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Q9X844

- PANC_STRCO

UniProt

Q9X844 - PANC_STRCO

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Protein
Pantothenate synthetase
Gene
panC, SCO3383, SCE126.01c, SCE94.34c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton donor By similarity
Binding sitei65 – 651Beta-alanine By similarity
Binding sitei65 – 651Pantoate By similarity
Binding sitei158 – 1581Pantoate By similarity
Binding sitei181 – 1811ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388ATP By similarity
Nucleotide bindingi152 – 1554ATP By similarity
Nucleotide bindingi189 – 1924ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:SCO3383
ORF Names:SCE126.01c, SCE94.34c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Pantothenate synthetaseUniRule annotation
PRO_0000128278Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO3383.

Structurei

3D structure databases

ProteinModelPortaliQ9X844.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiGGEPQVR.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ9X844.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X844-1 [UniParc]FASTAAdd to Basket

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MTTPTPPVLL RTAGELHARV RRGRRAVVMT MGALHEGHAT LIRTARDIAG    50
PDGEVVVTVF VNPLQFGAGE DLDRYPRTLD ADLEIAGRAG ADAVFAPAVD 100
EVYPGGEPQV RVTAGPMGGR LEGASRPGHF DGMLTVVAKL LHLTRPDLAL 150
YGQKDAQQLA LIRRMVRDLN FGVEIVGVPT VREEDGLALS SRNRYLSTAE 200
RRTALALSQA LFAGLDRHAA QEALCARARE VPATQARAEA LSALGESRAA 250
ADAHAVATSA PGSATAVRDA ARLVLDDAAR ATPPLELDYL ALVDPSDFTE 300
IGDDHTGEAV LAVAARVGAT RLIDNVHLTF GPLGAAS 337
Length:337
Mass (Da):35,456
Last modified:May 30, 2000 - v2
Checksum:i3C948F7014A2913C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939116 Genomic DNA. Translation: CAD55315.1.
RefSeqiNP_733602.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAD55315; CAD55315; CAD55315.
GeneIDi1098820.
KEGGisco:SCO3383.
PATRICi23736522. VBIStrCoe124346_3446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939116 Genomic DNA. Translation: CAD55315.1 .
RefSeqi NP_733602.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9X844.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO3383.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD55315 ; CAD55315 ; CAD55315 .
GeneIDi 1098820.
KEGGi sco:SCO3383.
PATRICi 23736522. VBIStrCoe124346_3446.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi GGEPQVR.
OrthoDBi EOG6Z6FZ4.
PhylomeDBi Q9X844.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPANC_STRCO
AccessioniPrimary (citable) accession number: Q9X844
Secondary accession number(s): Q9X8N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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