Q9X7U5 (IOLG_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	SCO7254
ORF Names:	SC5H1.38

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352598

Sequences

	Sequence		Length	Mass (Da)
	Q9X7U5 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 2196592F0116AEAC	FASTA	342	36,020
	10 20 30 40 50 60 MSELLGVAVL GAGHMGADHI RRVDQVVSGA RVAAVADPDA ERAKEAVGGI GGTGRITVHT 70 80 90 100 110 120 DVEAALDAPG VEAVLIASPG EAHEEALLAA FARGLPVLCE KPMAPNSAGA LRVVEAEARL 130 140 150 160 170 180 GRRLAQIGFM RRYDAEYRQL KSLLDGGRLG RPLMLHCVHR NVSSPPHFTS AMLINSSVSH 190 200 210 220 230 240 EIDAARWLLG QELSAVTVLR PRPSAGAPEG LLDPQLVLFE TEGGAVVDVE VFVNCGFGYE 250 260 270 280 290 300 VRCEAVCEAG SARIGAAHTM MVTAAGGARE EVPQDYLVRF ADAYDREVQS WVDATRRGLV 310 320 330 340 TGPGTWDGYA AAAVAEAGVR ALDTGVRTPV DMAPRPSLHD RA

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939131 Genomic DNA. Translation: CAB42963.1.
PIR	T35354.
RefSeq	NP_631310.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9X7U5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1102692.
GenomeReviews	Gene locus SCO7254 in contig AL645882_GR.
KEGG	sco:SCO7254.
NMPDR	fig|100226.1.peg.7188.
PATRIC	23744427. VBIStrCoe124346_7356.
Phylogenomic databases
HOGENOM	HBG612336.
OMA	RTEVVGE.
PhylomeDB	Q9X7U5.
ProtClustDB	CLSK636460.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_STRCO

Accession

Primary (citable) accession number: Q9X7U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program