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Protein

Probable cytochrome c oxidase subunit 1-alpha

Gene

ctaD1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+By similarityNote: Binds 1 copper B ion per subunit.By similarity
  • hemeBy similarityNote: Binds 2 heme groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90Iron (heme A axial ligand)By similarity1
Metal bindingi268Copper BBy similarity1
Metal bindingi272Copper BBy similarity1
Metal bindingi317Copper BBy similarity1
Metal bindingi318Copper BBy similarity1
Metal bindingi401Iron (heme A3 axial ligand)By similarity1
Metal bindingi403Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-alpha
Cytochrome c oxidase polypeptide I-alpha
Gene namesi
Name:ctaD1
Ordered Locus Names:SCO2155
ORF Names:SC6G10.28c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834521 – 578Probable cytochrome c oxidase subunit 1-alphaAdd BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi100226.SCO2155

Structurei

3D structure databases

ProteinModelPortaliQ9X813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9 Bacteria
COG0843 LUCA
HOGENOMiHOG000085274
InParanoidiQ9X813
KOiK02274
OMAiMSFWLLP
OrthoDBiPOG091H042R
PhylomeDBiQ9X813

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR014241 Cyt_c_oxidase_su1_bac
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9X813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILNEPQGA SAAEDSYENE LPVRRKQPGN VVIKWLTTTD HKTIGTMYLV
60 70 80 90 100
TSFAFFVIGG VMALFMRAEL ARPGLQIMSN EQFNQAFTMH GTIMLLMFAT
110 120 130 140 150
PLFAGFANWI MPLQIGAPDV AFPRLNMFAY WLYLFGSTIA VGGFLTPQGA
160 170 180 190 200
ADFGWFAYSP LSDAVHSPGI GGDLWIMGLA FSGFGTILGS VNFITTIICM
210 220 230 240 250
RAPGMTMFRM PIFTWNVLLT GVLVLLAFPV LAAALFALEA DRKFGAHIFD
260 270 280 290 300
SSNGGALLWQ HLFWFFGHPE VYIIALPFFG IVSEIIPVFS RKPIFGYMGL
310 320 330 340 350
IGATIAIAGL SVTVWAHHMY VTGGVLLPFF SFMTFLIAVP TGVKFFNWIG
360 370 380 390 400
TMWKGSLSFE TPMLWSTGFL ITFLFGGLTG VILASPPLDF HVSDSYFVVA
410 420 430 440 450
HFHYVVFGTV VFAMFAGFHF WWPKFTGKML DERLGKITFW TLFVGFHGTF
460 470 480 490 500
LVQHWLGAEG MPRRYADYLA ADGFTALNTI STISSFLLGM SILPFFYNIW
510 520 530 540 550
KTAKYGKKIE VDDPWGYGRS LEWATSCPPP RHNFLTLPRI RSESPAFDLH
560 570
HPEISAIDQL ENVGHGEKAL AGGKEAGK
Length:578
Mass (Da):64,122
Last modified:November 1, 1999 - v1
Checksum:i2A25FF2A913DC461
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939111 Genomic DNA Translation: CAB39882.1
PIRiT35537
RefSeqiNP_626411.1, NC_003888.3
WP_003976660.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB39882; CAB39882; CAB39882
GeneIDi1097589
KEGGisco:SCO2155
PATRICifig|100226.15.peg.2190

Similar proteinsi

Entry informationi

Entry nameiCOX1A_STRCO
AccessioniPrimary (citable) accession number: Q9X813
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health