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Q9X8I0

- FOLB_STRCO

UniProt

Q9X8I0 - FOLB_STRCO

Protein

Dihydroneopterin aldolase

Gene

folB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.By similarity

    Catalytic activityi

    2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.

    Pathwayi

    GO - Molecular functioni

    1. dihydroneopterin aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Folate biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00077; UER00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroneopterin aldolase (EC:4.1.2.25)
    Short name:
    DHNA
    Gene namesi
    Name:folB
    Ordered Locus Names:SCO3400
    ORF Names:SCE9.07
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119Dihydroneopterin aldolasePRO_0000168287Add
    BLAST

    Proteomic databases

    PRIDEiQ9X8I0.

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO3400.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9X8I0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHNA family.Curated

    Phylogenomic databases

    eggNOGiCOG1539.
    HOGENOMiHOG000217628.
    KOiK01633.
    OMAiVAIEMTR.
    OrthoDBiEOG6G20SM.
    PhylomeDBiQ9X8I0.

    Family and domain databases

    InterProiIPR006156. Dihydroneopterin_aldolase.
    IPR006157. FolB_dom.
    [Graphical view]
    PfamiPF02152. FolB. 1 hit.
    [Graphical view]
    SMARTiSM00905. FolB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00525. folB. 1 hit.
    TIGR00526. folB_dom. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9X8I0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRVALRGLK ARGHHGVFPK EREDGQTFLV DIVLGLDTRP AAADDDLAKT    50
    VHYGIVAEEV VAVVEGEPVN LVETLAERIA QVCLKHEGVE EVEVCVHKPD 100
    APITVPFDDV TVTIIRSRV 119
    Length:119
    Mass (Da):13,002
    Last modified:November 1, 1999 - v1
    Checksum:i0E865735FA1A694D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939116 Genomic DNA. Translation: CAB42753.1.
    PIRiT36326.
    RefSeqiNP_627606.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB42753; CAB42753; CAB42753.
    GeneIDi1098837.
    KEGGisco:SCO3400.
    PATRICi23736556. VBIStrCoe124346_3463.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939116 Genomic DNA. Translation: CAB42753.1 .
    PIRi T36326.
    RefSeqi NP_627606.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9X8I0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO3400.

    Proteomic databases

    PRIDEi Q9X8I0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB42753 ; CAB42753 ; CAB42753 .
    GeneIDi 1098837.
    KEGGi sco:SCO3400.
    PATRICi 23736556. VBIStrCoe124346_3463.

    Phylogenomic databases

    eggNOGi COG1539.
    HOGENOMi HOG000217628.
    KOi K01633.
    OMAi VAIEMTR.
    OrthoDBi EOG6G20SM.
    PhylomeDBi Q9X8I0.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00154 .

    Family and domain databases

    InterProi IPR006156. Dihydroneopterin_aldolase.
    IPR006157. FolB_dom.
    [Graphical view ]
    Pfami PF02152. FolB. 1 hit.
    [Graphical view ]
    SMARTi SM00905. FolB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00525. folB. 1 hit.
    TIGR00526. folB_dom. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiFOLB_STRCO
    AccessioniPrimary (citable) accession number: Q9X8I0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3