Q9X7T2 (ADD2_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosine deaminase 2
EC=3.5.4.4

Alternative name(s):
Adenosine aminohydrolase 2

Gene names

Name:	add2
Ordered Locus Names:	SCO7268
ORF Names:	SC5H1.24c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenosine catabolic process Inferred from Biological aspect of Ancestor. Source: RefGenome hypoxanthine salvage Inferred from Biological aspect of Ancestor. Source: RefGenome inosine biosynthetic process Inferred from Biological aspect of Ancestor. Source: RefGenome purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	adenosine deaminase activity Inferred from Biological aspect of Ancestor. Source: RefGenome metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Adenosine deaminase 2 HAMAP MF_00540		PRO_0000194388
Sites
	Active site	211	1	Proton donor By similarity
	Metal binding	20	1	Zinc; catalytic By similarity
	Metal binding	22	1	Zinc; catalytic By similarity
	Metal binding	208	1	Zinc; catalytic By similarity
	Metal binding	298	1	Zinc; catalytic By similarity
	Binding site	22	1	Substrate By similarity
	Binding site	24	1	Substrate By similarity
	Binding site	181	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity
	Site	232	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9X7T2 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: F80A2C74972E1B7D	FASTA	359	38,801
	10 20 30 40 50 60 MSSTRIDTET LRRLPKAVLH DHLDGGLRPA TVVELARSVG HTLPTTDPDE LAAWYYEAAN 70 80 90 100 110 120 SGDLVRYIAT FEHTLAVMQN REGLLRAAEE YVLDLAADGV VYGEVRYAPE LNTRGGLSMR 130 140 150 160 170 180 EVVETVQEGL ATGMAKAAAA GTPVRVGTLL CGMRMFDRVR EAADLAVAFR DAGVVGFDIA 190 200 210 220 230 240 GAEDGFPPAD HLDAFEHLRR ENVPFTIHAG EAHGLPSIHQ ALQVCGAQRI GHGVRITDDI 250 260 270 280 290 300 PDLAAGKLGR LAAWVRDRRI ALEMCPTSNL QTGAATSIAE HPITALKDLG FRVTLNTDNR 310 320 330 340 350 LVSGTTMTRE MSLLVEQAGW SVEDLRTVTV NALKSAFVPF DERTALIEDV VLPAYASVL

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939131 Genomic DNA. Translation: CAB42949.1.
PIR	T35340.
RefSeq	NP_631324.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9X7T2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1102706.
GenomeReviews	Gene locus SCO7268 in contig AL645882_GR.
KEGG	sco:SCO7268.
NMPDR	fig|100226.1.peg.7202.
PATRIC	23744455. VBIStrCoe124346_7370.
Phylogenomic databases
HOGENOM	HBG630382.
OMA	ITLECCA.
PhylomeDB	Q9X7T2.
ProtClustDB	PRK09358.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD2_STRCO

Accession

Primary (citable) accession number: Q9X7T2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program