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Reviewed, UniProtKB/Swiss-Prot Q9X8N8 (NADB_STRCO)

Last modified November 3, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-aspartate oxidase
      Short name=LASPO
    EC=1.4.3.16
Alternative name(s):
    Quinolinate synthetase B
Gene names
Name: nadB
Ordered Locus Names: SCO3382
ORF Names: SCE94.33c
OrganismStreptomyces coelicolor [Complete proteome] [HAMAP]
Taxonomic identifier1902 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

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Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activity

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactor

FAD.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

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Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-aspartate oxidase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580L-aspartate oxidase
PRO_0000184401

Regions

Nucleotide binding22 – 3615FAD Potential

Sites

Active site2481 By similarity
Active site2701 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9X8N8-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: CA8E4026CC1AF7D4

FASTA58061,274
        10         20         30         40         50         60 
MTSTGIRLHA PAPGWAIAAD VVVVGSGVAG LTAALRCESA GLRTVVVTKA RLDDGSTRWA 

        70         80         90        100        110        120 
QGGVAAALGE GDTPEQHLDD TLVAGAGLCD QDAVRILVTE GPDAVRRLIA TGAHFDESTE 

       130        140        150        160        170        180 
GGLALTREGG HHRRRIAHAG GDATGAEISR ALVEAVRARG LRTVENALVL DLLTDAEGRT 

       190        200        210        220        230        240 
AGVTLHVMGE GQHDGVGAVH APAVVLATGG MGQVFSATTN PSVSTGDGVA LALRAGAEVS 

       250        260        270        280        290        300 
DLEFVQFHPT VLFLGSDAEG QQPLVSEAVR GEGAHLVDAD GVRFMQGRHE LAELAPRDIV 

       310        320        330        340        350        360 
AKAITRRMQE HGADHMYLDA RHFGRTMWEH RFPTILAACR AHGIDPVTEP VPVAPAAHYA 

       370        380        390        400        410        420 
SGGVRTDAHG RTTVPGLYAC GEVACTGVHG ANRLASNSLL EGLVYAERIA ADIAAAHTAG 

       430        440        450        460        470        480 
TLHARVPAPL PHPDHSQHPR HPLLPPEARL TIQRIMTEGA GVLRSADSLA RAADRLHGLH 

       490        500        510        520        530        540 
AEAREALHEH GKTSEPGVDT WEATNLLCVA RVLVAAAARR EETRGCHWRE DHADRDDTTW 

       550        560        570        580 
RRHVVVRLNP DRTLAVHTTD TPEFPPTVHG AQPTHRPQEQ

« Hide

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Cross-references

Sequence databases

AL939116 Genomic DNA. Translation: CAB40882.1.
PIRT36393.
RefSeqNP_627590.1.

3D structure databases

HSSPHSSP built from PDB template 1CHU based on UniProtKB P10902.
ModBaseSearch...

Genome annotation databases

GeneID1098819.
GenomeReviewsGene locus SCO3382 in contig AL645882_GR.
KEGGsco:SCO3382.
NMPDRfig|100226.1.peg.3342.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9X8N8.
OMAGAYIWNR.

Enzyme and pathway databases

BioCycSCOE100226:SCO3382-MON.
BRENDA1.4.3.16. 1084.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004112. Fum_Rdtase/Succ_DH_flav_C.
IPR005288. NadB.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
TIGRFAMsTIGR00551. nadB. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameNADB_STRCO
AccessionPrimary (citable) accession number: Q9X8N8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 1, 1999
Last modified: November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents