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Protein

DNA repair protein radA

Gene

SCO3351

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repairUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiS16.A04.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein radAUniRule annotation
Gene namesi
Ordered Locus Names:SCO3351Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3351.

Structurei

3D structure databases

ProteinModelPortaliQ9X8L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 218150RECA_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RecA family. RadA subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiENOG4105DNJ. Bacteria.
COG1066. LUCA.
HOGENOMiHOG000218329.
InParanoidiQ9X8L5.
KOiK04485.
OMAiFEGERGH.
OrthoDBiEOG6DRPHC.
PhylomeDBiQ9X8L5.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR004504. DNA_repair_RadA.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PRINTSiPR01874. DNAREPAIRADA.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00416. sms. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X8L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARTKSAKE RPSYRCTECG WQTAKWLGRC PECQAWGTVE EYGAPAVRTT
60 70 80 90 100
TPGRVTTSAV PIGQVDGRQA TARSTGVPEL DRVLGGGLVP GAVVLVAGEP
110 120 130 140 150
GVGKSTLLLD VAAKSASDEH RTLYVTGEES ASQVRLRADR IHAIDDHLYL
160 170 180 190 200
AAETDLAAVL GHLDAVKPSL LILDSVQTVA SPEIDGAPGG MAQVREVAGA
210 220 230 240 250
LIRASKERGM STLLVGHVTK DGAIAGPRLL EHLVDVVLHF EGDRHARLRL
260 270 280 290 300
VRGVKNRYGT TDEVGCFELH DEGITGLADP SGLFLTRRAE PVPGTCLTVT
310 320 330 340 350
LEGRRPLVAE VQALTVDSQI PSPRRTTSGL ETSRVSMMLA VLEQRGRISA
360 370 380 390 400
LGKRDIYSAT VGGVKLSEPA ADLAVALALA SAASDTPLPK NLVAIGEVGL
410 420 430 440 450
AGEVRRVTGV QRRLSEAHRL GFTHALVPAD PGRVPDGMKV LEVADMGDAL
460
RVLPRSRRRE ATREEEDRR
Length:469
Mass (Da):49,839
Last modified:November 1, 1999 - v1
Checksum:i62A6102AC2A40BDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAB40851.1.
PIRiT36362.
RefSeqiNP_627559.1. NC_003888.3.
WP_011028928.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB40851; CAB40851; CAB40851.
GeneIDi1098788.
KEGGisco:SCO3351.
PATRICi23736458. VBIStrCoe124346_3414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAB40851.1.
PIRiT36362.
RefSeqiNP_627559.1. NC_003888.3.
WP_011028928.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9X8L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3351.

Protein family/group databases

MEROPSiS16.A04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB40851; CAB40851; CAB40851.
GeneIDi1098788.
KEGGisco:SCO3351.
PATRICi23736458. VBIStrCoe124346_3414.

Phylogenomic databases

eggNOGiENOG4105DNJ. Bacteria.
COG1066. LUCA.
HOGENOMiHOG000218329.
InParanoidiQ9X8L5.
KOiK04485.
OMAiFEGERGH.
OrthoDBiEOG6DRPHC.
PhylomeDBiQ9X8L5.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR004504. DNA_repair_RadA.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PRINTSiPR01874. DNAREPAIRADA.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00416. sms. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145Imported.

Entry informationi

Entry nameiQ9X8L5_STRCO
AccessioniPrimary (citable) accession number: Q9X8L5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.