Q9X992 (Q9X992_9ACTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
PimS0 protein EMBL CAC20930.1

Submitted name:
Polyketide synthase EMBL CAB41040.1

Gene names

Name:

pimS0 EMBL CAB41040.1

Organism

Streptomyces natalensis EMBL CAB41040.1

Taxonomic identifier

68242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	1847 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9X992 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: F61AE9AADD6FC1F9	FASTA	1,847	193,383
	10 20 30 40 50 60 MVPVHTDDYA IQPPADTAHG GGGFTLPAVF EAAVESAPDA VALVDGTVPG PGRMWRADVD 70 80 90 100 110 120 ALARGLQESG IAPGDVVAVR LPNCGRFPTL HLAVAAVGAV LLPIHQGTPL PEVDALLTRA 130 140 150 160 170 180 EPALLVLSAA GSDGLATARS LLESVPSLRG VLLAGASGDG ESGSVGGGES GSGRRSLDGL 190 200 210 220 230 240 LAGWAGSGPR PVDVTPDMPL VLVPSSGTVS ARPKLCVHSH DGLLSNTAAV TAEAADAFDG 250 260 270 280 290 300 PVLTACPMTH LFGLQSLHAA LFAACTQVLL TGWDVDRFLE QAREHGPRVV FAVPAQLRDV 310 320 330 340 350 360 VTRLARTGEP AGFTPYQVRT AGAAVAPALA VRVRAVLDCE LVVVWGMSEI GTGTRTRAHH 370 380 390 400 410 420 PDGCVGEPVS GVDVRVVDEH GQECAADERG ELQYRGPGLF RGYFREPELT RSALTDDGWL 430 440 450 460 470 480 RTGDLATVDA DGVVVLHGRA AELINTGGRK FSAGEVEGLL SGFTDLGPLA VVGAPDDRLG 490 500 510 520 530 540 EYPCLVVTDH ADGTIGLSEV TAFLRRLGLA DHKIPLELVT VRELPFSPAG KLDRGALKRL 550 560 570 580 590 600 LANLAEVSVP ARLGAVPPYT AEEALDLVRD CVGRVLRYGG AAVPFPPDKD FFSPDKDFRQ 610 620 630 640 650 660 LGLDSIGAVR LRNLLREETG LPLPATLAFD SPTPRAVARV LAEQEEPSQD EPRENPADGA 670 680 690 700 710 720 DPVAIVGMAC RLPGGADSPD ALWELLADGT DAMSPFPTDR GWDLDRLFDE DADRPGTSYA 730 740 750 760 770 780 REGGFLHDAG DFDAGFFGLS DQEATATDPQ QRLLLEAAWE TFERAGIDPQ SLRGSRTGVF 790 800 810 820 830 840 TGAMDRGYGT SASAAPSAWE SMLITGTAGS AVSGRIAYTY GLEGPALTVD TASSSSLVAL 850 860 870 880 890 900 HLACRSLRSG ETDLALAGGV TVMATPAPFA HFSRLRALSP DSRSMAYADA ANGSAWSEGA 910 920 930 940 950 960 GLLLLERLSD ARRNGHRVLA LVRGSAVNQD GASNGLTAPS GPAQQRVIRQ ALADAGLTPQ 970 980 990 1000 1010 1020 DVDAVEGHGT GTPLGDPIEA QALLATYGQQ RPVERPLWLG SVKSNFGHTQ AAAGVVGVIK 1030 1040 1050 1060 1070 1080 TVLALRHGVL PQTLHVDAPS AKVDWSAGSV RLLTEARPWP RESGRTRRAG VSSFGLTGTN 1090 1100 1110 1120 1130 1140 AHVILEEAPG EAAAGARAEV PEEARCASSP ARLPEPPGDA AAPWVLSARS RAALRAQALR 1150 1160 1170 1180 1190 1200 LADQVAADPG LRAQDVAHAL ATSRTLHRHR AVVSGSDRAQ MLAAAKRFGL GERTAGVTPD 1210 1220 1230 1240 1250 1260 DSAPGLLAFV FSGQGSQRSG MGRAAAEAFP VFGRALGEVC AALDPLLTRP LTSVMWAAPG 1270 1280 1290 1300 1310 1320 SEEAARLDDT TYTQPALFAV QVALYRLFES WGVVPDQLVG HSVGEISAAH VAGVLGLRDA 1330 1340 1350 1360 1370 1380 CTLVAARSRL MGALPPGGAM VAVRITEPEV TPWLAELTDE VSIAAVNGPH SLVLAGAEAP 1390 1400 1410 1420 1430 1440 LVALTDRLAA AGHKTRRLMV STAPHSPLMD PMLEEFRAVV RTLSYAAPAV PLVSTVTGRP 1450 1460 1470 1480 1490 1500 LTGEEARDPD HWVRHVRQSV RFKDAIGRLR DERVTGFLEL GAEPALTPMI DECLESADGQ 1510 1520 1530 1540 1550 1560 PGTALVPSLR AGVPERDALL TAVARVHAQG VPVDWDAVLP GAEASVTVRG LPAADRQWFR 1570 1580 1590 1600 1610 1620 FVPDQGAPLT LADRSLHLEG AAHLRDVGGC RTADGRWVKM GVLYRTNNLH ALTDADLAKL 1630 1640 1650 1660 1670 1680 QRLGIRTDFD LRMPGERAKA PNRVPTGARY IVADAFDAHL RDGLSLSERD LERLREARLS 1690 1700 1710 1720 1730 1740 GLDEAEQHAL VLALVLAETS AVLGGQETPG EEPHGEEGHR TFKEMGINSL NAVELRNRLI 1750 1760 1770 1780 1790 1800 AATDLRLPAT LVYDYPTPKA VVRLVRERLA RPASPARDVA SVVAELESLL TAGAEVSEET 1810 1820 1830 1840 AARLKAVTAV STGTTGSGSG TGAGSGGALD LVSASDEELF RLMDAES

References

[1]	"A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis." Aparicio J.F., Fouces R., Mendes M.V., Olivera N., Martin J.F. Chem. Biol. 7:895-905(2000) [PubMed: 11094342] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes." Aparicio J.F., Colina A.J., Ceballos E., Martin J.F. J. Biol. Chem. 274:10133-10139(1999) [PubMed: 10187796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ132221 Genomic DNA. Translation: CAB41040.1. AJ278573 Genomic DNA. Translation: CAC20930.1.
3D structure databases
HSSP	HSSP built from PDB template 1LCI based on UniProtKB P08659.
ProteinModelPortal	Q9X992.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR000873. AMP-dep_Synth/Lig. IPR000794. Beta-ketoacyl_synthase. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR006163. Phsphopanteth-bd. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020806. PKS_PP-bd. IPR006162. PPantetheine_attach_site. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 2 hits. G3DSA:1.10.1200.10. ACP_like. 2 hits. G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00698. Acyl_transf_1. 1 hit. PF00501. AMP-binding. 1 hit. PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. PF00550. PP-binding. 2 hits. [Graphical view]
SMART	SM00827. PKS_AT. 1 hit. SM00825. PKS_KS. 1 hit. SM00823. PKS_PP. 2 hits. [Graphical view]
SUPFAM	SSF47336. ACP_like. 2 hits. SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit. SSF53901. Thiolase-like. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 2 hits. PS00012. PHOSPHOPANTETHEINE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9X992_9ACTO

Accession

Primary (citable) accession number: Q9X992

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)