Q9X7W3 (DXS1_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase 1
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 1
Short name=DXP synthase 1
Short name=DXPS 1

Gene names

Name:	dxs1
Synonyms:	dxs
Ordered Locus Names:	SCO6768
ORF Names:	SC6A5.17

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	656 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 656	656	1-deoxy-D-xylulose-5-phosphate synthase 1 HAMAP MF_00315		PRO_0000189157

Sequences

	Sequence		Length	Mass (Da)
	Q9X7W3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: A8E5497B50425D08	FASTA	656	69,546
	10 20 30 40 50 60 MTILENIRGP RDLKALSEAE LGELSDEIRD FLVHAVARTG GHLGPNLGVV ELTVALHRVF 70 80 90 100 110 120 ESPDDRILWD TGHQSYVHKL LTGRQDFSKL RSKGGLSGYP SREESAHDVI ENSHASTVLG 130 140 150 160 170 180 WADGLAKARQ VQGERSHVVA VIGDGALTGG MAWEALNNIA AARDRPLIIV VNDNERSYAP 190 200 210 220 230 240 TIGGLANHLA TLRTTDGYER ALAWGKDVLQ RTPVVGHTVY EALHGAKKGF KDAFAPQGLF 250 260 270 280 290 300 EDLGLKYLGP IDGHDIGAVE SALRRAKRFH GPVLVHCLTE KGRGYEPALR DEEDHFHTVG 310 320 330 340 350 360 VMDPLTCEPL GPAGGPSWTS VFGEEIVRIG EERADVVAIT AAMLHPVGLA PFAERFPDRV 370 380 390 400 410 420 WDVGIAEQHA AVSAAGLATG GLHPVVAVYA TFLNRAFDQL LMDVALHRCG VTFVLDRAGV 430 440 450 460 470 480 TGVDGASHNG MWDMSVLQVV PGLRIAAPRD ADQLRTQLRE AVAVDDAPTL LRFPKESVGP 490 500 510 520 530 540 AVPAVDRIGG LDVLHTADRS EVLLVAVGVM APVCLGAAEL LEARGIGCTV VDPRWVKPVD 550 560 570 580 590 600 PALAPLAARH RLVAVVEDNS RAAGVGSAVA LALGDAEVDV PVRRFGIPEQ FLAHAKRAEV 610 620 630 640 650 LADIGLTPVD VAGRIAASLA LAEPAGDRAG GPAVEQPGDG RMSGDGRIVM PAQGEN

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939129 Genomic DNA. Translation: CAB39701.1.
PIR	T35408.
RefSeq	NP_630840.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9X7W3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1102207.
GenomeReviews	Gene locus SCO6768 in contig AL645882_GR.
KEGG	sco:SCO6768.
NMPDR	fig|100226.1.peg.6705.
PATRIC	23743463. VBIStrCoe124346_6877.
Phylogenomic databases
HOGENOM	HBG571647.
OMA	QYDISYM.
PhylomeDB	Q9X7W3.
ProtClustDB	PRK05444.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR001017. DH_E1. IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS1_STRCO

Accession

Primary (citable) accession number: Q9X7W3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program