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Q9X8R6

- ALF_STRCO

UniProt

Q9X8R6 - ALF_STRCO

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Protein
Fructose-bisphosphate aldolase
Gene
fba, SCO3649, SCH10.27c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Glyceraldehyde 3-phosphate By similarity
Active sitei95 – 951Proton donor By similarity
Metal bindingi96 – 961Zinc 1; catalytic By similarity
Metal bindingi131 – 1311Zinc 2 By similarity
Metal bindingi161 – 1611Zinc 2 By similarity
Metal bindingi212 – 2121Zinc 1; catalytic By similarity
Binding sitei213 – 2131Dihydroxyacetone phosphate; via amide nitrogen By similarity
Metal bindingi252 – 2521Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:SCO3649
ORF Names:SCH10.27c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Fructose-bisphosphate aldolase
PRO_0000178743Add
BLAST

Proteomic databases

PRIDEiQ9X8R6.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3649.

Structurei

3D structure databases

ProteinModelPortaliQ9X8R6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni253 – 2553Dihydroxyacetone phosphate binding By similarity
Regioni274 – 2774Dihydroxyacetone phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227794.
KOiK01624.
OMAiHNSLDFV.
OrthoDBiEOG69GZPB.
PhylomeDBiQ9X8R6.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X8R6-1 [UniParc]FASTAAdd to Basket

« Hide

MPIATPEVYN EMLDRAKAGK FAYPAINVTS SQTLHAALRG FAEAESDGIV    50
QISTGGAEFL GGQHNKDMVT GAVALAEFAH IVAEKYDVTV ALHTDHCPKD 100
KLDGYVRPLI AVSEERVKAG RNPLFQSHMW DGSAETLADN LSIAQELLAR 150
ARAARIILEV EITPTGGEED GVSHEINDSL YTTVDDAVRT VEALGLGEKG 200
RYLLAASFGN VHGVYKPGNV VLRPELLKEL NEGIASKYGQ PAGSKPFDFV 250
FHGGSGSTAE EIATALENGV VKMNIDTDTQ YAFTRPVVDH MFRNYDGVLK 300
VDGEVGNKKT YDPRTWGKLA EAGMAARVVE ACGHLRSAGQ KIK 343
Length:343
Mass (Da):36,927
Last modified:November 1, 1999 - v1
Checksum:iA1E2BE768028CE2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939117 Genomic DNA. Translation: CAB42036.1.
PIRiT36539.
RefSeqiNP_627843.1. NC_003888.3.
WP_011029142.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42036; CAB42036; CAB42036.
GeneIDi1099085.
KEGGisco:SCO3649.
PATRICi23737052. VBIStrCoe124346_3709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939117 Genomic DNA. Translation: CAB42036.1 .
PIRi T36539.
RefSeqi NP_627843.1. NC_003888.3.
WP_011029142.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9X8R6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 100226.SCO3649.

Proteomic databases

PRIDEi Q9X8R6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB42036 ; CAB42036 ; CAB42036 .
GeneIDi 1099085.
KEGGi sco:SCO3649.
PATRICi 23737052. VBIStrCoe124346_3709.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227794.
KOi K01624.
OMAi HNSLDFV.
OrthoDBi EOG69GZPB.
PhylomeDBi Q9X8R6.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiALF_STRCO
AccessioniPrimary (citable) accession number: Q9X8R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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