Q9X8G1 (Q9X8G1_STRCO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase RuleBase RU003903
EC=1.5.1.2 RuleBase RU003903

Gene names

Ordered Locus Names:

SCO3337

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H. RuleBase RU003903
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. RuleBase RU003903
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family. RuleBase RU003903

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis RuleBase RU003903
Ligand	NADP RuleBase RU003903
Molecular function	Oxidoreductase RuleBase RU003903
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9X8G1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 291D9889EB4AB115	FASTA	284	29,806
	10 20 30 40 50 60 MTPDHAHTPE GTEPMTQKVA VLGTGKIGEA LLSGMIGAGW APADLLVTAR RRERADELRA 70 80 90 100 110 120 RHGVTPVTNA EAAKAADTLI LTVKPQDMGT LLDELAPHVP ADRLVISGAA GVPTSFFEER 130 140 150 160 170 180 LAPGTPVVRV MTNTPALVDE AMSVISAGTH ATAAHLTHTE EIFGAVGKTL RVPESQQDAC 190 200 210 220 230 240 TALSGSGPAY FFYLVEAMTD AGILLGLPRD KAHDLIVQSA IGAAKMLRDS GEHPVKLREN 250 260 270 280 VTSPAGTTIN AIRELENHGV RAALIAALEA ARDRSRELAT GTKD

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939116 Genomic DNA. Translation: CAB42663.1.
PIR	T36286.
RefSeq	NP_627546.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9X8G1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1098774.
GenomeReviews	Gene locus SCO3337 in contig AL645882_GR.
KEGG	sco:SCO3337.
NMPDR	fig|100226.1.peg.3297.
PATRIC	23736424. VBIStrCoe124346_3397.
Phylogenomic databases
HOGENOM	HBG726602.
OMA	RTFNEHQ.
PhylomeDB	Q9X8G1.
ProtClustDB	CLSK902525.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9X8G1_STRCO

Accession

Primary (citable) accession number: Q9X8G1

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)