Genome annotation databases
EnsemblBacteriai | CAB50764; CAB50764; CAB50764. |
GeneIDi | 1097373. 29660507. |
KEGGi | sco:SCO1939. |
PATRICi | fig|100226.15.peg.1966. |
Similar proteinsi
Entry informationi
Entry namei | 6PGL_STRCO | |
Accessioni | Q9XAB7Primary (citable) accession number: Q9XAB7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | November 22, 2017 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |