Q9X812 (COX4_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytochrome c oxidase polypeptide 4
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 4
Cytochrome c oxidase polypeptide IV

Gene names

Name:	ctaF
Ordered Locus Names:	SCO2154
ORF Names:	SC6G10.27c

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]

Taxonomic identifier

100226 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces coelicolor

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of cytochrome c oxidase, its function is unknown By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subunit structure	Associates with subunits I, II and III to form cytochrome c oxidase By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase bacterial subunit CtaF family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	Probable cytochrome c oxidase polypeptide 4		PRO_0000220022
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	110 – 127	18	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9X812 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 12A6AFCFC3376438	FASTA	132	14,581
	10 20 30 40 50 60 MKIQGKMFIW LSVFILAVAV VYGYWSKEPA GTTALFLAFG LAIMIGFYLA FTARRVDAGA 70 80 90 100 110 120 QDDMEADVAD EAGEVGFFSP HSWQPLSLAV GGALAFLGIA VGWWVMYFSA PILMVGLFGW 130 VFEYYRGENR TQ

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939111 Genomic DNA. Translation: CAB39881.1.
PIR	T35536.
RefSeq	NP_626410.1. NC_003888.3.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	100226.SCO2154.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB39881; CAB39881; CAB39881.
GeneID	1097588.
KEGG	sco:SCO2154.
PATRIC	23733960. VBIStrCoe124346_2189.
Phylogenomic databases
eggNOG	NOG07397.
HOGENOM	HOG000237887.
OMA	YFRFVAR.
ProtClustDB	CLSK2519269.
Family and domain databases
InterPro	IPR021050. Cyt_c_oxidase_su4_actinobac. [Graphical view]
Pfam	PF12270. Cyt_c_ox_IV. 1 hit. [Graphical view]
PIRSF	PIRSF017385. CtaF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COX4_STRCO

Accession

Primary (citable) accession number: Q9X812

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program