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Q9X8R6

- ALF_STRCO

UniProt

Q9X8R6 - ALF_STRCO

Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531Glyceraldehyde 3-phosphateBy similarity
    Active sitei95 – 951Proton donorBy similarity
    Metal bindingi96 – 961Zinc 1; catalyticBy similarity
    Metal bindingi131 – 1311Zinc 2By similarity
    Metal bindingi161 – 1611Zinc 2By similarity
    Metal bindingi212 – 2121Zinc 1; catalyticBy similarity
    Binding sitei213 – 2131Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi252 – 2521Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Gene namesi
    Name:fba
    Ordered Locus Names:SCO3649
    ORF Names:SCH10.27c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Fructose-bisphosphate aldolasePRO_0000178743Add
    BLAST

    Proteomic databases

    PRIDEiQ9X8R6.

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO3649.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9X8R6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni253 – 2553Dihydroxyacetone phosphate bindingBy similarity
    Regioni274 – 2774Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    HOGENOMiHOG000227794.
    KOiK01624.
    OMAiHNSLDFV.
    OrthoDBiEOG69GZPB.
    PhylomeDBiQ9X8R6.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X8R6-1 [UniParc]FASTAAdd to Basket

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    MPIATPEVYN EMLDRAKAGK FAYPAINVTS SQTLHAALRG FAEAESDGIV    50
    QISTGGAEFL GGQHNKDMVT GAVALAEFAH IVAEKYDVTV ALHTDHCPKD 100
    KLDGYVRPLI AVSEERVKAG RNPLFQSHMW DGSAETLADN LSIAQELLAR 150
    ARAARIILEV EITPTGGEED GVSHEINDSL YTTVDDAVRT VEALGLGEKG 200
    RYLLAASFGN VHGVYKPGNV VLRPELLKEL NEGIASKYGQ PAGSKPFDFV 250
    FHGGSGSTAE EIATALENGV VKMNIDTDTQ YAFTRPVVDH MFRNYDGVLK 300
    VDGEVGNKKT YDPRTWGKLA EAGMAARVVE ACGHLRSAGQ KIK 343
    Length:343
    Mass (Da):36,927
    Last modified:November 1, 1999 - v1
    Checksum:iA1E2BE768028CE2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939117 Genomic DNA. Translation: CAB42036.1.
    PIRiT36539.
    RefSeqiNP_627843.1. NC_003888.3.
    WP_011029142.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB42036; CAB42036; CAB42036.
    GeneIDi1099085.
    KEGGisco:SCO3649.
    PATRICi23737052. VBIStrCoe124346_3709.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939117 Genomic DNA. Translation: CAB42036.1 .
    PIRi T36539.
    RefSeqi NP_627843.1. NC_003888.3.
    WP_011029142.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9X8R6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO3649.

    Proteomic databases

    PRIDEi Q9X8R6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB42036 ; CAB42036 ; CAB42036 .
    GeneIDi 1099085.
    KEGGi sco:SCO3649.
    PATRICi 23737052. VBIStrCoe124346_3709.

    Phylogenomic databases

    eggNOGi COG0191.
    HOGENOMi HOG000227794.
    KOi K01624.
    OMAi HNSLDFV.
    OrthoDBi EOG69GZPB.
    PhylomeDBi Q9X8R6.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiALF_STRCO
    AccessioniPrimary (citable) accession number: Q9X8R6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3