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Q9X844

- PANC_STRCO

UniProt

Q9X844 - PANC_STRCO

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Protein

Pantothenate synthetase

Gene

panC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton donorUniRule annotation
Binding sitei65 – 651Beta-alanineUniRule annotation
Binding sitei65 – 651PantoateUniRule annotation
Binding sitei158 – 1581PantoateUniRule annotation
Binding sitei181 – 1811ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388ATPUniRule annotation
Nucleotide bindingi152 – 1554ATPUniRule annotation
Nucleotide bindingi189 – 1924ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:SCO3383
ORF Names:SCE126.01c, SCE94.34c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Pantothenate synthetasePRO_0000128278Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO3383.

Structurei

3D structure databases

ProteinModelPortaliQ9X844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
InParanoidiQ9X844.
KOiK01918.
OMAiGGEPQVR.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ9X844.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9X844-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTPTPPVLL RTAGELHARV RRGRRAVVMT MGALHEGHAT LIRTARDIAG
60 70 80 90 100
PDGEVVVTVF VNPLQFGAGE DLDRYPRTLD ADLEIAGRAG ADAVFAPAVD
110 120 130 140 150
EVYPGGEPQV RVTAGPMGGR LEGASRPGHF DGMLTVVAKL LHLTRPDLAL
160 170 180 190 200
YGQKDAQQLA LIRRMVRDLN FGVEIVGVPT VREEDGLALS SRNRYLSTAE
210 220 230 240 250
RRTALALSQA LFAGLDRHAA QEALCARARE VPATQARAEA LSALGESRAA
260 270 280 290 300
ADAHAVATSA PGSATAVRDA ARLVLDDAAR ATPPLELDYL ALVDPSDFTE
310 320 330
IGDDHTGEAV LAVAARVGAT RLIDNVHLTF GPLGAAS
Length:337
Mass (Da):35,456
Last modified:May 30, 2000 - v2
Checksum:i3C948F7014A2913C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAD55315.1.
RefSeqiNP_733602.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAD55315; CAD55315; CAD55315.
GeneIDi1098820.
KEGGisco:SCO3383.
PATRICi23736522. VBIStrCoe124346_3446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAD55315.1 .
RefSeqi NP_733602.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9X844.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO3383.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD55315 ; CAD55315 ; CAD55315 .
GeneIDi 1098820.
KEGGi sco:SCO3383.
PATRICi 23736522. VBIStrCoe124346_3446.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
InParanoidi Q9X844.
KOi K01918.
OMAi GGEPQVR.
OrthoDBi EOG6Z6FZ4.
PhylomeDBi Q9X844.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPANC_STRCO
AccessioniPrimary (citable) accession number: Q9X844
Secondary accession number(s): Q9X8N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3