Q9X8I0 (FOLB_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydroneopterin aldolase
Short name=DHNA
EC=4.1.2.25

Gene names

Name:	folB
Ordered Locus Names:	SCO3400
ORF Names:	SCE9.07

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]

Taxonomic identifier

100226 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces coelicolor

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin By similarity.
Catalytic activity	2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.
Sequence similarities	Belongs to the DHNA family.

Ontologies

Keywords
Biological process	Folate biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	dihydroneopterin aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Dihydroneopterin aldolase		PRO_0000168287

Sequences

	Sequence		Length	Mass (Da)
	Q9X8I0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 0E865735FA1A694D	FASTA	119	13,002
	10 20 30 40 50 60 MDRVALRGLK ARGHHGVFPK EREDGQTFLV DIVLGLDTRP AAADDDLAKT VHYGIVAEEV 70 80 90 100 110 VAVVEGEPVN LVETLAERIA QVCLKHEGVE EVEVCVHKPD APITVPFDDV TVTIIRSRV

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939116 Genomic DNA. Translation: CAB42753.1.
PIR	T36326.
RefSeq	NP_627606.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9X8I0.
ModBase	Search...
Protein-protein interaction databases
STRING	100226.SCO3400.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB42753; CAB42753; CAB42753.
GeneID	1098837.
KEGG	sco:SCO3400.
PATRIC	23736556. VBIStrCoe124346_3463.
Phylogenomic databases
eggNOG	COG1539.
HOGENOM	HOG000217628.
KO	K01633.
OMA	LGQRFYI.
ProtClustDB	CLSK635777.
Enzyme and pathway databases
UniPathway	UPA00077; UER00154.
Family and domain databases
InterPro	IPR006156. Dihydroneopterin_aldolase. IPR006157. FolB_dom. [Graphical view]
Pfam	PF02152. FolB. 1 hit. [Graphical view]
SMART	SM00905. FolB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00525. folB. 1 hit. TIGR00526. folB_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FOLB_STRCO

Accession

Primary (citable) accession number: Q9X8I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program