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Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi227Copper ASequence analysis1
Metal bindingi262Copper ASequence analysis1
Metal bindingi266Copper ASequence analysis1
Metal bindingi270Copper ASequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Mtb92
Gene namesi
Name:ctaC
Ordered Locus Names:SCO2156
ORF Names:SC6G10.29c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000000606334 – 319Probable cytochrome c oxidase subunit 2Add BLAST286

Proteomic databases

PRIDEiQ9X814

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO2156

Structurei

3D structure databases

ProteinModelPortaliQ9X814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA
HOGENOMiHOG000245527
InParanoidiQ9X814
KOiK02275
OMAiHAFMPIA
OrthoDBiPOG091H05L4
PhylomeDBiQ9X814

Family and domain databases

Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 2 hits
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9X814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPNGSDRSP RRPMRRKLLQ ALTAGLVLAT ATGCTYEDFP RLGMPTPTTE
60 70 80 90 100
EAPRILSLWQ GSWAAALATG VLVWGLILWS VFFHRRSRTK VEVPPQTRYN
110 120 130 140 150
LPIEALYTMV PLVIVSVLFY FTARDESDLM SLNKKPDLTV NVVGFQWSWC
160 170 180 190 200
FNHIEDVPGS TGDAKTSKEL AGIPDRFIED FPANAGGVYD CGTPGTENPQ
210 220 230 240 250
TGNPGPTLWL PKGKTVRFVL TSRDVIHSFW VVPFLMKQDV IPGHTNAFEV
260 270 280 290 300
TPNKEGTFLG KCAELCGVDH SRMLFNVKVV SPERYEQHLQ DLAKKGQTGY
310
VPAGIAQTSH EKNRETNNL
Length:319
Mass (Da):35,447
Last modified:November 1, 1999 - v1
Checksum:iEC266914F4DFA79C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939111 Genomic DNA Translation: CAB39883.1
PIRiT35538
RefSeqiNP_626412.1, NC_003888.3
WP_011028168.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB39883; CAB39883; CAB39883
GeneIDi1097590
KEGGisco:SCO2156
PATRICifig|100226.15.peg.2191

Similar proteinsi

Entry informationi

Entry nameiCOX2_STRCO
AccessioniPrimary (citable) accession number: Q9X814
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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