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Q9X814

- COX2_STRCO

UniProt

Q9X814 - COX2_STRCO

Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.By similarity
    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi227 – 2271Copper ASequence Analysis
    Metal bindingi262 – 2621Copper ASequence Analysis
    Metal bindingi266 – 2661Copper ASequence Analysis
    Metal bindingi270 – 2701Copper ASequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Mtb92
    Gene namesi
    Name:ctaC
    Ordered Locus Names:SCO2156
    ORF Names:SC6G10.29c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 319286Probable cytochrome c oxidase subunit 2PRO_0000006063Add
    BLAST

    Proteomic databases

    PRIDEiQ9X814.

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO2156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9X814.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000245527.
    KOiK02275.
    OMAiMRELWTW.
    OrthoDBiEOG68SVXT.
    PhylomeDBiQ9X814.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 2 hits.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9X814-1 [UniParc]FASTAAdd to Basket

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    MSPNGSDRSP RRPMRRKLLQ ALTAGLVLAT ATGCTYEDFP RLGMPTPTTE    50
    EAPRILSLWQ GSWAAALATG VLVWGLILWS VFFHRRSRTK VEVPPQTRYN 100
    LPIEALYTMV PLVIVSVLFY FTARDESDLM SLNKKPDLTV NVVGFQWSWC 150
    FNHIEDVPGS TGDAKTSKEL AGIPDRFIED FPANAGGVYD CGTPGTENPQ 200
    TGNPGPTLWL PKGKTVRFVL TSRDVIHSFW VVPFLMKQDV IPGHTNAFEV 250
    TPNKEGTFLG KCAELCGVDH SRMLFNVKVV SPERYEQHLQ DLAKKGQTGY 300
    VPAGIAQTSH EKNRETNNL 319
    Length:319
    Mass (Da):35,447
    Last modified:November 1, 1999 - v1
    Checksum:iEC266914F4DFA79C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939111 Genomic DNA. Translation: CAB39883.1.
    PIRiT35538.
    RefSeqiNP_626412.1. NC_003888.3.
    WP_011028168.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB39883; CAB39883; CAB39883.
    GeneIDi1097590.
    KEGGisco:SCO2156.
    PATRICi23733964. VBIStrCoe124346_2191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939111 Genomic DNA. Translation: CAB39883.1 .
    PIRi T35538.
    RefSeqi NP_626412.1. NC_003888.3.
    WP_011028168.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9X814.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO2156.

    Proteomic databases

    PRIDEi Q9X814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB39883 ; CAB39883 ; CAB39883 .
    GeneIDi 1097590.
    KEGGi sco:SCO2156.
    PATRICi 23733964. VBIStrCoe124346_2191.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000245527.
    KOi K02275.
    OMAi MRELWTW.
    OrthoDBi EOG68SVXT.
    PhylomeDBi Q9X814.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 2 hits.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiCOX2_STRCO
    AccessioniPrimary (citable) accession number: Q9X814
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3