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Protein

Dihydroneopterin aldolase

Gene

folB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.By similarity

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.By similarity

Pathway: tetrahydrofolate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Dihydroneopterin aldolase (folB)
  4. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211SubstrateBy similarity
Binding sitei53 – 531SubstrateBy similarity
Active sitei98 – 981Proton donor/acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Folate biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00077; UER00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolase (EC:4.1.2.25)
Short name:
DHNA
Alternative name(s):
7,8-dihydroneopterin aldolase
Gene namesi
Name:folB
Ordered Locus Names:SCO3400
ORF Names:SCE9.07
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Dihydroneopterin aldolasePRO_0000168287Add
BLAST

Proteomic databases

PRIDEiQ9X8I0.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3400.

Structurei

3D structure databases

ProteinModelPortaliQ9X8I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 732Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHNA family.Curated

Phylogenomic databases

eggNOGiCOG1539.
HOGENOMiHOG000217628.
InParanoidiQ9X8I0.
KOiK01633.
OMAiGHYKSVA.
OrthoDBiEOG6G20SM.
PhylomeDBiQ9X8I0.

Family and domain databases

InterProiIPR006156. Dihydroneopterin_aldolase.
IPR006157. FolB_dom.
[Graphical view]
PfamiPF02152. FolB. 1 hit.
[Graphical view]
SMARTiSM00905. FolB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00525. folB. 1 hit.
TIGR00526. folB_dom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X8I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRVALRGLK ARGHHGVFPK EREDGQTFLV DIVLGLDTRP AAADDDLAKT
60 70 80 90 100
VHYGIVAEEV VAVVEGEPVN LVETLAERIA QVCLKHEGVE EVEVCVHKPD
110
APITVPFDDV TVTIIRSRV
Length:119
Mass (Da):13,002
Last modified:November 1, 1999 - v1
Checksum:i0E865735FA1A694D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAB42753.1.
PIRiT36326.
RefSeqiNP_627606.1. NC_003888.3.
WP_011028954.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42753; CAB42753; CAB42753.
GeneIDi1098837.
KEGGisco:SCO3400.
PATRICi23736556. VBIStrCoe124346_3463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAB42753.1.
PIRiT36326.
RefSeqiNP_627606.1. NC_003888.3.
WP_011028954.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9X8I0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3400.

Proteomic databases

PRIDEiQ9X8I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB42753; CAB42753; CAB42753.
GeneIDi1098837.
KEGGisco:SCO3400.
PATRICi23736556. VBIStrCoe124346_3463.

Phylogenomic databases

eggNOGiCOG1539.
HOGENOMiHOG000217628.
InParanoidiQ9X8I0.
KOiK01633.
OMAiGHYKSVA.
OrthoDBiEOG6G20SM.
PhylomeDBiQ9X8I0.

Enzyme and pathway databases

UniPathwayiUPA00077; UER00154.

Family and domain databases

InterProiIPR006156. Dihydroneopterin_aldolase.
IPR006157. FolB_dom.
[Graphical view]
PfamiPF02152. FolB. 1 hit.
[Graphical view]
SMARTiSM00905. FolB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00525. folB. 1 hit.
TIGR00526. folB_dom. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiFOLB_STRCO
AccessioniPrimary (citable) accession number: Q9X8I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.