pgl

Functionⁱ

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityⁱ

6-phospho-D-glucono-1,5-lactone + H₂O = 6-phospho-D-gluconate.

Pathwayⁱ: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
6-phosphogluconolactonase (pgl)
6-phosphogluconate dehydrogenase, decarboxylating (SCO0975)

This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Enzyme and pathway databases

UniPathwayⁱ	UPA00115; UER00409.

UniPathwayⁱ

UPA00115; UER00409.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 6-phosphogluconolactonase (EC:3.1.1.31) Short name: 6PGL
Gene namesⁱ	Name:pgl Synonyms:devB Ordered Locus Names:SCO1939 ORF Names:SCC22.21
Organismⁱ	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifierⁱ	100226 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › Streptomyces albidoflavus group › Streptomyces coelicolor
Proteomesⁱ	UP000001973 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 261	261	6-phosphogluconolactonase		PRO_0000090106	Add BLAST

Proteomic databases

PRIDEⁱ	Q9XAB7.

PRIDEⁱ

Q9XAB7.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	100226.SCO1939.

STRINGⁱ

100226.SCO1939.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9XAB7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4107XU2. Bacteria. COG0363. LUCA.
HOGENOMⁱ	HOG000256283.
InParanoidⁱ	Q9XAB7.
KOⁱ	K01057.
OMAⁱ	DRNAKQA.
OrthoDBⁱ	POG091H04M8.
PhylomeDBⁱ	Q9XAB7.

Family and domain databases

InterProⁱ	IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
Pfamⁱ	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMsⁱ	TIGR01198. pgl. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9XAB7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDTPQLVVH RDKELMAEAA AARLITKIVD AQASRGSASV VLTGGRNGNG 
        60         70         80         90        100
LLAALAGSPA RDAIDWSRLD LWWGDERFLP EGDPERNVTQ AQQALLDSVP 
       110        120        130        140        150
LDPKRVHAMA ASDGPYGSDV EAAAAAYAQE LATASVPENH AAVPSFDVLL 
       160        170        180        190        200
LGVGPDTHVA SLFPEHPGVR ETERTVIGVH GSPKPPPIRI SLTLPAIRAA 
       210        220        230        240        250
REVWLLAAGE DKANAVAMAL SGAGEIQAPA AGARGRARTL WLLDSAAASQ 
       260 
LPRSLYPPAS A

Length:261

Mass (Da):27,211

Last modified:November 1, 1999 - v1

Checksum:ⁱ7FE7741A0295AF91

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL939110 Genomic DNA. Translation: CAB50764.1.
PIRⁱ	T36011.
RefSeqⁱ	NP_626204.1. NC_003888.3. WP_003976879.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaⁱ	CAB50764; CAB50764; CAB50764.
GeneIDⁱ	1097373.
KEGGⁱ	sco:SCO1939.
PATRICⁱ	23733512. VBIStrCoe124346_1966.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL939110 Genomic DNA. Translation: CAB50764.1.
PIRⁱ	T36011.
RefSeqⁱ	NP_626204.1. NC_003888.3. WP_003976879.1. NC_003888.3.

3D structure databases

ProteinModelPortalⁱ	Q9XAB7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	100226.SCO1939.

STRINGⁱ

100226.SCO1939.

Proteomic databases

PRIDEⁱ	Q9XAB7.

PRIDEⁱ

Q9XAB7.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAB50764; CAB50764; CAB50764.
GeneIDⁱ	1097373.
KEGGⁱ	sco:SCO1939.
PATRICⁱ	23733512. VBIStrCoe124346_1966.

Phylogenomic databases

eggNOGⁱ	ENOG4107XU2. Bacteria. COG0363. LUCA.
HOGENOMⁱ	HOG000256283.
InParanoidⁱ	Q9XAB7.
KOⁱ	K01057.
OMAⁱ	DRNAKQA.
OrthoDBⁱ	POG091H04M8.
PhylomeDBⁱ	Q9XAB7.

Enzyme and pathway databases

UniPathwayⁱ	UPA00115; UER00409.

UniPathwayⁱ

UPA00115; UER00409.

Family and domain databases

InterProⁱ	IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
Pfamⁱ	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMsⁱ	TIGR01198. pgl. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

6PGL_STRCO

Accessionⁱ

Primary (citable) accession number: Q9XAB7

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9XAB7 (6PGL_STRCO)

UniProt

Q9XAB7 - 6PGL_STRCO

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6-phosphogluconolactonase

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>Describes the metabolic pathway(s) associated with a protein.</p><p><a href='../manual/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: pentose phosphate pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ