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Q9X8R6

- ALF_STRCO

UniProt

Q9X8R6 - ALF_STRCO

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Glyceraldehyde 3-phosphateBy similarity
Active sitei95 – 951Proton donorBy similarity
Metal bindingi96 – 961Zinc 1; catalyticBy similarity
Metal bindingi131 – 1311Zinc 2By similarity
Metal bindingi161 – 1611Zinc 2By similarity
Metal bindingi212 – 2121Zinc 1; catalyticBy similarity
Binding sitei213 – 2131Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi252 – 2521Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:SCO3649
ORF Names:SCH10.27c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Fructose-bisphosphate aldolasePRO_0000178743Add
BLAST

Proteomic databases

PRIDEiQ9X8R6.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3649.

Structurei

3D structure databases

ProteinModelPortaliQ9X8R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni253 – 2553Dihydroxyacetone phosphate bindingBy similarity
Regioni274 – 2774Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227794.
InParanoidiQ9X8R6.
KOiK01624.
OMAiHNSLDFV.
OrthoDBiEOG69GZPB.
PhylomeDBiQ9X8R6.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X8R6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPIATPEVYN EMLDRAKAGK FAYPAINVTS SQTLHAALRG FAEAESDGIV
60 70 80 90 100
QISTGGAEFL GGQHNKDMVT GAVALAEFAH IVAEKYDVTV ALHTDHCPKD
110 120 130 140 150
KLDGYVRPLI AVSEERVKAG RNPLFQSHMW DGSAETLADN LSIAQELLAR
160 170 180 190 200
ARAARIILEV EITPTGGEED GVSHEINDSL YTTVDDAVRT VEALGLGEKG
210 220 230 240 250
RYLLAASFGN VHGVYKPGNV VLRPELLKEL NEGIASKYGQ PAGSKPFDFV
260 270 280 290 300
FHGGSGSTAE EIATALENGV VKMNIDTDTQ YAFTRPVVDH MFRNYDGVLK
310 320 330 340
VDGEVGNKKT YDPRTWGKLA EAGMAARVVE ACGHLRSAGQ KIK
Length:343
Mass (Da):36,927
Last modified:November 1, 1999 - v1
Checksum:iA1E2BE768028CE2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939117 Genomic DNA. Translation: CAB42036.1.
PIRiT36539.
RefSeqiNP_627843.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42036; CAB42036; CAB42036.
GeneIDi1099085.
KEGGisco:SCO3649.
PATRICi23737052. VBIStrCoe124346_3709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939117 Genomic DNA. Translation: CAB42036.1 .
PIRi T36539.
RefSeqi NP_627843.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9X8R6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO3649.

Proteomic databases

PRIDEi Q9X8R6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB42036 ; CAB42036 ; CAB42036 .
GeneIDi 1099085.
KEGGi sco:SCO3649.
PATRICi 23737052. VBIStrCoe124346_3709.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227794.
InParanoidi Q9X8R6.
KOi K01624.
OMAi HNSLDFV.
OrthoDBi EOG69GZPB.
PhylomeDBi Q9X8R6.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiALF_STRCO
AccessioniPrimary (citable) accession number: Q9X8R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3