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Q9X8I0

- FOLB_STRCO

UniProt

Q9X8I0 - FOLB_STRCO

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Protein

Dihydroneopterin aldolase

Gene
folB, SCO3400, SCE9.07
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin By similarity.

Catalytic activityi

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.

Pathwayi

GO - Molecular functioni

  1. dihydroneopterin aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Folate biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00077; UER00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolase (EC:4.1.2.25)
Short name:
DHNA
Gene namesi
Name:folB
Ordered Locus Names:SCO3400
ORF Names:SCE9.07
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Dihydroneopterin aldolasePRO_0000168287Add
BLAST

Proteomic databases

PRIDEiQ9X8I0.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3400.

Structurei

3D structure databases

ProteinModelPortaliQ9X8I0.

Family & Domainsi

Sequence similaritiesi

Belongs to the DHNA family.

Phylogenomic databases

eggNOGiCOG1539.
HOGENOMiHOG000217628.
KOiK01633.
OMAiVAIEMTR.
OrthoDBiEOG6G20SM.
PhylomeDBiQ9X8I0.

Family and domain databases

InterProiIPR006156. Dihydroneopterin_aldolase.
IPR006157. FolB_dom.
[Graphical view]
PfamiPF02152. FolB. 1 hit.
[Graphical view]
SMARTiSM00905. FolB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00525. folB. 1 hit.
TIGR00526. folB_dom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X8I0-1 [UniParc]FASTAAdd to Basket

« Hide

MDRVALRGLK ARGHHGVFPK EREDGQTFLV DIVLGLDTRP AAADDDLAKT    50
VHYGIVAEEV VAVVEGEPVN LVETLAERIA QVCLKHEGVE EVEVCVHKPD 100
APITVPFDDV TVTIIRSRV 119
Length:119
Mass (Da):13,002
Last modified:November 1, 1999 - v1
Checksum:i0E865735FA1A694D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939116 Genomic DNA. Translation: CAB42753.1.
PIRiT36326.
RefSeqiNP_627606.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42753; CAB42753; CAB42753.
GeneIDi1098837.
KEGGisco:SCO3400.
PATRICi23736556. VBIStrCoe124346_3463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939116 Genomic DNA. Translation: CAB42753.1 .
PIRi T36326.
RefSeqi NP_627606.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9X8I0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO3400.

Proteomic databases

PRIDEi Q9X8I0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB42753 ; CAB42753 ; CAB42753 .
GeneIDi 1098837.
KEGGi sco:SCO3400.
PATRICi 23736556. VBIStrCoe124346_3463.

Phylogenomic databases

eggNOGi COG1539.
HOGENOMi HOG000217628.
KOi K01633.
OMAi VAIEMTR.
OrthoDBi EOG6G20SM.
PhylomeDBi Q9X8I0.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00154 .

Family and domain databases

InterProi IPR006156. Dihydroneopterin_aldolase.
IPR006157. FolB_dom.
[Graphical view ]
Pfami PF02152. FolB. 1 hit.
[Graphical view ]
SMARTi SM00905. FolB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00525. folB. 1 hit.
TIGR00526. folB_dom. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiFOLB_STRCO
AccessioniPrimary (citable) accession number: Q9X8I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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