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Q9X813

- COX1A_STRCO

UniProt

Q9X813 - COX1A_STRCO

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Protein

Probable cytochrome c oxidase subunit 1-alpha

Gene
ctaD1, SCO2155, SC6G10.28c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit By similarity.
Binds 2 heme groups per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901Iron (heme A axial ligand) By similarity
Metal bindingi268 – 2681Copper B By similarity
Metal bindingi272 – 2721Copper B By similarity
Metal bindingi317 – 3171Copper B By similarity
Metal bindingi318 – 3181Copper B By similarity
Metal bindingi401 – 4011Iron (heme A3 axial ligand) By similarity
Metal bindingi403 – 4031Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-alpha
Cytochrome c oxidase polypeptide I-alpha
Gene namesi
Name:ctaD1
Ordered Locus Names:SCO2155
ORF Names:SC6G10.28c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421Helical; Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Transmembranei125 – 14521Helical; Reviewed predictionAdd
BLAST
Transmembranei174 – 19421Helical; Reviewed predictionAdd
BLAST
Transmembranei217 – 23721Helical; Reviewed predictionAdd
BLAST
Transmembranei262 – 28221Helical; Reviewed predictionAdd
BLAST
Transmembranei294 – 31421Helical; Reviewed predictionAdd
BLAST
Transmembranei319 – 33921Helical; Reviewed predictionAdd
BLAST
Transmembranei363 – 38321Helical; Reviewed predictionAdd
BLAST
Transmembranei402 – 42221Helical; Reviewed predictionAdd
BLAST
Transmembranei437 – 45721Helical; Reviewed predictionAdd
BLAST
Transmembranei480 – 50021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Probable cytochrome c oxidase subunit 1-alphaPRO_0000183452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Protein-protein interaction databases

STRINGi100226.SCO2155.

Structurei

3D structure databases

ProteinModelPortaliQ9X813.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02274.
OMAiMGMTRRV.
OrthoDBiEOG6B35XR.
PhylomeDBiQ9X813.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9X813-1 [UniParc]FASTAAdd to Basket

« Hide

MSILNEPQGA SAAEDSYENE LPVRRKQPGN VVIKWLTTTD HKTIGTMYLV    50
TSFAFFVIGG VMALFMRAEL ARPGLQIMSN EQFNQAFTMH GTIMLLMFAT 100
PLFAGFANWI MPLQIGAPDV AFPRLNMFAY WLYLFGSTIA VGGFLTPQGA 150
ADFGWFAYSP LSDAVHSPGI GGDLWIMGLA FSGFGTILGS VNFITTIICM 200
RAPGMTMFRM PIFTWNVLLT GVLVLLAFPV LAAALFALEA DRKFGAHIFD 250
SSNGGALLWQ HLFWFFGHPE VYIIALPFFG IVSEIIPVFS RKPIFGYMGL 300
IGATIAIAGL SVTVWAHHMY VTGGVLLPFF SFMTFLIAVP TGVKFFNWIG 350
TMWKGSLSFE TPMLWSTGFL ITFLFGGLTG VILASPPLDF HVSDSYFVVA 400
HFHYVVFGTV VFAMFAGFHF WWPKFTGKML DERLGKITFW TLFVGFHGTF 450
LVQHWLGAEG MPRRYADYLA ADGFTALNTI STISSFLLGM SILPFFYNIW 500
KTAKYGKKIE VDDPWGYGRS LEWATSCPPP RHNFLTLPRI RSESPAFDLH 550
HPEISAIDQL ENVGHGEKAL AGGKEAGK 578
Length:578
Mass (Da):64,122
Last modified:November 1, 1999 - v1
Checksum:i2A25FF2A913DC461
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939111 Genomic DNA. Translation: CAB39882.1.
PIRiT35537.
RefSeqiNP_626411.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB39882; CAB39882; CAB39882.
GeneIDi1097589.
KEGGisco:SCO2155.
PATRICi23733962. VBIStrCoe124346_2190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939111 Genomic DNA. Translation: CAB39882.1 .
PIRi T35537.
RefSeqi NP_626411.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9X813.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO2155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB39882 ; CAB39882 ; CAB39882 .
GeneIDi 1097589.
KEGGi sco:SCO2155.
PATRICi 23733962. VBIStrCoe124346_2190.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02274.
OMAi MGMTRRV.
OrthoDBi EOG6B35XR.
PhylomeDBi Q9X813.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiCOX1A_STRCO
AccessioniPrimary (citable) accession number: Q9X813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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