Q9X928 (ACSA_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	SCO3563
ORF Names:	SCH5.26

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	651 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 651	651	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_0000208389
Sites
	Active site	518	1	By similarity
Amino acid modifications
	Modified residue	610	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9X928 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 3A04CFD3ED436EC5	FASTA	651	71,045
	10 20 30 40 50 60 MSNESLANLL KEERRFAPPA DLAANANVTA EAYEQAKADR LGFWAEQARR LTWAKEPTET 70 80 90 100 110 120 LDWSNPPFAK WFKDGTLNVA YNCVDRHVEA GNGDRVAIHF EGESGDSRAL TYAQLKDEVS 130 140 150 160 170 180 KAANALLELG VQKGDRVAIY MPMIPETAIA MLACARIGAA HSVVFGGFSS DALATRIQDA 190 200 210 220 230 240 DARVVITADG GYRRGKPSAL KPAVDEAVER AGIVEHVLVV RRTGQDVAWD DSRDKWWHET 250 260 270 280 290 300 VDGQSAEHTP EAFDAEHPLF ILYTSGTTGK PKGILHTSGG YLTQTAYTHW AVFDLKPETD 310 320 330 340 350 360 VFWCTADVGW VTGHSYIVYG PLANGATQVM YEGTPDTPHQ GRFWEIVQKY GVTILYTAPT 370 380 390 400 410 420 AIRTFMKWGD DIPAKFDLSS LRVLGSVGEP INPEAWIWYR KNIGADATPV VDTWWQTETG 430 440 450 460 470 480 AMMITPLPGV THAKPGSAQR PLPGISATVV DDEANEVPNG GGGYLVLTEP WPSMLRTIWG 490 500 510 520 530 540 DDQRFIDTYW SRFEGKYFAG DGAKKDDDGD IWLLGRVDDV MLVSGHNIST TEVESALVSH 550 560 570 580 590 600 PSVAEAAVVG ATDETTGQAI VAFVILRGTT AESEDLVAEL RNHVGATLGP IAKPKRILPV 610 620 630 640 650 SELPKTRSGK IMRRLLRDVA ENRQVGDVTT LADSTVMDLI QTKLPAAPSE D

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939117 Genomic DNA. Translation: CAB38500.1.
PIR	T36684.
RefSeq	NP_627761.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9X928.
SMR	Q9X928. Positions 15-643.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1098999.
GenomeReviews	Gene locus SCO3563 in contig AL645882_GR.
KEGG	sco:SCO3563.
NMPDR	fig|100226.1.peg.3520.
PATRIC	23736870. VBIStrCoe124346_3619.
Phylogenomic databases
HOGENOM	HBG547964.
OMA	TRGTEES.
PhylomeDB	Q9X928.
ProtClustDB	PRK00174.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_STRCO

Accession

Primary (citable) accession number: Q9X928

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program