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Q9X814 (COX2_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Mtb92
Gene names
Name:ctaC
Ordered Locus Names:SCO2156
ORF Names:SC6G10.29c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 319286Probable cytochrome c oxidase subunit 2
PRO_0000006063

Regions

Transmembrane63 – 8321Helical; Potential
Transmembrane101 – 12121Helical; Potential

Sites

Metal binding2271Copper A Potential
Metal binding2621Copper A Potential
Metal binding2661Copper A Potential
Metal binding2701Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
Q9X814 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: EC266914F4DFA79C

FASTA31935,447
        10         20         30         40         50         60 
MSPNGSDRSP RRPMRRKLLQ ALTAGLVLAT ATGCTYEDFP RLGMPTPTTE EAPRILSLWQ 

        70         80         90        100        110        120 
GSWAAALATG VLVWGLILWS VFFHRRSRTK VEVPPQTRYN LPIEALYTMV PLVIVSVLFY 

       130        140        150        160        170        180 
FTARDESDLM SLNKKPDLTV NVVGFQWSWC FNHIEDVPGS TGDAKTSKEL AGIPDRFIED 

       190        200        210        220        230        240 
FPANAGGVYD CGTPGTENPQ TGNPGPTLWL PKGKTVRFVL TSRDVIHSFW VVPFLMKQDV 

       250        260        270        280        290        300 
IPGHTNAFEV TPNKEGTFLG KCAELCGVDH SRMLFNVKVV SPERYEQHLQ DLAKKGQTGY 

       310 
VPAGIAQTSH EKNRETNNL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939111 Genomic DNA. Translation: CAB39883.1.
PIRT35538.
RefSeqNP_626412.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9X814.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO2156.

Proteomic databases

PRIDEQ9X814.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB39883; CAB39883; CAB39883.
GeneID1097590.
KEGGsco:SCO2156.
PATRIC23733964. VBIStrCoe124346_2191.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000245527.
KOK02275.
OMAMRELWTW.
OrthoDBEOG68SVXT.
PhylomeDBQ9X814.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_STRCO
AccessionPrimary (citable) accession number: Q9X814
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families