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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Magnesium 2UniRule annotation1
Binding sitei16SubstrateUniRule annotation1
Binding sitei30SubstrateUniRule annotation1
Binding sitei42SubstrateUniRule annotation1
Metal bindingi52Magnesium 1UniRule annotation1
Metal bindingi57Magnesium 1UniRule annotation1
Metal bindingi57Magnesium 2UniRule annotation1
Metal bindingi84Magnesium 3UniRule annotation1
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi89Magnesium 1UniRule annotation1
Metal bindingi89Magnesium 3UniRule annotation1
Binding sitei126SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:SCO3409
ORF Names:SCE9.16
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375321 – 163Inorganic pyrophosphataseAdd BLAST163

Proteomic databases

PRIDEiQ9X8I9

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO3409

Structurei

3D structure databases

ProteinModelPortaliQ9X8I9
SMRiQ9X8I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F0N Bacteria
COG0221 LUCA
HOGENOMiHOG000236473
InParanoidiQ9X8I9
KOiK01507
OMAiDEPTFPG
OrthoDBiPOG091H05Q5
PhylomeDBiQ9X8I9

Family and domain databases

CDDicd00412 pyrophosphatase, 1 hit
Gene3Di3.90.80.10, 1 hit
HAMAPiMF_00209 Inorganic_PPase, 1 hit
InterProiView protein in InterPro
IPR008162 Pyrophosphatase
IPR036649 Pyrophosphatase_sf
PANTHERiPTHR10286 PTHR10286, 1 hit
PfamiView protein in Pfam
PF00719 Pyrophosphatase, 1 hit
SUPFAMiSSF50324 SSF50324, 1 hit
PROSITEiView protein in PROSITE
PS00387 PPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9X8I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFDVTIEIP KGSRNKYEVD HETGRIRLDR RLFTSTAYPT DYGFVENTLG
60 70 80 90 100
EDGDPLDALV ILDEPTFPGC LIRCRAIGMF RMTDEAGGDD KLLCVPSTDP
110 120 130 140 150
RVEHLRDIHH VSEFDRLEIQ HFFEVYKDLE PGKSVEGADW VGRTEAEAEI
160
ERSYKRFKDQ GGH
Length:163
Mass (Da):18,694
Last modified:November 1, 1999 - v1
Checksum:i2CEC6ED89FA59BFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA Translation: CAB42762.1
PIRiT36335
RefSeqiNP_627615.1, NC_003888.3
WP_003975424.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB42762; CAB42762; CAB42762
GeneIDi1098846
KEGGisco:SCO3409
PATRICifig|100226.15.peg.3472

Similar proteinsi

Entry informationi

Entry nameiIPYR_STRCO
AccessioniPrimary (citable) accession number: Q9X8I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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