pgl

Functionⁱ

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityⁱ

6-phospho-D-glucono-1,5-lactone + H₂O = 6-phospho-D-gluconate.

Pathwayⁱ: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
6-phosphogluconolactonase (pgl)
6-phosphogluconate dehydrogenase, decarboxylating (SCO0975)

This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functionⁱ

6-phosphogluconolactonase activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
pentose-phosphate shunt, oxidative branch Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Enzyme and pathway databases

UniPathwayⁱ	UPA00115; UER00409.

UniPathwayⁱ

UPA00115; UER00409.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 6-phosphogluconolactonase (EC:3.1.1.31) Short name: 6PGL
Gene namesⁱ	Name:pgl Synonyms:devB Ordered Locus Names:SCO1939 ORF Names:SCC22.21
Organismⁱ	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifierⁱ	100226 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › Streptomyces albidoflavus group › Streptomyces coelicolor
Proteomesⁱ	UP000001973 Componentⁱ: Chromosome

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: GO_Central

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000090106	1 – 261	6-phosphogluconolactonaseAdd BLAST		261

Proteomic databases

PRIDEⁱ	Q9XAB7.

PRIDEⁱ

Q9XAB7.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	100226.SCO1939.

STRINGⁱ

100226.SCO1939.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9XAB7.
SMRⁱ	Q9XAB7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4107XU2. Bacteria. COG0363. LUCA.
HOGENOMⁱ	HOG000256283.
InParanoidⁱ	Q9XAB7.
KEGG Orthology (KO) More...KOⁱ	K01057.
OMAⁱ	KQPHLAI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H04M8.
PhylomeDBⁱ	Q9XAB7.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01400. 6PGL. 1 hit.
InterProⁱ	View protein in InterPro IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01182. Glucosamine_iso. 1 hit.
TIGRFAMsⁱ	TIGR01198. pgl. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9XAB7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDTPQLVVH RDKELMAEAA AARLITKIVD AQASRGSASV VLTGGRNGNG 
        60         70         80         90        100
LLAALAGSPA RDAIDWSRLD LWWGDERFLP EGDPERNVTQ AQQALLDSVP 
       110        120        130        140        150
LDPKRVHAMA ASDGPYGSDV EAAAAAYAQE LATASVPENH AAVPSFDVLL 
       160        170        180        190        200
LGVGPDTHVA SLFPEHPGVR ETERTVIGVH GSPKPPPIRI SLTLPAIRAA 
       210        220        230        240        250
REVWLLAAGE DKANAVAMAL SGAGEIQAPA AGARGRARTL WLLDSAAASQ 
       260 
LPRSLYPPAS A

Length:261

Mass (Da):27,211

Last modified:November 1, 1999 - v1

Checksum:ⁱ7FE7741A0295AF91

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL939110 Genomic DNA. Translation: CAB50764.1.
PIRⁱ	T36011.
NCBI Reference Sequences More...RefSeqⁱ	NP_626204.1. NC_003888.3. WP_003976879.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaⁱ	CAB50764; CAB50764; CAB50764.
GeneIDⁱ	1097373. 29660507.
KEGGⁱ	sco:SCO1939.
PATRICⁱ	fig\|100226.15.peg.1966.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9XAB7	A0A1H1Y4E0 D6EKH9	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) Streptomyces sp. 2114.2 Streptomyces lividans TK24	261	UniRef100_Q9XAB7	Cluster: 6-phosphogluconolactonase	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9XAB7	A0A1H1Y4E0 D6EKH9 A0A0M8YY51 H1QPD3 A0A0N6ZPZ3 A0A1R1WRT1 A0A0N0Y7I2 UPI0004C1B3FC UPI0004C93C88 UPI0004CA2176 +13	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) Streptomyces sp. 2114.2 Streptomyces lividans TK24 Streptomyces sp. NRRL F-7442 Streptomyces coelicoflavus ZG0656 Streptomyces sp. CCM_MD2014 Streptomyces sp. M1013 Streptomyces sp. NRRL WC-3753 Streptomyces violaceorubidus Streptomyces sp. NRRL F-5650 And more	261	UniRef90_Q9XAB7	Cluster: 6-phosphogluconolactonase	24

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9XAB7	A0A1H1Y4E0 D6EKH9 H1QPD3 A0A0N6ZPZ3 UPI0004C1B3FC UPI0004CA2176 UPI000B41EF93 UPI00069A8786 A0A0M8YY51 A0A0N0Y7I2 +755	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) Streptomyces sp. 2114.2 Streptomyces lividans TK24 Streptomyces coelicoflavus ZG0656 Streptomyces sp. CCM_MD2014 Streptomyces violaceorubidus Streptomyces violaceoruber Streptomyces sp. CS113 Streptomyces aureofaciens Streptomyces sp. NRRL F-7442 And more	261	UniRef50_Q9XAB7	Cluster: 6-phosphogluconolactonase	766

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL939110 Genomic DNA. Translation: CAB50764.1.
PIRⁱ	T36011.
NCBI Reference Sequences More...RefSeqⁱ	NP_626204.1. NC_003888.3. WP_003976879.1. NC_003888.3.

3D structure databases

ProteinModelPortalⁱ	Q9XAB7.
SMRⁱ	Q9XAB7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	100226.SCO1939.

STRINGⁱ

100226.SCO1939.

Proteomic databases

PRIDEⁱ	Q9XAB7.

PRIDEⁱ

Q9XAB7.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAB50764; CAB50764; CAB50764.
GeneIDⁱ	1097373. 29660507.
KEGGⁱ	sco:SCO1939.
PATRICⁱ	fig\|100226.15.peg.1966.

Phylogenomic databases

eggNOGⁱ	ENOG4107XU2. Bacteria. COG0363. LUCA.
HOGENOMⁱ	HOG000256283.
InParanoidⁱ	Q9XAB7.
KEGG Orthology (KO) More...KOⁱ	K01057.
OMAⁱ	KQPHLAI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H04M8.
PhylomeDBⁱ	Q9XAB7.

Enzyme and pathway databases

UniPathwayⁱ	UPA00115; UER00409.

UniPathwayⁱ

UPA00115; UER00409.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01400. 6PGL. 1 hit.
InterProⁱ	View protein in InterPro IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01182. Glucosamine_iso. 1 hit.
TIGRFAMsⁱ	TIGR01198. pgl. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	6PGL_STRCO
Accessionⁱ	Q9XAB7Primary (citable) accession number: Q9XAB7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1999
	Last modified:	June 7, 2017
	This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9XAB7 (6PGL_STRCO)

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6-phosphogluconolactonase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: pentose phosphate pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ