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Q9X8I3

- GCH1_STRCO

UniProt

Q9X8I3 - GCH1_STRCO

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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901ZincBy similarity
Metal bindingi93 – 931ZincBy similarity
Metal bindingi163 – 1631ZincBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:SCO3403
ORF Names:SCE9.10c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201GTP cyclohydrolase 1PRO_0000119447Add
BLAST

Proteomic databases

PRIDEiQ9X8I3.

PTM databases

PhosSiteiP12011338.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi100226.SCO3403.

Structurei

3D structure databases

ProteinModelPortaliQ9X8I3.
SMRiQ9X8I3. Positions 15-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
InParanoidiQ9X8I3.
KOiK01495.
OMAiVYSHCEH.
OrthoDBiEOG6XHC8G.
PhylomeDBiQ9X8I3.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X8I3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDPVTLDGE GQIGEFDEKR AENAVRELLI AVGEDPDREG LRETPARVAR
60 70 80 90 100
AYREIFAGLW QEPEDVLTTT FDLGHDEMVL VKDIEVFSTC EHHLVPFRGV
110 120 130 140 150
AHVGYIPSTS GKITGLSKLA RLVDVYARRP QVQERLTTQI ADSLMEILEP
160 170 180 190 200
RGVIVVVECE HMCMSMRGIR KPGAKTLTSA VRGQLRDVAT RNEAMSLIMA

R
Length:201
Mass (Da):22,415
Last modified:November 1, 1999 - v1
Checksum:i4CC8FE6E76687B6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939116 Genomic DNA. Translation: CAB42756.1.
PIRiT36329.
RefSeqiNP_627609.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42756; CAB42756; CAB42756.
GeneIDi1098840.
KEGGisco:SCO3403.
PATRICi23736562. VBIStrCoe124346_3466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939116 Genomic DNA. Translation: CAB42756.1 .
PIRi T36329.
RefSeqi NP_627609.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9X8I3.
SMRi Q9X8I3. Positions 15-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO3403.

PTM databases

PhosSitei P12011338.

Proteomic databases

PRIDEi Q9X8I3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB42756 ; CAB42756 ; CAB42756 .
GeneIDi 1098840.
KEGGi sco:SCO3403.
PATRICi 23736562. VBIStrCoe124346_3466.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
InParanoidi Q9X8I3.
KOi K01495.
OMAi VYSHCEH.
OrthoDBi EOG6XHC8G.
PhylomeDBi Q9X8I3.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiGCH1_STRCO
AccessioniPrimary (citable) accession number: Q9X8I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3