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Q9X813

- COX1A_STRCO

UniProt

Q9X813 - COX1A_STRCO

Protein

Probable cytochrome c oxidase subunit 1-alpha

Gene

ctaD1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B per subunit.By similarity
    Binds 2 heme groups per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi90 – 901Iron (heme A axial ligand)By similarity
    Metal bindingi268 – 2681Copper BBy similarity
    Metal bindingi272 – 2721Copper BBy similarity
    Metal bindingi317 – 3171Copper BBy similarity
    Metal bindingi318 – 3181Copper BBy similarity
    Metal bindingi401 – 4011Iron (heme A3 axial ligand)By similarity
    Metal bindingi403 – 4031Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1-alpha
    Cytochrome c oxidase polypeptide I-alpha
    Gene namesi
    Name:ctaD1
    Ordered Locus Names:SCO2155
    ORF Names:SC6G10.28c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 578578Probable cytochrome c oxidase subunit 1-alphaPRO_0000183452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Subunit structurei

    Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

    Protein-protein interaction databases

    STRINGi100226.SCO2155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9X813.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 33921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei480 – 50021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK02274.
    OMAiMGMTRRV.
    OrthoDBiEOG6B35XR.
    PhylomeDBiQ9X813.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9X813-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSILNEPQGA SAAEDSYENE LPVRRKQPGN VVIKWLTTTD HKTIGTMYLV    50
    TSFAFFVIGG VMALFMRAEL ARPGLQIMSN EQFNQAFTMH GTIMLLMFAT 100
    PLFAGFANWI MPLQIGAPDV AFPRLNMFAY WLYLFGSTIA VGGFLTPQGA 150
    ADFGWFAYSP LSDAVHSPGI GGDLWIMGLA FSGFGTILGS VNFITTIICM 200
    RAPGMTMFRM PIFTWNVLLT GVLVLLAFPV LAAALFALEA DRKFGAHIFD 250
    SSNGGALLWQ HLFWFFGHPE VYIIALPFFG IVSEIIPVFS RKPIFGYMGL 300
    IGATIAIAGL SVTVWAHHMY VTGGVLLPFF SFMTFLIAVP TGVKFFNWIG 350
    TMWKGSLSFE TPMLWSTGFL ITFLFGGLTG VILASPPLDF HVSDSYFVVA 400
    HFHYVVFGTV VFAMFAGFHF WWPKFTGKML DERLGKITFW TLFVGFHGTF 450
    LVQHWLGAEG MPRRYADYLA ADGFTALNTI STISSFLLGM SILPFFYNIW 500
    KTAKYGKKIE VDDPWGYGRS LEWATSCPPP RHNFLTLPRI RSESPAFDLH 550
    HPEISAIDQL ENVGHGEKAL AGGKEAGK 578
    Length:578
    Mass (Da):64,122
    Last modified:November 1, 1999 - v1
    Checksum:i2A25FF2A913DC461
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939111 Genomic DNA. Translation: CAB39882.1.
    PIRiT35537.
    RefSeqiNP_626411.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB39882; CAB39882; CAB39882.
    GeneIDi1097589.
    KEGGisco:SCO2155.
    PATRICi23733962. VBIStrCoe124346_2190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939111 Genomic DNA. Translation: CAB39882.1 .
    PIRi T35537.
    RefSeqi NP_626411.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9X813.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO2155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB39882 ; CAB39882 ; CAB39882 .
    GeneIDi 1097589.
    KEGGi sco:SCO2155.
    PATRICi 23733962. VBIStrCoe124346_2190.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K02274.
    OMAi MGMTRRV.
    OrthoDBi EOG6B35XR.
    PhylomeDBi Q9X813.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiCOX1A_STRCO
    AccessioniPrimary (citable) accession number: Q9X813
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3