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Protein

Dihydroneopterin aldolase

Gene

folB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.By similarity

Catalytic activityi

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.

Pathwayi

GO - Molecular functioni

  1. dihydroneopterin aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Folate biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00077; UER00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolase (EC:4.1.2.25)
Short name:
DHNA
Gene namesi
Name:folB
Ordered Locus Names:SCO3400
ORF Names:SCE9.07
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Dihydroneopterin aldolasePRO_0000168287Add
BLAST

Proteomic databases

PRIDEiQ9X8I0.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3400.

Structurei

3D structure databases

ProteinModelPortaliQ9X8I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHNA family.Curated

Phylogenomic databases

eggNOGiCOG1539.
HOGENOMiHOG000217628.
InParanoidiQ9X8I0.
KOiK01633.
OMAiGHYKSVA.
OrthoDBiEOG6G20SM.
PhylomeDBiQ9X8I0.

Family and domain databases

InterProiIPR006156. Dihydroneopterin_aldolase.
IPR006157. FolB_dom.
[Graphical view]
PfamiPF02152. FolB. 1 hit.
[Graphical view]
SMARTiSM00905. FolB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00525. folB. 1 hit.
TIGR00526. folB_dom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X8I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRVALRGLK ARGHHGVFPK EREDGQTFLV DIVLGLDTRP AAADDDLAKT
60 70 80 90 100
VHYGIVAEEV VAVVEGEPVN LVETLAERIA QVCLKHEGVE EVEVCVHKPD
110
APITVPFDDV TVTIIRSRV
Length:119
Mass (Da):13,002
Last modified:November 1, 1999 - v1
Checksum:i0E865735FA1A694D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAB42753.1.
PIRiT36326.
RefSeqiNP_627606.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42753; CAB42753; CAB42753.
GeneIDi1098837.
KEGGisco:SCO3400.
PATRICi23736556. VBIStrCoe124346_3463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAB42753.1.
PIRiT36326.
RefSeqiNP_627606.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9X8I0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3400.

Proteomic databases

PRIDEiQ9X8I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB42753; CAB42753; CAB42753.
GeneIDi1098837.
KEGGisco:SCO3400.
PATRICi23736556. VBIStrCoe124346_3463.

Phylogenomic databases

eggNOGiCOG1539.
HOGENOMiHOG000217628.
InParanoidiQ9X8I0.
KOiK01633.
OMAiGHYKSVA.
OrthoDBiEOG6G20SM.
PhylomeDBiQ9X8I0.

Enzyme and pathway databases

UniPathwayiUPA00077; UER00154.

Family and domain databases

InterProiIPR006156. Dihydroneopterin_aldolase.
IPR006157. FolB_dom.
[Graphical view]
PfamiPF02152. FolB. 1 hit.
[Graphical view]
SMARTiSM00905. FolB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00525. folB. 1 hit.
TIGR00526. folB_dom. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiFOLB_STRCO
AccessioniPrimary (citable) accession number: Q9X8I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.