Reviewed,
UniProtKB/Swiss-Prot Q9X913 (HPPA_STRCO)
Last modified
February 9, 2010.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Pyrophosphate-energized proton pump EC=3.6.1.1 Alternative name(s): Pyrophosphate-energized inorganic pyrophosphatase Short name=H(+)-PPase Membrane-bound proton-translocating pyrophosphatase | ||||||
| Gene names |
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| Organism | Streptomyces coelicolor [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1902 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces |
Protein attributes
| Sequence length | 794 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Generates a proton motive force; it probably catalyzes a fully reversible reaction, thus being able to synthesize pyrophosphate when the proton motive force is sufficient By similarity. HAMAP MF_01130 |
| Catalytic activity | Diphosphate + H2O = 2 phosphate. HAMAP MF_01130 |
| Cofactor | Magnesium By similarity. HAMAP MF_01130 |
| Subunit structure | Homodimer Potential. HAMAP MF_01130 |
| Subcellular location | Cell membrane; Multi-pass membrane protein Probable HAMAP MF_01130. |
| Sequence similarities | Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. Type 2 subfamily. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Hydrogen ion transport Ion transport Transport |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Ligand | Magnesium |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proton transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: HAMAP |
| Molecular function | hydrogen-translocating pyrophosphatase activity Inferred from electronic annotation. Source: InterPro inorganic diphosphatase activityInferred from electronic annotation. Source: HAMAP magnesium ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 794 | 794 | Pyrophosphate-energized proton pump HAMAP MF_01130 | PRO_0000217032 | |||||
Regions | |||||||||
| Transmembrane | 20 – 39 | 20 | Potential | ||||||
| Transmembrane | 74 – 91 | 18 | Potential | ||||||
| Transmembrane | 101 – 123 | 23 | Potential | ||||||
| Transmembrane | 164 – 186 | 23 | Potential | ||||||
| Transmembrane | 191 – 213 | 23 | Potential | ||||||
| Transmembrane | 260 – 279 | 20 | Potential | ||||||
| Transmembrane | 284 – 306 | 23 | Potential | ||||||
| Transmembrane | 319 – 341 | 23 | Potential | ||||||
| Transmembrane | 365 – 387 | 23 | Potential | ||||||
| Transmembrane | 408 – 430 | 23 | Potential | ||||||
| Transmembrane | 445 – 467 | 23 | Potential | ||||||
| Transmembrane | 512 – 534 | 23 | Potential | ||||||
| Transmembrane | 563 – 585 | 23 | Potential | ||||||
| Transmembrane | 629 – 651 | 23 | Potential | ||||||
| Transmembrane | 655 – 677 | 23 | Potential | ||||||
| Transmembrane | 715 – 737 | 23 | Potential | ||||||
| Transmembrane | 747 – 766 | 20 | Potential | ||||||
Sites | |||||||||
| Site | 507 | 1 | Determinant of potassium independence By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. Hopwood D.A.Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL939117 Genomic DNA. Translation: CAB38484.1. |
| PIR | T36668. |
| RefSeq | NP_627745.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1098983. |
| KEGG | sco:SCO3547. |
| NMPDR | fig|100226.1.peg.3504. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG593668. |
| OMA | AYLARQY. |
Enzyme and pathway databases | |
| BioCyc | SCOE100226:SCO3547-MONOMER. |
| BRENDA | 3.6.1.1. 1084. |
Family and domain databases | |
| HAMAP | MF_01130. H_PPase_type2. [Tree] |
| InterPro | IPR004131. H_PPase. [Graphical view] |
| Pfam | PF03030. H_PPase. 1 hit. [Graphical view] |
| PIRSF | PIRSF001265. H+-PPase. 1 hit. |
| TIGRFAMs | TIGR01104. V_PPase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HPPA_STRCO | ||||||||
| Accession | Primary (citable) accession number: Q9X913 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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